diff --git a/build.sbt b/build.sbt
index afd9dd9..af16efd 100644
--- a/build.sbt
+++ b/build.sbt
@@ -75,7 +75,15 @@ lazy val `scalajs-env-jsdom-nodejs`: Project = project.in(file("jsdom-nodejs-env
       "org.scala-js" %% "scalajs-env-nodejs" % scalaJSVersion,
 
       "com.novocode" % "junit-interface" % "0.11" % "test",
-      "org.scala-js" %% "scalajs-js-envs-test-kit" % scalaJSVersion % "test"
+      "org.scala-js" %% "scalajs-js-envs-test-kit" % scalaJSVersion % "test",
+
+      /* See JSDOMNodeJSEnvTest.reactUnhandledExceptionHack.
+       * We use intransitive() because we do not need the transitive
+       * dependencies of these webjars, and one of them actually fails to
+       * resolve (see https://github.com/webjars/webjars/issues/1789).
+       */
+      "org.webjars.npm" % "react" % "16.13.1" % "test" intransitive(),
+      "org.webjars.npm" % "react-dom" % "16.13.1" % "test" intransitive(),
     )
   )
 
diff --git a/jsdom-nodejs-env/src/main/scala/org/scalajs/jsenv/jsdomnodejs/JSDOMNodeJSEnv.scala b/jsdom-nodejs-env/src/main/scala/org/scalajs/jsenv/jsdomnodejs/JSDOMNodeJSEnv.scala
index 0ef7777..9193c2d 100644
--- a/jsdom-nodejs-env/src/main/scala/org/scalajs/jsenv/jsdomnodejs/JSDOMNodeJSEnv.scala
+++ b/jsdom-nodejs-env/src/main/scala/org/scalajs/jsenv/jsdomnodejs/JSDOMNodeJSEnv.scala
@@ -84,6 +84,15 @@ class JSDOMNodeJSEnv(config: JSDOMNodeJSEnv.Config) extends JSEnv {
          |  var virtualConsole = new jsdom.VirtualConsole()
          |    .sendTo(console, { omitJSDOMErrors: true });
          |  virtualConsole.on("jsdomError", function (error) {
+         |    /* #42 Counter-hack the hack that React's development mode uses
+         |     * to bypass browsers' debugging tools. If we detect that we are
+         |     * called from that hack, we do nothing.
+         |     */
+         |    var isWithinReactsInvokeGuardedCallbackDevHack_issue42 =
+         |      new Error("").stack.indexOf("invokeGuardedCallbackDev") >= 0;
+         |    if (isWithinReactsInvokeGuardedCallbackDevHack_issue42)
+         |      return;
+         |
          |    try {
          |      // Display as much info about the error as possible
          |      if (error.detail && error.detail.stack) {
diff --git a/jsdom-nodejs-env/src/test/scala/org/scalajs/jsenv/jsdomnodejs/JSDOMNodeJSEnvTest.scala b/jsdom-nodejs-env/src/test/scala/org/scalajs/jsenv/jsdomnodejs/JSDOMNodeJSEnvTest.scala
index 4199f9d..822ae1d 100644
--- a/jsdom-nodejs-env/src/test/scala/org/scalajs/jsenv/jsdomnodejs/JSDOMNodeJSEnvTest.scala
+++ b/jsdom-nodejs-env/src/test/scala/org/scalajs/jsenv/jsdomnodejs/JSDOMNodeJSEnvTest.scala
@@ -1,12 +1,20 @@
 package org.scalajs.jsenv.jsdomnodejs
 
+import java.nio.charset.StandardCharsets
+import java.nio.file.{Files, Path}
+
 import scala.concurrent.duration._
 
+import com.google.common.jimfs.Jimfs
+
 import org.junit.Test
 
+import org.scalajs.jsenv.Input
 import org.scalajs.jsenv.test.kit.TestKit
 
 class JSDOMNodeJSEnvTest {
+  import JSDOMNodeJSEnvTest._
+
   private val kit = new TestKit(new JSDOMNodeJSEnv, 1.minute)
 
   @Test
@@ -21,4 +29,98 @@ class JSDOMNodeJSEnvTest {
         .expectOut("http://localhost/foo\n")
     }
   }
+
+  @Test
+  def reactUnhandledExceptionHack_issue42: Unit = {
+    val code =
+      """
+      |const rootElement = document.createElement("div");
+      |document.body.appendChild(rootElement);
+      |
+      |class ThrowingComponent extends React.Component {
+      |  render() {
+      |    throw new Error("boom");
+      |  }
+      |}
+      |
+      |class ErrorBoundary extends React.Component {
+      |  constructor(props) {
+      |    super(props);
+      |    this.state = { hasError: false };
+      |  }
+      |
+      |  componentDidCatch(error, info) {
+      |    this.setState({error: error.message, hasError: true});
+      |  }
+      |
+      |  render() {
+      |    if (this.state.hasError) {
+      |      console.log("render-error");
+      |      return React.createElement("p", null,
+      |        `Caught error: ${this.state.error}`);
+      |    } else {
+      |      return this.props.children;
+      |    }
+      |  }
+      |}
+      |
+      |class MyMainComponent extends React.Component {
+      |  render() {
+      |    console.log("two");
+      |    return React.createElement(ErrorBoundary, null,
+      |      React.createElement(ThrowingComponent)
+      |    );
+      |  }
+      |}
+      |
+      |console.log("begin");
+      |
+      |const mounted = ReactDOM.render(
+      |  React.createElement(ErrorBoundary, null,
+      |    React.createElement(ThrowingComponent, null)
+      |  ),
+      |  rootElement
+      |);
+      |
+      |console.log(document.querySelector("p").textContent);
+      |
+      |console.log("end");
+      """.stripMargin
+
+    kit.withRun(ReactJSFiles :+ codeToInput(code)) {
+      _.expectOut("begin\nrender-error\nCaught error: boom\nend\n")
+        .succeeds()
+    }
+  }
+}
+
+object JSDOMNodeJSEnvTest {
+  private lazy val ReactJSFiles: List[Input] = {
+    val fs = Jimfs.newFileSystem()
+    val reactFile = copyResource(
+        "/META-INF/resources/webjars/react/16.13.1/umd/react.development.js",
+        fs.getPath("react.development.js"))
+    val reactDOMFile = copyResource(
+        "/META-INF/resources/webjars/react-dom/16.13.1/umd/react-dom.development.js",
+        fs.getPath("react-dom.development.js"))
+    List(reactFile, reactDOMFile).map(Input.Script(_))
+  }
+
+  private def copyResource(name: String, out: Path): out.type = {
+    val inputStream = getClass().getResourceAsStream(name)
+    assert(inputStream != null, s"couldn't load $name from resources")
+    try {
+      Files.copy(inputStream, out)
+    } finally {
+      inputStream.close()
+    }
+    out
+  }
+
+  private def codeToInput(code: String): Input = {
+    val p = Files.write(
+        Jimfs.newFileSystem().getPath("testScript.js"),
+        code.getBytes(StandardCharsets.UTF_8))
+    Input.Script(p)
+  }
 }