diff --git a/Lib/test/test_py_compile.py b/Lib/test/test_py_compile.py
index 794d6436b61ab0..437ba113f482be 100644
--- a/Lib/test/test_py_compile.py
+++ b/Lib/test/test_py_compile.py
@@ -235,11 +235,12 @@ def pycompilecmd(self, *args, **kwargs):
         # assert_python_* helpers don't return proc object. We'll just use
         # subprocess.run() instead of spawn_python() and its friends to test
         # stdin support of the CLI.
+        opts = '-m' if __debug__ else '-Om'
         if args and args[0] == '-' and 'input' in kwargs:
-            return subprocess.run([sys.executable, '-m', 'py_compile', '-'],
+            return subprocess.run([sys.executable, opts, 'py_compile', '-'],
                                   input=kwargs['input'].encode(),
                                   capture_output=True)
-        return script_helper.assert_python_ok('-m', 'py_compile', *args, **kwargs)
+        return script_helper.assert_python_ok(opts, 'py_compile', *args, **kwargs)
 
     def pycompilecmd_failure(self, *args):
         return script_helper.assert_python_failure('-m', 'py_compile', *args)
diff --git a/Misc/NEWS.d/next/Tests/2022-05-25-22-53-30.gh-issue-92886.mIfdtz.rst b/Misc/NEWS.d/next/Tests/2022-05-25-22-53-30.gh-issue-92886.mIfdtz.rst
new file mode 100644
index 00000000000000..014e9e614ccabc
--- /dev/null
+++ b/Misc/NEWS.d/next/Tests/2022-05-25-22-53-30.gh-issue-92886.mIfdtz.rst
@@ -0,0 +1 @@
+Fixing tests that fail when running with optimizations (``-O``) in ``test_py_compile.py``