diff --git a/news/1 Enhancements/18479.md b/news/1 Enhancements/18479.md
new file mode 100644
index 000000000000..c28a2f051112
--- /dev/null
+++ b/news/1 Enhancements/18479.md	
@@ -0,0 +1 @@
+Use `conda run` for conda environments for running python files and installing modules.
diff --git a/src/client/common/process/pythonEnvironment.ts b/src/client/common/process/pythonEnvironment.ts
index e162eb6da5a1..dfa74cbff922 100644
--- a/src/client/common/process/pythonEnvironment.ts
+++ b/src/client/common/process/pythonEnvironment.ts
@@ -149,9 +149,13 @@ export async function createCondaEnv(
     // These are used to generate the deps.
     procs: IProcessService,
     fs: IFileSystem,
+    executeAsAProcess?: boolean,
 ): Promise<PythonEnvironment | undefined> {
     const conda = await Conda.getConda();
-    const pythonArgv = await conda?.getRunPythonArgs({ name: condaInfo.name, prefix: condaInfo.path });
+    const pythonArgv = await conda?.getRunPythonArgs(
+        { name: condaInfo.name, prefix: condaInfo.path },
+        executeAsAProcess,
+    );
     if (!pythonArgv) {
         return undefined;
     }
diff --git a/src/client/common/process/pythonExecutionFactory.ts b/src/client/common/process/pythonExecutionFactory.ts
index 3bd167da0926..e5c8ea6aabcc 100644
--- a/src/client/common/process/pythonExecutionFactory.ts
+++ b/src/client/common/process/pythonExecutionFactory.ts
@@ -77,7 +77,11 @@ export class PythonExecutionFactory implements IPythonExecutionFactory {
         }
         const processService: IProcessService = await this.processServiceFactory.create(options.resource);
 
-        const condaExecutionService = await this.createCondaExecutionService(pythonPath, processService);
+        const condaExecutionService = await this.createCondaExecutionService(
+            pythonPath,
+            processService,
+            options.executeAsAProcess,
+        );
         if (condaExecutionService) {
             return condaExecutionService;
         }
@@ -125,13 +129,20 @@ export class PythonExecutionFactory implements IPythonExecutionFactory {
     public async createCondaExecutionService(
         pythonPath: string,
         processService: IProcessService,
+        executeAsAProcess?: boolean,
     ): Promise<IPythonExecutionService | undefined> {
         const condaLocatorService = this.serviceContainer.get<IComponentAdapter>(IComponentAdapter);
         const [condaEnvironment] = await Promise.all([condaLocatorService.getCondaEnvironment(pythonPath)]);
         if (!condaEnvironment) {
             return undefined;
         }
-        const env = await createCondaEnv(condaEnvironment, pythonPath, processService, this.fileSystem);
+        const env = await createCondaEnv(
+            condaEnvironment,
+            pythonPath,
+            processService,
+            this.fileSystem,
+            executeAsAProcess,
+        );
         if (!env) {
             return undefined;
         }
diff --git a/src/client/common/process/types.ts b/src/client/common/process/types.ts
index a5884ddd75fa..226341f4ae78 100644
--- a/src/client/common/process/types.ts
+++ b/src/client/common/process/types.ts
@@ -65,6 +65,10 @@ export const IPythonExecutionFactory = Symbol('IPythonExecutionFactory');
 export type ExecutionFactoryCreationOptions = {
     resource?: Uri;
     pythonPath?: string;
+    /**
+     * Whether to execute using `NodeJS.child_process` API, considered `true` as default.
+     */
+    executeAsAProcess?: boolean;
 };
 export type ExecutionFactoryCreateWithEnvironmentOptions = {
     resource?: Uri;
diff --git a/src/client/pythonEnvironments/common/environmentManagers/conda.ts b/src/client/pythonEnvironments/common/environmentManagers/conda.ts
index 332dee3f626f..abc440fc524d 100644
--- a/src/client/pythonEnvironments/common/environmentManagers/conda.ts
+++ b/src/client/pythonEnvironments/common/environmentManagers/conda.ts
@@ -405,7 +405,7 @@ export class Conda {
         return envList.find((e) => isParentPath(executable, e.prefix));
     }
 
-    public async getRunPythonArgs(env: CondaEnvInfo): Promise<string[] | undefined> {
+    public async getRunPythonArgs(env: CondaEnvInfo, executeAsAProcess = true): Promise<string[] | undefined> {
         const condaVersion = await this.getCondaVersion();
         if (condaVersion && lt(condaVersion, CONDA_RUN_VERSION)) {
             return undefined;
@@ -416,7 +416,11 @@ export class Conda {
         } else {
             args.push('-p', env.prefix);
         }
-        return [this.command, 'run', ...args, '--no-capture-output', '--live-stream', 'python', OUTPUT_MARKER_SCRIPT];
+        const pythonArgs = [this.command, 'run', ...args, '--no-capture-output', '--live-stream', 'python'];
+        if (executeAsAProcess) {
+            pythonArgs.push(OUTPUT_MARKER_SCRIPT);
+        }
+        return pythonArgs;
     }
 
     /**
diff --git a/src/client/terminals/codeExecution/djangoShellCodeExecution.ts b/src/client/terminals/codeExecution/djangoShellCodeExecution.ts
index 61f4cef7758f..649848daf426 100644
--- a/src/client/terminals/codeExecution/djangoShellCodeExecution.ts
+++ b/src/client/terminals/codeExecution/djangoShellCodeExecution.ts
@@ -9,6 +9,7 @@ import { Disposable, Uri } from 'vscode';
 import { ICommandManager, IDocumentManager, IWorkspaceService } from '../../common/application/types';
 import '../../common/extensions';
 import { IFileSystem, IPlatformService } from '../../common/platform/types';
+import { IPythonExecutionFactory } from '../../common/process/types';
 import { ITerminalServiceFactory } from '../../common/terminal/types';
 import { IConfigurationService, IDisposableRegistry } from '../../common/types';
 import { copyPythonExecInfo, PythonExecInfo } from '../../pythonEnvironments/exec';
@@ -26,8 +27,16 @@ export class DjangoShellCodeExecutionProvider extends TerminalCodeExecutionProvi
         @inject(ICommandManager) commandManager: ICommandManager,
         @inject(IFileSystem) fileSystem: IFileSystem,
         @inject(IDisposableRegistry) disposableRegistry: Disposable[],
+        @inject(IPythonExecutionFactory) pythonExecutionFactory: IPythonExecutionFactory,
     ) {
-        super(terminalServiceFactory, configurationService, workspace, disposableRegistry, platformService);
+        super(
+            terminalServiceFactory,
+            configurationService,
+            workspace,
+            disposableRegistry,
+            platformService,
+            pythonExecutionFactory,
+        );
         this.terminalTitle = 'Django Shell';
         disposableRegistry.push(new DjangoContextInitializer(documentManager, workspace, fileSystem, commandManager));
     }
diff --git a/src/client/terminals/codeExecution/repl.ts b/src/client/terminals/codeExecution/repl.ts
index fe5f5860bb28..69226c23dedf 100644
--- a/src/client/terminals/codeExecution/repl.ts
+++ b/src/client/terminals/codeExecution/repl.ts
@@ -7,6 +7,7 @@ import { inject, injectable } from 'inversify';
 import { Disposable } from 'vscode';
 import { IWorkspaceService } from '../../common/application/types';
 import { IPlatformService } from '../../common/platform/types';
+import { IPythonExecutionFactory } from '../../common/process/types';
 import { ITerminalServiceFactory } from '../../common/terminal/types';
 import { IConfigurationService, IDisposableRegistry } from '../../common/types';
 import { TerminalCodeExecutionProvider } from './terminalCodeExecution';
@@ -19,8 +20,16 @@ export class ReplProvider extends TerminalCodeExecutionProvider {
         @inject(IWorkspaceService) workspace: IWorkspaceService,
         @inject(IDisposableRegistry) disposableRegistry: Disposable[],
         @inject(IPlatformService) platformService: IPlatformService,
+        @inject(IPythonExecutionFactory) pythonExecutionFactory: IPythonExecutionFactory,
     ) {
-        super(terminalServiceFactory, configurationService, workspace, disposableRegistry, platformService);
+        super(
+            terminalServiceFactory,
+            configurationService,
+            workspace,
+            disposableRegistry,
+            platformService,
+            pythonExecutionFactory,
+        );
         this.terminalTitle = 'REPL';
     }
 }
diff --git a/src/client/terminals/codeExecution/terminalCodeExecution.ts b/src/client/terminals/codeExecution/terminalCodeExecution.ts
index 88eff107f791..a1d9e01812ff 100644
--- a/src/client/terminals/codeExecution/terminalCodeExecution.ts
+++ b/src/client/terminals/codeExecution/terminalCodeExecution.ts
@@ -9,6 +9,7 @@ import { Disposable, Uri } from 'vscode';
 import { IWorkspaceService } from '../../common/application/types';
 import '../../common/extensions';
 import { IPlatformService } from '../../common/platform/types';
+import { IPythonExecutionFactory } from '../../common/process/types';
 import { ITerminalService, ITerminalServiceFactory } from '../../common/terminal/types';
 import { IConfigurationService, IDisposableRegistry } from '../../common/types';
 import { buildPythonExecInfo, PythonExecInfo } from '../../pythonEnvironments/exec';
@@ -26,6 +27,7 @@ export class TerminalCodeExecutionProvider implements ICodeExecutionService {
         @inject(IWorkspaceService) protected readonly workspace: IWorkspaceService,
         @inject(IDisposableRegistry) protected readonly disposables: Disposable[],
         @inject(IPlatformService) protected readonly platformService: IPlatformService,
+        @inject(IPythonExecutionFactory) private readonly pythonExecutionFactory: IPythonExecutionFactory,
     ) {}
 
     public async executeFile(file: Uri) {
@@ -61,11 +63,12 @@ export class TerminalCodeExecutionProvider implements ICodeExecutionService {
 
     public async getExecutableInfo(resource?: Uri, args: string[] = []): Promise<PythonExecInfo> {
         const pythonSettings = this.configurationService.getSettings(resource);
-        const command = this.platformService.isWindows
-            ? pythonSettings.pythonPath.replace(/\\/g, '/')
-            : pythonSettings.pythonPath;
+        const executionFactory = await this.pythonExecutionFactory.create({ resource, executeAsAProcess: false });
+        const execInfo = executionFactory.getExecutionInfo();
+        const pythonArgs = execInfo.args;
+        const command = this.platformService.isWindows ? execInfo.command.replace(/\\/g, '/') : execInfo.command;
         const launchArgs = pythonSettings.terminal.launchArgs;
-        return buildPythonExecInfo(command, [...launchArgs, ...args]);
+        return buildPythonExecInfo(command, [...pythonArgs, ...launchArgs, ...args]);
     }
 
     // Overridden in subclasses, see djangoShellCodeExecution.ts
diff --git a/src/test/terminals/codeExecution/djangoShellCodeExect.unit.test.ts b/src/test/terminals/codeExecution/djangoShellCodeExect.unit.test.ts
index c0f5e50e0e1f..c6a106db03ea 100644
--- a/src/test/terminals/codeExecution/djangoShellCodeExect.unit.test.ts
+++ b/src/test/terminals/codeExecution/djangoShellCodeExect.unit.test.ts
@@ -57,6 +57,7 @@ suite('Terminal - Django Shell Code Execution', () => {
             commandManager.object,
             fileSystem.object,
             disposables,
+            pythonExecutionFactory.object,
         );
 
         terminalFactory.setup((f) => f.getTerminalService(TypeMoq.It.isAny())).returns(() => terminalService.object);
diff --git a/src/test/terminals/codeExecution/terminalCodeExec.unit.test.ts b/src/test/terminals/codeExecution/terminalCodeExec.unit.test.ts
index 4a02c75efc81..a9d2fa35c0ae 100644
--- a/src/test/terminals/codeExecution/terminalCodeExec.unit.test.ts
+++ b/src/test/terminals/codeExecution/terminalCodeExec.unit.test.ts
@@ -59,6 +59,7 @@ suite('Terminal - Code Execution', () => {
             terminalFactory = TypeMoq.Mock.ofType<ITerminalServiceFactory>();
             terminalSettings = TypeMoq.Mock.ofType<ITerminalSettings>();
             terminalService = TypeMoq.Mock.ofType<ITerminalService>();
+            pythonExecutionFactory = TypeMoq.Mock.ofType<IPythonExecutionFactory>();
             const configService = TypeMoq.Mock.ofType<IConfigurationService>();
             workspace = TypeMoq.Mock.ofType<IWorkspaceService>();
             platform = TypeMoq.Mock.ofType<IPlatformService>();
@@ -66,7 +67,6 @@ suite('Terminal - Code Execution', () => {
             documentManager = TypeMoq.Mock.ofType<IDocumentManager>();
             commandManager = TypeMoq.Mock.ofType<ICommandManager>();
             fileSystem = TypeMoq.Mock.ofType<IFileSystem>();
-            pythonExecutionFactory = TypeMoq.Mock.ofType<IPythonExecutionFactory>();
             settings = TypeMoq.Mock.ofType<IPythonSettings>();
             settings.setup((s) => s.terminal).returns(() => terminalSettings.object);
             configService.setup((c) => c.getSettings(TypeMoq.It.isAny())).returns(() => settings.object);
@@ -79,6 +79,7 @@ suite('Terminal - Code Execution', () => {
                         workspace.object,
                         disposables,
                         platform.object,
+                        pythonExecutionFactory.object,
                     );
                     break;
                 }
@@ -89,6 +90,7 @@ suite('Terminal - Code Execution', () => {
                         workspace.object,
                         disposables,
                         platform.object,
+                        pythonExecutionFactory.object,
                     );
                     expectedTerminalTitle = 'REPL';
                     break;
@@ -111,6 +113,7 @@ suite('Terminal - Code Execution', () => {
                         commandManager.object,
                         fileSystem.object,
                         disposables,
+                        pythonExecutionFactory.object,
                     );
                     expectedTerminalTitle = 'Django Shell';
                     break;