diff --git a/Misc/NEWS.d/next/Core_and_Builtins/2025-04-16-12-02-26.gh-issue-129210.a5uLpE.rst b/Misc/NEWS.d/next/Core_and_Builtins/2025-04-16-12-02-26.gh-issue-129210.a5uLpE.rst
new file mode 100644
index 00000000000000..85041c26c1b0e7
--- /dev/null
+++ b/Misc/NEWS.d/next/Core_and_Builtins/2025-04-16-12-02-26.gh-issue-129210.a5uLpE.rst
@@ -0,0 +1,2 @@
+Optimise garbage collection in case where no objects to collect have
+finalizers, and hence cannot be resurrected.
diff --git a/Python/gc.c b/Python/gc.c
index dad088e09f872f..198f881fac50dc 100644
--- a/Python/gc.c
+++ b/Python/gc.c
@@ -1073,12 +1073,14 @@ handle_legacy_finalizers(PyThreadState *tstate,
 /* Run first-time finalizers (if any) on all the objects in collectable.
  * Note that this may remove some (or even all) of the objects from the
  * list, due to refcounts falling to 0.
+ * Return 1 if any finalizers were run.
  */
-static void
+static int
 finalize_garbage(PyThreadState *tstate, PyGC_Head *collectable)
 {
     destructor finalize;
     PyGC_Head seen;
+    int finalizer_run = 0;
 
     /* While we're going through the loop, `finalize(op)` may cause op, or
      * other objects, to be reclaimed via refcounts falling to zero.  So
@@ -1097,6 +1099,7 @@ finalize_garbage(PyThreadState *tstate, PyGC_Head *collectable)
         if (!_PyGC_FINALIZED(op) &&
             (finalize = Py_TYPE(op)->tp_finalize) != NULL)
         {
+            finalizer_run = 1;
             _PyGC_SET_FINALIZED(op);
             Py_INCREF(op);
             finalize(op);
@@ -1105,6 +1108,7 @@ finalize_garbage(PyThreadState *tstate, PyGC_Head *collectable)
         }
     }
     gc_list_merge(&seen, collectable);
+    return finalizer_run;
 }
 
 /* Break reference cycles by clearing the containers involved.  This is
@@ -1736,20 +1740,29 @@ gc_collect_region(PyThreadState *tstate,
     validate_list(&unreachable, collecting_set_unreachable_clear);
 
     /* Call tp_finalize on objects which have one. */
-    finalize_garbage(tstate, &unreachable);
-    /* Handle any objects that may have resurrected after the call
-     * to 'finalize_garbage' and continue the collection with the
-     * objects that are still unreachable */
+    int check_resurrected = finalize_garbage(tstate, &unreachable);
+
+    /* If no finalizers have run, no objects can have been resurrected: in that
+     * case skip the resurrection check and just use the existing unreachable
+     * list. Otherwise we need to check and handle any objects that may have
+     * resurrected after the call to 'finalize_garbage' and continue the
+     * collection with the objects that are still unreachable. */
     PyGC_Head final_unreachable;
-    gc_list_init(&final_unreachable);
-    handle_resurrected_objects(&unreachable, &final_unreachable, to);
+    PyGC_Head *to_delete;
+    if (check_resurrected) {
+        gc_list_init(&final_unreachable);
+        handle_resurrected_objects(&unreachable, &final_unreachable, to);
+        to_delete = &final_unreachable;
+    } else {
+        to_delete = &unreachable;
+    }
 
     /* Call tp_clear on objects in the final_unreachable set.  This will cause
     * the reference cycles to be broken.  It may also cause some objects
     * in finalizers to be freed.
     */
-    stats->collected += gc_list_size(&final_unreachable);
-    delete_garbage(tstate, gcstate, &final_unreachable, to);
+    stats->collected += gc_list_size(to_delete);
+    delete_garbage(tstate, gcstate, to_delete, to);
 
     /* Collect statistics on uncollectable objects found and print
      * debugging information. */
diff --git a/Python/gc_free_threading.c b/Python/gc_free_threading.c
index fa4cb56f01e800..e9a766fa338de9 100644
--- a/Python/gc_free_threading.c
+++ b/Python/gc_free_threading.c
@@ -1592,12 +1592,14 @@ debug_cycle(const char *msg, PyObject *op)
 /* Run first-time finalizers (if any) on all the objects in collectable.
  * Note that this may remove some (or even all) of the objects from the
  * list, due to refcounts falling to 0.
+ * Return 1 if any finalizers were run.
  */
-static void
+static int
 finalize_garbage(struct collection_state *state)
 {
     // NOTE: the unreachable worklist holds a strong reference to the object
     // to prevent it from being deallocated while we are holding on to it.
+    int finalizer_run = 0;
     PyObject *op;
     WORKSTACK_FOR_EACH(&state->unreachable, op) {
         if (!_PyGC_FINALIZED(op)) {
@@ -1605,10 +1607,12 @@ finalize_garbage(struct collection_state *state)
             if (finalize != NULL) {
                 _PyGC_SET_FINALIZED(op);
                 finalize(op);
+                finalizer_run = 1;
                 assert(!_PyErr_Occurred(_PyThreadState_GET()));
             }
         }
     }
+    return finalizer_run;
 }
 
 // Break reference cycles by clearing the containers involved.
@@ -2009,11 +2013,13 @@ gc_collect_internal(PyInterpreterState *interp, struct collection_state *state,
     // Call weakref callbacks and finalizers after unpausing other threads to
     // avoid potential deadlocks.
     call_weakref_callbacks(state);
-    finalize_garbage(state);
+    int check_resurrected = finalize_garbage(state);
 
-    // Handle any objects that may have resurrected after the finalization.
     _PyEval_StopTheWorld(interp);
-    err = handle_resurrected_objects(state);
+    // Handle any objects that may have resurrected after finalization, if any
+    if (check_resurrected) {
+        err = handle_resurrected_objects(state);
+    }
     // Clear free lists in all threads
     _PyGC_ClearAllFreeLists(interp);
     _PyEval_StartTheWorld(interp);