diff --git a/Lib/test/test_uuid.py b/Lib/test/test_uuid.py
index f21bd6dfa15235..2d22de87655618 100644
--- a/Lib/test/test_uuid.py
+++ b/Lib/test/test_uuid.py
@@ -305,7 +305,7 @@ def test_exceptions(self):
 
     def test_getnode(self):
         node1 = self.uuid.getnode()
-        self.assertTrue(0 < node1 < (1 << 48), '%012x' % node1)
+        self.check_node(node1)
 
         # Test it again to ensure consistency.
         node2 = self.uuid.getnode()
@@ -518,7 +518,11 @@ def check_node(self, node, requires=None):
         hex = '%012x' % node
         if support.verbose >= 2:
             print(hex, end=' ')
-        self.assertTrue(0 < node < (1 << 48),
+        if network:
+            # 47 bit will never be set in IEEE 802 addresses obtained
+            # from network cards.
+            self.assertFalse(node & 0x010000000000, hex)
+        self.assertTrue(0 <= node < (1 << 48),
                         "%s is not an RFC 4122 node ID" % hex)
 
     @unittest.skipUnless(os.name == 'posix', 'requires Posix')
@@ -582,7 +586,7 @@ def test_unix_getnode(self):
     @unittest.skipUnless(importable('ctypes'), 'requires ctypes')
     def test_windll_getnode(self):
         node = self.uuid._windll_getnode()
-        self.check_node(node)
+        self.check_node(node, network=True)
 
 
 class TestInternalsWithoutExtModule(BaseTestInternals, unittest.TestCase):