diff --git a/index.d.ts b/index.d.ts
index 4f6e49f..6b56beb 100644
--- a/index.d.ts
+++ b/index.d.ts
@@ -88,6 +88,7 @@ declare module 'replicate' {
         wait?: { interval?: number; max_attempts?: number };
         webhook?: string;
         webhook_events_filter?: WebhookEventType[];
+        signal?: AbortSignal;
       }
     ): Promise<object>;
 
@@ -105,7 +106,8 @@ declare module 'replicate' {
       options: {
         interval?: number;
         max_attempts?: number;
-      }
+      },
+      stop?: (Prediction) => Promise<boolean>
     ): Promise<Prediction>;
 
     collections: {
diff --git a/index.js b/index.js
index e6d50d3..b1803a1 100644
--- a/index.js
+++ b/index.js
@@ -85,6 +85,7 @@ class Replicate {
    * @param {number} [options.wait.max_attempts] - Maximum number of polling attempts. Defaults to no limit
    * @param {string} [options.webhook] - An HTTPS URL for receiving a webhook when the prediction has new output
    * @param {string[]} [options.webhook_events_filter] - You can change which events trigger webhook requests by specifying webhook events (`start`|`output`|`logs`|`completed`)
+   * @param {AbortSignal} [options.signal] - AbortSignal to cancel the prediction
    * @throws {Error} If the prediction failed
    * @returns {Promise<object>} - Resolves with the output of running the model
    */
@@ -116,7 +117,16 @@ class Replicate {
       version,
     });
 
-    prediction = await this.wait(prediction, wait || {});
+    const { signal } = options;
+
+    prediction = await this.wait(prediction, wait || {}, async ({ id }) => {
+      if (signal && signal.aborted) {
+        await this.predictions.cancel(id);
+        return true; // stop polling
+      }
+
+      return false; // continue polling
+    });
 
     if (prediction.status === 'failed') {
       throw new Error(`Prediction failed: ${prediction.error}`);
@@ -150,7 +160,11 @@ class Replicate {
       );
     }
 
-    const { method = 'GET', params = {}, data } = options;
+    const {
+      method = 'GET',
+      params = {},
+      data,
+    } = options;
 
     Object.entries(params).forEach(([key, value]) => {
       url.searchParams.append(key, value);
@@ -219,11 +233,12 @@ class Replicate {
    * @param {object} options - Options
    * @param {number} [options.interval] - Polling interval in milliseconds. Defaults to 250
    * @param {number} [options.max_attempts] - Maximum number of polling attempts. Defaults to no limit
+   * @param {Function} [stop] - Async callback function that is called after each polling attempt. Receives the prediction object as an argument. Return false to cancel polling.
    * @throws {Error} If the prediction doesn't complete within the maximum number of attempts
    * @throws {Error} If the prediction failed
    * @returns {Promise<object>} Resolves with the completed prediction object
    */
-  async wait(prediction, options) {
+  async wait(prediction, options, stop) {
     const { id } = prediction;
     if (!id) {
       throw new Error('Invalid prediction');
@@ -261,6 +276,9 @@ class Replicate {
       /* eslint-disable no-await-in-loop */
       await sleep(interval);
       updatedPrediction = await this.predictions.get(prediction.id);
+      if (stop && await stop(updatedPrediction) === true) {
+        break;
+      }
       /* eslint-enable no-await-in-loop */
     }
 
diff --git a/index.test.ts b/index.test.ts
index b726137..9147b81 100644
--- a/index.test.ts
+++ b/index.test.ts
@@ -581,6 +581,44 @@ describe('Replicate client', () => {
         });
       }).rejects.toThrow('Invalid webhook URL');
     });
+
+    test('Aborts the operation when abort signal is invoked', async () => {
+      const controller = new AbortController();
+      const { signal } = controller;
+
+      const scope = nock(BASE_URL)
+        .post('/predictions', (body) => {
+          controller.abort();
+          return body;
+        })
+        .reply(201, {
+          id: 'ufawqhfynnddngldkgtslldrkq',
+          status: 'processing',
+        })
+        .persist()
+        .get('/predictions/ufawqhfynnddngldkgtslldrkq')
+        .reply(200, {
+          id: 'ufawqhfynnddngldkgtslldrkq',
+          status: 'processing',
+        })
+        .post('/predictions/ufawqhfynnddngldkgtslldrkq/cancel')
+        .reply(200, {
+          id: 'ufawqhfynnddngldkgtslldrkq',
+          status: 'canceled',
+        });;
+
+      await client.run(
+        'owner/model:5c7d5dc6dd8bf75c1acaa8565735e7986bc5b66206b55cca93cb72c9bf15ccaa',
+        {
+          input: { text: 'Hello, world!' },
+          signal,
+        }
+      )
+
+      expect(signal.aborted).toBe(true);
+
+      scope.done();
+    });
   });
 
   // Continue with tests for other methods