diff --git a/mypy/fastparse.py b/mypy/fastparse.py
index 2f4122bf3bfa..386bfb94800c 100644
--- a/mypy/fastparse.py
+++ b/mypy/fastparse.py
@@ -130,6 +130,8 @@ def ast3_parse(source: Union[str, bytes], filename: str, mode: str,
 
 INVALID_TYPE_IGNORE: Final = 'Invalid "type: ignore" comment'
 
+INVALID_SLICE_ERROR: Final = 'Slice usage in type annotation is invalid'
+
 TYPE_IGNORE_PATTERN = re.compile(r'[^#]*#\s*type:\s*ignore\s*(.*)')
 
 
@@ -1560,12 +1562,12 @@ def visit_Subscript(self, n: ast3.Subscript) -> Type:
             if (isinstance(sliceval, ast3.Slice) or
                 (isinstance(sliceval, ast3.Tuple) and
                  any(isinstance(x, ast3.Slice) for x in sliceval.elts))):
-                self.fail(TYPE_COMMENT_SYNTAX_ERROR, self.line, getattr(n, 'col_offset', -1))
+                self.fail(INVALID_SLICE_ERROR, self.line, getattr(n, 'col_offset', -1))
                 return AnyType(TypeOfAny.from_error)
         else:
             # Python 3.8 or earlier use a different AST structure for subscripts
             if not isinstance(n.slice, Index):
-                self.fail(TYPE_COMMENT_SYNTAX_ERROR, self.line, getattr(n, 'col_offset', -1))
+                self.fail(INVALID_SLICE_ERROR, self.line, getattr(n, 'col_offset', -1))
                 return AnyType(TypeOfAny.from_error)
             sliceval = n.slice.value
 
diff --git a/test-data/unit/check-fastparse.test b/test-data/unit/check-fastparse.test
index 497ed9b1d2b2..03aa1e4c3214 100644
--- a/test-data/unit/check-fastparse.test
+++ b/test-data/unit/check-fastparse.test
@@ -322,7 +322,7 @@ x @= 1
 from typing import Dict
 x = None # type: Dict[x: y]
 [out]
-main:3: error: syntax error in type comment
+main:3: error: Slice usage in type annotation is invalid
 
 [case testPrintStatementTrailingCommaFastParser_python2]
 
diff --git a/test-data/unit/parse.test b/test-data/unit/parse.test
index 22b1ab28481d..f9bbb7dda5a4 100644
--- a/test-data/unit/parse.test
+++ b/test-data/unit/parse.test
@@ -949,6 +949,88 @@ main:1: error: invalid syntax
 [out version>=3.10]
 main:1: error: invalid syntax. Perhaps you forgot a comma?
 
+[case testSliceInAnnotation39]
+# flags: --python-version 3.9
+a: Annotated[int, 1:2]  # E: Slice usage in type annotation is invalid
+b: Dict[int, x:y]  # E: Slice usage in type annotation is invalid
+c: Dict[x:y]  # E: Slice usage in type annotation is invalid
+[out]
+
+[case testSliceInAnnotation38]
+# flags: --python-version 3.8
+a: Annotated[int, 1:2]  # E: Slice usage in type annotation is invalid
+b: Dict[int, x:y]  # E: Slice usage in type annotation is invalid
+c: Dict[x:y]  # E: Slice usage in type annotation is invalid
+[out]
+
+[case testSliceInAnnotationTypeComment39]
+# flags: --python-version 3.9
+a = None  # type: Annotated[int, 1:2]  # E: Slice usage in type annotation is invalid
+b = None  # type: Dict[int, x:y]  # E: Slice usage in type annotation is invalid
+c = None  # type: Dict[x:y]  # E: Slice usage in type annotation is invalid
+[out]
+
+[case testCorrectSlicesInAnnotations39]
+# flags: --python-version 3.9
+a: Annotated[int, slice(1, 2)]
+b: Dict[int, {x:y}]
+c: Dict[{x:y}]
+[out]
+MypyFile:1(
+  AssignmentStmt:2(
+    NameExpr(a)
+    TempNode:2(
+      Any)
+    Annotated?[int?, None])
+  AssignmentStmt:3(
+    NameExpr(b)
+    TempNode:3(
+      Any)
+    Dict?[int?, None])
+  AssignmentStmt:4(
+    NameExpr(c)
+    TempNode:4(
+      Any)
+    Dict?[None]))
+
+[case testCorrectSlicesInAnnotations38]
+# flags: --python-version 3.8
+a: Annotated[int, slice(1, 2)]
+b: Dict[int, {x:y}]
+c: Dict[{x:y}]
+[out]
+MypyFile:1(
+  AssignmentStmt:2(
+    NameExpr(a)
+    TempNode:2(
+      Any)
+    Annotated?[int?, None])
+  AssignmentStmt:3(
+    NameExpr(b)
+    TempNode:3(
+      Any)
+    Dict?[int?, None])
+  AssignmentStmt:4(
+    NameExpr(c)
+    TempNode:4(
+      Any)
+    Dict?[None]))
+
+[case testSliceInList39]
+# flags: --python-version 3.9
+x = [1, 2][1:2]
+[out]
+MypyFile:1(
+  AssignmentStmt:2(
+    NameExpr(x)
+    IndexExpr:2(
+      ListExpr:2(
+        IntExpr(1)
+        IntExpr(2))
+      SliceExpr:2(
+        IntExpr(1)
+        IntExpr(2)))))
+
 [case testDictionaryExpression]
 {}
 {1:x}