diff --git a/Lib/functools.py b/Lib/functools.py
index b1f1fe8d9a6f27..ccc9fad1f56fa8 100644
--- a/Lib/functools.py
+++ b/Lib/functools.py
@@ -476,6 +476,8 @@ def _make_key(args, kwds, typed,
         return key[0]
     return _HashedSeq(key)
 
+_LRU_CACHE_WRAPPER_ASSIGNMENTS = frozenset(WRAPPER_ASSIGNMENTS).union(
+        ('__defaults__', '__kwdefaults__'))
 def lru_cache(maxsize=128, typed=False):
     """Least-recently-used cache decorator.
 
@@ -510,7 +512,7 @@ def lru_cache(maxsize=128, typed=False):
         user_function, maxsize = maxsize, 128
         wrapper = _lru_cache_wrapper(user_function, maxsize, typed, _CacheInfo)
         wrapper.cache_parameters = lambda : {'maxsize': maxsize, 'typed': typed}
-        return update_wrapper(wrapper, user_function)
+        return update_wrapper(wrapper, user_function, assigned=_LRU_CACHE_WRAPPER_ASSIGNMENTS)
     elif maxsize is not None:
         raise TypeError(
             'Expected first argument to be an integer, a callable, or None')
@@ -518,7 +520,7 @@ def lru_cache(maxsize=128, typed=False):
     def decorating_function(user_function):
         wrapper = _lru_cache_wrapper(user_function, maxsize, typed, _CacheInfo)
         wrapper.cache_parameters = lambda : {'maxsize': maxsize, 'typed': typed}
-        return update_wrapper(wrapper, user_function)
+        return update_wrapper(wrapper, user_function, assigned=_LRU_CACHE_WRAPPER_ASSIGNMENTS)
 
     return decorating_function
 
diff --git a/Lib/test/test_functools.py b/Lib/test/test_functools.py
index 3320ab7ec6649d..a6104547325c4d 100644
--- a/Lib/test/test_functools.py
+++ b/Lib/test/test_functools.py
@@ -1728,6 +1728,18 @@ def test_staticmethod(x):
         for ref in refs:
             self.assertIsNone(ref())
 
+    def test_lru_defaults_bug44003(self):
+        @self.module.lru_cache(maxsize=None)
+        def func(arg='ARG', *, kw: str = 'KW'):
+            return arg, kw
+
+        self.assertEqual(func.__wrapped__.__annotations__, {'kw': str})
+        self.assertEqual(func.__wrapped__.__defaults__, ('ARG',))
+        self.assertEqual(func.__wrapped__.__kwdefaults__, {'kw': 'KW'})
+        self.assertEqual(func.__annotations__, {'kw': str})
+        self.assertEqual(func.__defaults__, ('ARG',))
+        self.assertEqual(func.__kwdefaults__, {'kw': 'KW'})
+
 
 @py_functools.lru_cache()
 def py_cached_func(x, y):
diff --git a/Modules/_functoolsmodule.c b/Modules/_functoolsmodule.c
index 19cfa9b07b340d..0aa2cf0be28a5c 100644
--- a/Modules/_functoolsmodule.c
+++ b/Modules/_functoolsmodule.c
@@ -19,6 +19,7 @@ typedef struct _functools_state {
     PyTypeObject *partial_type;
     PyTypeObject *keyobject_type;
     PyTypeObject *lru_list_elem_type;
+    PyObject *lru_obj_attrs_to_clone;
 } _functools_state;
 
 static inline _functools_state *
@@ -1138,7 +1139,8 @@ bounded_lru_cache_wrapper(lru_cache_object *self, PyObject *args, PyObject *kwds
 static PyObject *
 lru_cache_new(PyTypeObject *type, PyObject *args, PyObject *kw)
 {
-    PyObject *func, *maxsize_O, *cache_info_type, *cachedict;
+    PyObject *func, *maxsize_O, *cache_info_type, *cachedict, *obj_dict;
+    PyObject *defaults_str;
     int typed;
     lru_cache_object *obj;
     Py_ssize_t maxsize;
@@ -1188,9 +1190,41 @@ lru_cache_new(PyTypeObject *type, PyObject *args, PyObject *kw)
     if (!(cachedict = PyDict_New()))
         return NULL;
 
+    obj_dict = PyDict_New();
+    if (obj_dict == NULL) {
+        Py_DECREF(cachedict);
+        return NULL;
+    }
+
+    /* Copy special attributes from the original function over to ours. */
+    for (Py_ssize_t idx = 0;
+         idx < PyTuple_GET_SIZE(state->lru_obj_attrs_to_clone);
+         ++idx) {
+        PyObject *attr_name = PyTuple_GET_ITEM(state->lru_obj_attrs_to_clone, idx);
+        if (attr_name == NULL) {
+            Py_DECREF(cachedict);
+            Py_DECREF(obj_dict);
+            return NULL;
+        }
+        PyObject *attr = PyObject_GetAttr(func, attr_name);
+        if (attr != NULL) {
+            if (PyDict_SetItem(obj_dict, attr_name, attr) != 0) {
+                Py_DECREF(attr);
+                Py_DECREF(cachedict);
+                Py_DECREF(obj_dict);
+                return NULL;
+            }
+            Py_DECREF(attr);
+        } else {
+            /* The wrapped object didn't have attribute attr_name. */
+            PyErr_Clear();
+        }
+    }
+
     obj = (lru_cache_object *)type->tp_alloc(type, 0);
     if (obj == NULL) {
         Py_DECREF(cachedict);
+        Py_DECREF(obj_dict);
         return NULL;
     }
 
@@ -1209,7 +1243,7 @@ lru_cache_new(PyTypeObject *type, PyObject *args, PyObject *kw)
     obj->lru_list_elem_type = state->lru_list_elem_type;
     Py_INCREF(cache_info_type);
     obj->cache_info_type = cache_info_type;
-    obj->dict = NULL;
+    obj->dict = obj_dict;
     obj->weakreflist = NULL;
     return (PyObject *)obj;
 }
@@ -1421,6 +1455,23 @@ static int
 _functools_exec(PyObject *module)
 {
     _functools_state *state = get_functools_state(module);
+    state->lru_obj_attrs_to_clone = PyTuple_New(2);
+    if (state->lru_obj_attrs_to_clone == NULL) {
+        return -1;
+    }
+    {
+        PyObject *tmp;
+        PyObject *lru_attrs = state->lru_obj_attrs_to_clone;
+        tmp = PyUnicode_InternFromString("__defaults__");
+        if (tmp == NULL || PyTuple_SetItem(lru_attrs, 0, tmp) != 0) {  // steal
+            return -1;
+        }
+        tmp = PyUnicode_InternFromString("__kwdefaults__");
+        if (tmp == NULL || PyTuple_SetItem(lru_attrs, 1, tmp) != 0) {  // steal
+            return -1;
+        }
+    }
+
     state->kwd_mark = _PyObject_CallNoArg((PyObject *)&PyBaseObject_Type);
     if (state->kwd_mark == NULL) {
         return -1;
@@ -1475,6 +1526,7 @@ _functools_traverse(PyObject *module, visitproc visit, void *arg)
     Py_VISIT(state->partial_type);
     Py_VISIT(state->keyobject_type);
     Py_VISIT(state->lru_list_elem_type);
+    Py_VISIT(state->lru_obj_attrs_to_clone);
     return 0;
 }
 
@@ -1486,6 +1538,7 @@ _functools_clear(PyObject *module)
     Py_CLEAR(state->partial_type);
     Py_CLEAR(state->keyobject_type);
     Py_CLEAR(state->lru_list_elem_type);
+    Py_CLEAR(state->lru_obj_attrs_to_clone);
     return 0;
 }