diff --git a/pandas/core/internals/blocks.py b/pandas/core/internals/blocks.py
index 386aee102cbcd..4f530ffc5ed5d 100644
--- a/pandas/core/internals/blocks.py
+++ b/pandas/core/internals/blocks.py
@@ -926,7 +926,7 @@ def setitem(self, indexer, value):
         value = extract_array(value, extract_numpy=True)
         try:
             casted = np_can_hold_element(values.dtype, value)
-        except ValueError:
+        except LossySetitemError:
             # current dtype cannot store value, coerce to common dtype
             nb = self.coerce_to_target_dtype(value)
             return nb.setitem(indexer, value)