diff --git a/Lib/test/test_os.py b/Lib/test/test_os.py
index 6e40cb4f58bfee..0353c2b4866c45 100644
--- a/Lib/test/test_os.py
+++ b/Lib/test/test_os.py
@@ -4349,6 +4349,9 @@ def test_timerfd_non_blocking(self):
         # confirm if timerfd is readable and read() returns 1 as bytes.
         self.assertEqual(self.read_count_signaled(fd), 1)
 
+    @unittest.skipIf(sys.platform.startswith('netbsd'),
+                     "gh-131263: Skip on NetBSD due to system freeze "
+                     "with negative timer values")
     def test_timerfd_negative(self):
         one_sec_in_nsec = 10**9
         fd = self.timerfd_create(time.CLOCK_REALTIME)