diff --git a/Misc/NEWS.d/next/Core and Builtins/2019-09-28-22-54-25.bpo-38310.YDTbEo.rst b/Misc/NEWS.d/next/Core and Builtins/2019-09-28-22-54-25.bpo-38310.YDTbEo.rst
new file mode 100644
index 00000000000000..5c3086b607d034
--- /dev/null
+++ b/Misc/NEWS.d/next/Core and Builtins/2019-09-28-22-54-25.bpo-38310.YDTbEo.rst	
@@ -0,0 +1 @@
+Predict ``BUILD_MAP_UNPACK_WITH_CALL`` -> ``CALL_FUNCTION_EX`` opcode pairs in the main interpreter loop. Patch by Brandt Bucher.
\ No newline at end of file
diff --git a/Python/ceval.c b/Python/ceval.c
index f9e03b3097f0b7..3e1907e878f254 100644
--- a/Python/ceval.c
+++ b/Python/ceval.c
@@ -2943,6 +2943,7 @@ _PyEval_EvalFrameDefault(PyFrameObject *f, int throwflag)
             while (oparg--)
                 Py_DECREF(POP());
             PUSH(sum);
+            PREDICT(CALL_FUNCTION_EX);
             DISPATCH();
         }
 
@@ -3522,6 +3523,7 @@ _PyEval_EvalFrameDefault(PyFrameObject *f, int throwflag)
         }
 
         case TARGET(CALL_FUNCTION_EX): {
+            PREDICTED(CALL_FUNCTION_EX);
             PyObject *func, *callargs, *kwargs = NULL, *result;
             if (oparg & 0x01) {
                 kwargs = POP();