diff --git a/pandas/tests/dtypes/test_dtypes.py b/pandas/tests/dtypes/test_dtypes.py
index aef61045179ef..e127fe27b6209 100644
--- a/pandas/tests/dtypes/test_dtypes.py
+++ b/pandas/tests/dtypes/test_dtypes.py
@@ -1140,3 +1140,15 @@ def test_compare_complex_dtypes():
 
     with pytest.raises(TypeError, match=msg):
         df.lt(df.astype(object))
+
+
+def test_multi_column_dtype_assignment():
+    # GH #27583
+    df = pd.DataFrame({"a": [0.0], "b": 0.0})
+    expected = pd.DataFrame({"a": [0], "b": 0})
+
+    df[["a", "b"]] = 0
+    tm.assert_frame_equal(df, expected)
+
+    df["b"] = 0
+    tm.assert_frame_equal(df, expected)