diff --git a/llvm/utils/lit/tests/lit.cfg b/llvm/utils/lit/tests/lit.cfg
index ebdcb5000b9a2..b8d6fc28060a9 100644
--- a/llvm/utils/lit/tests/lit.cfg
+++ b/llvm/utils/lit/tests/lit.cfg
@@ -37,6 +37,10 @@ else:
 
 # Required because some tests import the lit module
 llvm_config.with_environment('PYTHONPATH', lit_path, append_path=True)
+# Do not add user-site packages directory to the python search path. This avoids test failures if there's an
+# incompatible lit module installed inside the user-site packages directory, as it gets prioritized over the lit
+# from the PYTHONPATH.
+config.environment['PYTHONNOUSERSITE'] = '1'
 
 # Add llvm and lit tools directories if this config is being loaded indirectly.
 for attribute in ('llvm_tools_dir', 'lit_tools_dir'):