diff --git a/pandas-stubs/core/frame.pyi b/pandas-stubs/core/frame.pyi
index 2b812a17f..203190707 100644
--- a/pandas-stubs/core/frame.pyi
+++ b/pandas-stubs/core/frame.pyi
@@ -138,17 +138,10 @@ class _LocIndexerFrame(_LocIndexer):
     @overload
     def __getitem__(
         self,
-        idx: Union[int, StrLike],
-    ) -> Series: ...
-    @overload
-    def __getitem__(
-        self,
-        idx: Tuple[Union[IndexType, MaskType], StrLike],
-    ) -> Series: ...
-    @overload
-    def __getitem__(
-        self,
-        idx: Tuple[Tuple[slice, ...], StrLike],
+        idx: Union[
+            Union[ScalarT, None],
+            Tuple[Union[IndexType, MaskType, Tuple[slice, ...]], Union[ScalarT, None]],
+        ],
     ) -> Series: ...
     @overload
     def __setitem__(
diff --git a/tests/test_frame.py b/tests/test_frame.py
index 6d7731f01..b76df3b4e 100644
--- a/tests/test_frame.py
+++ b/tests/test_frame.py
@@ -1,5 +1,5 @@
 # flake8: noqa: F841
-from datetime import date
+import datetime
 import io
 from pathlib import Path
 import tempfile
@@ -943,7 +943,7 @@ def test_types_regressions() -> None:
     ss2: pd.Series = pd.concat([s1, s2])
 
     # https://github.com/microsoft/python-type-stubs/issues/110
-    d: date = pd.Timestamp("2021-01-01")
+    d: datetime.date = pd.Timestamp("2021-01-01")
     tslist: List[pd.Timestamp] = list(pd.to_datetime(["2022-01-01", "2022-01-02"]))
     sseries: pd.Series = pd.Series(tslist)
     sseries_plus1: pd.Series = sseries + pd.Timedelta(1, "d")
@@ -1180,3 +1180,72 @@ def test_columns_mixlist() -> None:
     key: List[Union[int, str]]
     key = [1]
     check(assert_type(df[key], pd.DataFrame), pd.DataFrame)
+
+
+def test_frame_scalars_slice() -> None:
+    # GH 133
+    # scalars:
+    # str, bytes, datetime.date, datetime.datetime, datetime.timedelta, bool, int,
+    # float, complex, Timestamp, Timedelta
+
+    str_ = "a"
+    bytes_ = b"7"
+    date = datetime.date(1999, 12, 31)
+    datetime_ = datetime.datetime(1999, 12, 31)
+    timedelta = datetime.datetime(2000, 1, 1) - datetime.datetime(1999, 12, 31)
+    bool_ = True
+    int_ = 2
+    float_ = 3.14
+    complex_ = 1.0 + 3.0j
+    timestamp = pd.Timestamp(0)
+    pd_timedelta = pd.Timedelta(0, unit="D")
+    none = None
+    idx = [
+        str_,
+        bytes_,
+        date,
+        datetime_,
+        timedelta,
+        bool_,
+        int_,
+        float_,
+        complex_,
+        timestamp,
+        pd_timedelta,
+        none,
+    ]
+    values = np.arange(len(idx))[:, None] + np.arange(len(idx))
+    df = pd.DataFrame(values, columns=idx, index=idx)
+
+    # Note: bool_ cannot be tested since the index is object and pandas does not
+    # support boolean access using loc except when the index is boolean
+    check(assert_type(df.loc[str_], pd.Series), pd.Series)
+    check(assert_type(df.loc[bytes_], pd.Series), pd.Series)
+    check(assert_type(df.loc[date], pd.Series), pd.Series)
+    check(assert_type(df.loc[datetime_], pd.Series), pd.Series)
+    check(assert_type(df.loc[timedelta], pd.Series), pd.Series)
+    check(assert_type(df.loc[int_], pd.Series), pd.Series)
+    check(assert_type(df.loc[float_], pd.Series), pd.Series)
+    check(assert_type(df.loc[complex_], pd.Series), pd.Series)
+    check(assert_type(df.loc[timestamp], pd.Series), pd.Series)
+    check(assert_type(df.loc[pd_timedelta], pd.Series), pd.Series)
+    check(assert_type(df.loc[none], pd.Series), pd.Series)
+
+    check(assert_type(df.loc[:, str_], pd.Series), pd.Series)
+    check(assert_type(df.loc[:, bytes_], pd.Series), pd.Series)
+    check(assert_type(df.loc[:, date], pd.Series), pd.Series)
+    check(assert_type(df.loc[:, datetime_], pd.Series), pd.Series)
+    check(assert_type(df.loc[:, timedelta], pd.Series), pd.Series)
+    check(assert_type(df.loc[:, int_], pd.Series), pd.Series)
+    check(assert_type(df.loc[:, float_], pd.Series), pd.Series)
+    check(assert_type(df.loc[:, complex_], pd.Series), pd.Series)
+    check(assert_type(df.loc[:, timestamp], pd.Series), pd.Series)
+    check(assert_type(df.loc[:, pd_timedelta], pd.Series), pd.Series)
+    check(assert_type(df.loc[:, none], pd.Series), pd.Series)
+
+
+def test_boolean_loc() -> None:
+    # Booleans can only be used in loc when the index is boolean
+    df = pd.DataFrame([[0, 1], [1, 0]], columns=[True, False], index=[True, False])
+    check(assert_type(df.loc[True], pd.Series), pd.Series)
+    check(assert_type(df.loc[:, False], pd.Series), pd.Series)