diff --git a/Lib/test/test_typing.py b/Lib/test/test_typing.py
index 88be2850acb1cc..7f36a421a58595 100644
--- a/Lib/test/test_typing.py
+++ b/Lib/test/test_typing.py
@@ -5811,6 +5811,8 @@ def test_typeddict_errors(self):
             isinstance(jim, Emp)
         with self.assertRaises(TypeError):
             issubclass(dict, Emp)
+        with self.assertRaises(TypeError):
+            Emp[int, str]
         with self.assertRaises(TypeError):
             TypedDict('Hi', [('x', int)], y=int)
 
diff --git a/Lib/typing.py b/Lib/typing.py
index 35deb32220eb88..c9c190f4a1b4ff 100644
--- a/Lib/typing.py
+++ b/Lib/typing.py
@@ -2883,6 +2883,7 @@ def __new__(cls, name, bases, ns, total=True):
         tp_dict.__optional_keys__ = frozenset(optional_keys)
         if not hasattr(tp_dict, '__total__'):
             tp_dict.__total__ = total
+        tp_dict.__class_getitem__ = None
         return tp_dict
 
     __call__ = dict  # static method
diff --git a/Misc/NEWS.d/next/Library/2022-05-01-16-58-31.gh-issue-92106.qjt1Gq.rst b/Misc/NEWS.d/next/Library/2022-05-01-16-58-31.gh-issue-92106.qjt1Gq.rst
new file mode 100644
index 00000000000000..941ebeb84adb69
--- /dev/null
+++ b/Misc/NEWS.d/next/Library/2022-05-01-16-58-31.gh-issue-92106.qjt1Gq.rst
@@ -0,0 +1,2 @@
+:class:`typing.TypedDict` types are non-generic by default. Subscripting
+them raises now TypeError.