diff --git a/mypy/plugins/functools.py b/mypy/plugins/functools.py
index 81a3b4d96ef3..3faa1398abd9 100644
--- a/mypy/plugins/functools.py
+++ b/mypy/plugins/functools.py
@@ -7,6 +7,7 @@
 import mypy.checker
 import mypy.plugin
 from mypy.argmap import map_actuals_to_formals
+from mypy.expandtype import expand_type
 from mypy.nodes import ARG_POS, ARG_STAR2, ArgKind, Argument, FuncItem, Var
 from mypy.plugins.common import add_method_to_class
 from mypy.types import (
@@ -124,11 +125,12 @@ def partial_new_callback(ctx: mypy.plugin.FunctionContext) -> Type:
         return ctx.default_return_type
     if len(ctx.arg_types[0]) != 1:
         return ctx.default_return_type
+    fn = expand_type(get_proper_type(ctx.arg_types[0][0]), {})
 
-    if isinstance(get_proper_type(ctx.arg_types[0][0]), Overloaded):
+    if isinstance(fn, Overloaded):
         # TODO: handle overloads, just fall back to whatever the non-plugin code does
         return ctx.default_return_type
-    fn_type = ctx.api.extract_callable_type(ctx.arg_types[0][0], ctx=ctx.default_return_type)
+    fn_type = ctx.api.extract_callable_type(fn, ctx=ctx.default_return_type)
     if fn_type is None:
         return ctx.default_return_type
 
diff --git a/test-data/unit/check-functools.test b/test-data/unit/check-functools.test
index 5af5dfc8e469..67d11f5fce73 100644
--- a/test-data/unit/check-functools.test
+++ b/test-data/unit/check-functools.test
@@ -324,3 +324,13 @@ p(bar, 1, "a", 3.0)  # OK
 p(bar, 1, "a", 3.0, kwarg="asdf")  # OK
 p(bar, 1, "a", "b")  # E: Argument 1 to "foo" has incompatible type "Callable[[int, str, float], None]"; expected "Callable[[int, str, str], None]"
 [builtins fixtures/dict.pyi]
+
+[case testFunctoolsPartialUnion]
+import functools
+from typing import Any, Union
+
+cls1: Any
+cls2: Union[Any, Any]
+functools.partial(cls1, 2)
+functools.partial(cls2, 2)
+[builtins fixtures/tuple.pyi]