diff --git a/packages/dts-test/inject.test-d.ts b/packages/dts-test/inject.test-d.ts
index 2e8341ff0ae..ace1700bb28 100644
--- a/packages/dts-test/inject.test-d.ts
+++ b/packages/dts-test/inject.test-d.ts
@@ -12,7 +12,7 @@ import { expectType } from './utils'
 provide('foo', 123)
 provide(123, 123)
 
-const key: InjectionKey<number> = Symbol()
+const key = Symbol() as InjectionKey<number>
 
 provide(key, 1)
 // @ts-expect-error
diff --git a/packages/runtime-core/__tests__/apiInject.spec.ts b/packages/runtime-core/__tests__/apiInject.spec.ts
index e5c9267e5bb..eb9134fe4b9 100644
--- a/packages/runtime-core/__tests__/apiInject.spec.ts
+++ b/packages/runtime-core/__tests__/apiInject.spec.ts
@@ -40,7 +40,7 @@ describe('api: provide/inject', () => {
 
   it('symbol keys', () => {
     // also verifies InjectionKey type sync
-    const key: InjectionKey<number> = Symbol()
+    const key = Symbol() as InjectionKey<number>
 
     const Provider = {
       setup() {
diff --git a/packages/runtime-core/src/apiCreateApp.ts b/packages/runtime-core/src/apiCreateApp.ts
index 44bb0390c99..6dc8d64a76b 100644
--- a/packages/runtime-core/src/apiCreateApp.ts
+++ b/packages/runtime-core/src/apiCreateApp.ts
@@ -55,7 +55,7 @@ export interface App<HostElement = any> {
   ): ComponentPublicInstance
   unmount(): void
   onUnmount(cb: () => void): void
-  provide<T, K = InjectionKey<T> | string | number>(
+  provide<T, K = InjectionKey<T> | string | symbol | number>(
     key: K,
     value: K extends InjectionKey<infer V> ? V : T,
   ): this
diff --git a/packages/runtime-core/src/apiInject.ts b/packages/runtime-core/src/apiInject.ts
index f15983604bb..f824cf8e877 100644
--- a/packages/runtime-core/src/apiInject.ts
+++ b/packages/runtime-core/src/apiInject.ts
@@ -4,9 +4,10 @@ import { currentRenderingInstance } from './componentRenderContext'
 import { currentApp } from './apiCreateApp'
 import { warn } from './warning'
 
-export interface InjectionKey<T> extends Symbol {}
+declare const InjectionKeySymbol: unique symbol
+export type InjectionKey<T> = symbol & { [InjectionKeySymbol]: T }
 
-export function provide<T, K = InjectionKey<T> | string | number>(
+export function provide<T, K = InjectionKey<T> | string | number | symbol>(
   key: K,
   value: K extends InjectionKey<infer V> ? V : T,
 ) {
@@ -31,19 +32,19 @@ export function provide<T, K = InjectionKey<T> | string | number>(
   }
 }
 
-export function inject<T>(key: InjectionKey<T> | string): T | undefined
+export function inject<T>(key: InjectionKey<T> | string | symbol): T | undefined
 export function inject<T>(
-  key: InjectionKey<T> | string,
+  key: InjectionKey<T> | string | symbol,
   defaultValue: T,
   treatDefaultAsFactory?: false,
 ): T
 export function inject<T>(
-  key: InjectionKey<T> | string,
+  key: InjectionKey<T> | string | symbol,
   defaultValue: T | (() => T),
   treatDefaultAsFactory: true,
 ): T
 export function inject(
-  key: InjectionKey<any> | string,
+  key: InjectionKey<any> | string | symbol,
   defaultValue?: unknown,
   treatDefaultAsFactory = false,
 ) {