diff --git a/Lib/test/test_genericalias.py b/Lib/test/test_genericalias.py
index 5c13897b8d9d4f..af4249150df798 100644
--- a/Lib/test/test_genericalias.py
+++ b/Lib/test/test_genericalias.py
@@ -101,6 +101,7 @@
 class BaseTest(unittest.TestCase):
     """Test basics."""
     generic_types = [type, tuple, list, dict, set, frozenset, enumerate, memoryview,
+                     slice,
                      defaultdict, deque,
                      SequenceMatcher,
                      dircmp,
diff --git a/Misc/NEWS.d/next/Core_and_Builtins/2024-12-29-21-33-08.gh-issue-128334.3c5Nou.rst b/Misc/NEWS.d/next/Core_and_Builtins/2024-12-29-21-33-08.gh-issue-128334.3c5Nou.rst
new file mode 100644
index 00000000000000..2908db863e076f
--- /dev/null
+++ b/Misc/NEWS.d/next/Core_and_Builtins/2024-12-29-21-33-08.gh-issue-128334.3c5Nou.rst
@@ -0,0 +1 @@
+Make the :class:`slice` class subscriptable at runtime to be consistent with typing implementation.
diff --git a/Objects/sliceobject.c b/Objects/sliceobject.c
index 5186ff4f6f0cf5..2a402bb3347d60 100644
--- a/Objects/sliceobject.c
+++ b/Objects/sliceobject.c
@@ -569,6 +569,7 @@ PyDoc_STRVAR(reduce_doc, "Return state information for pickling.");
 static PyMethodDef slice_methods[] = {
     {"indices", slice_indices, METH_O, slice_indices_doc},
     {"__reduce__", slice_reduce, METH_NOARGS, reduce_doc},
+    {"__class_getitem__", Py_GenericAlias, METH_O|METH_CLASS, "See PEP 585"},
     {NULL, NULL}
 };