diff --git a/Lib/inspect.py b/Lib/inspect.py
index 89b2e722be8fad..e532913ea5d6c9 100644
--- a/Lib/inspect.py
+++ b/Lib/inspect.py
@@ -781,6 +781,8 @@ def getfile(object):
             module = sys.modules.get(object.__module__)
             if getattr(module, '__file__', None):
                 return module.__file__
+            if object.__module__ == '__main__':
+                raise OSError('source code not available')
         raise TypeError('{!r} is a built-in class'.format(object))
     if ismethod(object):
         object = object.__func__
diff --git a/Lib/test/test_inspect.py b/Lib/test/test_inspect.py
index 69f17f2477a2f2..c1252c32ab2504 100644
--- a/Lib/test/test_inspect.py
+++ b/Lib/test/test_inspect.py
@@ -585,6 +585,20 @@ def monkey(filename, module_globals=None):
     def test_getsource_on_code_object(self):
         self.assertSourceEqual(mod.eggs.__code__, 12, 18)
 
+class TestGetsourceInteractive(unittest.TestCase):
+    def tearDown(self):
+        mod.ParrotDroppings.__module__ = mod
+        sys.modules['__main__'] = self.main
+
+    def test_getclasses_interactive(self):
+        self.main = sys.modules['__main__']
+        class MockModule:
+            __file__ = None
+        sys.modules['__main__'] = MockModule
+        mod.ParrotDroppings.__module__ = '__main__'
+        with self.assertRaisesRegex(OSError, 'source code not available') as e:
+            inspect.getsource(mod.ParrotDroppings)
+
 class TestGettingSourceOfToplevelFrames(GetSourceBase):
     fodderModule = mod
 
@@ -4301,7 +4315,8 @@ def test_main():
         TestBoundArguments, TestSignaturePrivateHelpers,
         TestSignatureDefinitions, TestIsDataDescriptor,
         TestGetClosureVars, TestUnwrap, TestMain, TestReload,
-        TestGetCoroutineState, TestGettingSourceOfToplevelFrames
+        TestGetCoroutineState, TestGettingSourceOfToplevelFrames,
+        TestGetsourceInteractive,
     )
 
 if __name__ == "__main__":
diff --git a/Misc/NEWS.d/next/Library/2021-07-15-16-51-32.bpo-44648.2o49TB.rst b/Misc/NEWS.d/next/Library/2021-07-15-16-51-32.bpo-44648.2o49TB.rst
new file mode 100644
index 00000000000000..f7171c3c84c5ea
--- /dev/null
+++ b/Misc/NEWS.d/next/Library/2021-07-15-16-51-32.bpo-44648.2o49TB.rst
@@ -0,0 +1,3 @@
+Fixed wrong error being thrown by :func:`inspect.getsource` when examining a
+class in the interactive session. Instead of :exc:`TypeError`, it should be
+:exc:`OSError` with appropriate error message.