diff --git a/.github/workflows/main.yml b/.github/workflows/main.yml
index 2aa60df..b2cbf70 100644
--- a/.github/workflows/main.yml
+++ b/.github/workflows/main.yml
@@ -5,9 +5,6 @@ concurrency:
   group: ${{ github.head_ref || github.run_id }}
   cancel-in-progress: true
 
-env:
-  CONDA_EXE: mamba
-
 on:
   push:
     branches:
@@ -25,13 +22,10 @@ jobs:
 
     steps:
       - uses: actions/checkout@v4
-      - uses: actions/setup-python@v5
+      - uses: astral-sh/setup-uv@v5
         with:
-          python-version-file: .python-version
-          allow-prereleases: true
-          cache: pip
-      - run: pip install tox-uv
-      - run: tox -e typing
+          enable-cache: true
+      - run: uv run --extra typing mypy
 
   run-tests:
 
@@ -48,18 +42,16 @@ jobs:
       - uses: actions/checkout@v4
       - uses: r-lib/actions/setup-tinytex@v2
         if: runner.os != 'Windows'
-      - uses: actions/setup-python@v5
+      - uses: astral-sh/setup-uv@v5
         with:
+          enable-cache: true
           python-version: ${{ matrix.python-version }}
-          cache: pip
-          allow-prereleases: true
-      - run: pip install tox
 
       # Unit, integration, and end-to-end tests.
 
       - name: Run unit tests and doctests.
         shell: bash -l {0}
-        run: tox -e pytest -- -m "unit or (not integration and not end_to_end)" --cov=./ --cov-report=xml -n auto
+        run: uv run --extra test pytest -m "unit or (not integration and not end_to_end)" --cov=./ --cov-report=xml -n auto
 
       - name: Upload coverage report for unit tests and doctests.
         if: runner.os == 'Linux' && matrix.python-version == '3.10'
@@ -68,7 +60,7 @@ jobs:
 
       - name: Run end-to-end tests.
         shell: bash -l {0}
-        run: tox -e pytest -- -m end_to_end --cov=./ --cov-report=xml -n auto
+        run: uv run --extra test pytest -m end_to_end --cov=./ --cov-report=xml -n auto
 
       - name: Upload coverage reports of end-to-end tests.
         if: runner.os == 'Linux' && matrix.python-version == '3.10'
diff --git a/CHANGES.md b/CHANGES.md
index b7766da..26f2a36 100644
--- a/CHANGES.md
+++ b/CHANGES.md
@@ -4,10 +4,11 @@ This is a record of all past pytask-latex releases and what went into them in re
 chronological order. Releases follow [semantic versioning](https://semver.org/) and all
 releases are available on [Anaconda.org](https://anaconda.org/conda-forge/pytask-latex).
 
-## 0.4.3 - 2025-06-xx
+## 0.4.3 - 2025-06-01
 
 - {pull}`75` adds rye.
 - {pull}`81` adds support for Python 3.13 and drops support for Python 3.8.
+- {pull}`82` remove setup with tox-uv.
 
 ## 0.4.2 - 2023-11-30
 
diff --git a/tox.ini b/tox.ini
deleted file mode 100644
index 11b16f3..0000000
--- a/tox.ini
+++ /dev/null
@@ -1,15 +0,0 @@
-[tox]
-envlist = pytest
-
-[testenv]
-usedevelop = true
-passenv = CI
-
-[testenv:pytest]
-extras = test
-commands =
-    pytest {posargs}
-
-[testenv:typing]
-extras = typing
-commands = mypy