diff --git a/src/compiler/checker.ts b/src/compiler/checker.ts
index b975b9848853d..a21693a55b4d9 100644
--- a/src/compiler/checker.ts
+++ b/src/compiler/checker.ts
@@ -22429,7 +22429,7 @@ export function createTypeChecker(host: TypeCheckerHost): TypeChecker {
             const targetHasStringIndex = some(indexInfos, info => info.keyType === stringType);
             let result = Ternary.True;
             for (const targetInfo of indexInfos) {
-                const related = !sourceIsPrimitive && targetHasStringIndex && targetInfo.type.flags & TypeFlags.Any ? Ternary.True :
+                const related = relation !== strictSubtypeRelation && !sourceIsPrimitive && targetHasStringIndex && targetInfo.type.flags & TypeFlags.Any ? Ternary.True :
                     isGenericMappedType(source) && targetHasStringIndex ? isRelatedTo(getTemplateTypeFromMappedType(source), targetInfo.type, RecursionFlags.Both, reportErrors) :
                     typeRelatedToIndexInfo(source, targetInfo, reportErrors, intersectionState);
                 if (!related) {
diff --git a/tests/baselines/reference/narrowingMutualSubtypes.errors.txt b/tests/baselines/reference/narrowingMutualSubtypes.errors.txt
new file mode 100644
index 0000000000000..8f65deade7c12
--- /dev/null
+++ b/tests/baselines/reference/narrowingMutualSubtypes.errors.txt
@@ -0,0 +1,155 @@
+tests/cases/compiler/narrowingMutualSubtypes.ts(117,17): error TS7053: Element implicitly has an 'any' type because expression of type 'string' can't be used to index type 'any[] | Record<string, any>'.
+  No index signature with a parameter of type 'string' was found on type 'any[] | Record<string, any>'.
+tests/cases/compiler/narrowingMutualSubtypes.ts(118,29): error TS7053: Element implicitly has an 'any' type because expression of type 'string' can't be used to index type 'any[] | Record<string, any>'.
+  No index signature with a parameter of type 'string' was found on type 'any[] | Record<string, any>'.
+
+
+==== tests/cases/compiler/narrowingMutualSubtypes.ts (2 errors) ====
+    // Check that `any` is a strict supertype of `unknown`
+    
+    declare const ru1: { [x: string]: unknown };
+    declare const ra1: { [x: string]: any };
+    
+    const a1a = [ru1, ra1];  // { [x: string]: any }[]
+    const a1b = [ra1, ru1];  // { [x: string]: any }[]
+    
+    declare const ra2: { [x: string]: any };
+    declare const ru2: { [x: string]: unknown };
+    
+    const a2a = [ru2, ra2];  // { [x: string]: any }[]
+    const a2b = [ra2, ru2];  // { [x: string]: any }[]
+    
+    // Check that `{}` is strict supertype of any non-empty object
+    
+    const c3 = {};
+    declare const r3: { [x: string]: unknown }
+    
+    const a3a = [c3, r3];  // {}[]
+    const a3b = [r3, c3];  // {}[]
+    
+    declare const r4: { [x: string]: unknown }
+    const c4 = {};
+    
+    const a4a = [c4, r4];  // {}[]
+    const a4b = [r4, c4];  // {}[]
+    
+    // Check that {} is a strict supertype of Record<string, unknown>
+    
+    declare function isObject1(value: unknown): value is Record<string, unknown>;
+    
+    function gg1(x: {}) {
+        if (isObject1(x)) {
+            x;  // Record<string, unknown>
+        }
+        else {
+            x;  // {}
+        }
+        x;  // {}
+    }
+    
+    declare function isObject2(value: unknown): value is {};
+    
+    function gg2(x: Record<string, unknown>) {
+        if (isObject2(x)) {
+            x;  // Record<string, unknown>
+        }
+        else {
+            x;  // never
+        }
+        x;  // Record<string, unknown>
+    }
+    
+    // Check that {} is a strict supertype of Record<string, any>
+    
+    declare function isObject3(value: unknown): value is Record<string, any>;
+    
+    function gg3(x: {}) {
+        if (isObject3(x)) {
+            x;  // Record<string, any>
+        }
+        else {
+            x;  // {}
+        }
+        x;  // {}
+    }
+    
+    declare function isObject4(value: unknown): value is {};
+    
+    function gg4(x: Record<string, any>) {
+        if (isObject4(x)) {
+            x;  // Record<string, any>
+        }
+        else {
+            x;  // never
+        }
+        x;  // Record<string, any>
+    }
+    
+    // Repro from #50916
+    
+    type Identity<T> = {[K in keyof T]: T[K]};
+    
+    type Self<T> = T extends unknown ? Identity<T> : never;
+    
+    function is<T>(value: T): value is Self<T> {
+        return true;
+    }
+    
+    type Union =  {a: number} | {b: number} | {c: number};
+    
+    function example(x: Union) {
+        if (is(x)) {}
+        if (is(x)) {}
+        if (is(x)) {}
+        if (is(x)) {}
+        if (is(x)) {}
+        if (is(x)) {}
+        if (is(x)) {}
+        if (is(x)) {}
+        x;  // Union
+    }
+    
+    function checksArrayOrObject1(obj: Record<string, any> | Record<string, any>[]) {
+        // "accidentally" guards the first branch on the length
+        if (Array.isArray(obj) && obj.length) {
+            for (let key in obj) {
+                if (obj[key] !== undefined) {
+                    console.log(obj[key])
+                }
+            }
+        }
+        else {
+            // 'obj' should probably not include an array type here.
+            for (let key in obj) {
+                if (obj[key] !== undefined) {
+                    ~~~~~~~~
+!!! error TS7053: Element implicitly has an 'any' type because expression of type 'string' can't be used to index type 'any[] | Record<string, any>'.
+!!! error TS7053:   No index signature with a parameter of type 'string' was found on type 'any[] | Record<string, any>'.
+                    console.log(obj[key])
+                                ~~~~~~~~
+!!! error TS7053: Element implicitly has an 'any' type because expression of type 'string' can't be used to index type 'any[] | Record<string, any>'.
+!!! error TS7053:   No index signature with a parameter of type 'string' was found on type 'any[] | Record<string, any>'.
+                }
+            }
+        }
+    }
+    
+    function checksArrayOrObject2(obj: Record<string, any> | Record<string, any>[]) {
+        if (Array.isArray(obj)) {
+            // obj should only be an array type here
+            for (let key in obj) {
+                if (obj[key] !== undefined) {
+                    console.log(obj[key])
+                }
+            }
+        }
+        else {
+            // 'obj' should probably not include an array type here.
+            for (let key in obj) {
+                if (obj[key] !== undefined) {
+                    console.log(obj[key])
+                }
+            }
+        }
+    }
+    
\ No newline at end of file
diff --git a/tests/baselines/reference/narrowingMutualSubtypes.js b/tests/baselines/reference/narrowingMutualSubtypes.js
index 0d5f36d2f9551..69faca4689f3d 100644
--- a/tests/baselines/reference/narrowingMutualSubtypes.js
+++ b/tests/baselines/reference/narrowingMutualSubtypes.js
@@ -27,11 +27,11 @@ const c4 = {};
 const a4a = [c4, r4];  // {}[]
 const a4b = [r4, c4];  // {}[]
 
-// Check that narrowing preserves original type in false branch for non-identical mutual subtypes
+// Check that {} is a strict supertype of Record<string, unknown>
 
 declare function isObject1(value: unknown): value is Record<string, unknown>;
 
-function gg(x: {}) {
+function gg1(x: {}) {
     if (isObject1(x)) {
         x;  // Record<string, unknown>
     }
@@ -45,14 +45,40 @@ declare function isObject2(value: unknown): value is {};
 
 function gg2(x: Record<string, unknown>) {
     if (isObject2(x)) {
-        x;  // {}
+        x;  // Record<string, unknown>
     }
     else {
-        x;  // Record<string, unknown>
+        x;  // never
     }
     x;  // Record<string, unknown>
 }
 
+// Check that {} is a strict supertype of Record<string, any>
+
+declare function isObject3(value: unknown): value is Record<string, any>;
+
+function gg3(x: {}) {
+    if (isObject3(x)) {
+        x;  // Record<string, any>
+    }
+    else {
+        x;  // {}
+    }
+    x;  // {}
+}
+
+declare function isObject4(value: unknown): value is {};
+
+function gg4(x: Record<string, any>) {
+    if (isObject4(x)) {
+        x;  // Record<string, any>
+    }
+    else {
+        x;  // never
+    }
+    x;  // Record<string, any>
+}
+
 // Repro from #50916
 
 type Identity<T> = {[K in keyof T]: T[K]};
@@ -76,6 +102,44 @@ function example(x: Union) {
     if (is(x)) {}
     x;  // Union
 }
+
+function checksArrayOrObject1(obj: Record<string, any> | Record<string, any>[]) {
+    // "accidentally" guards the first branch on the length
+    if (Array.isArray(obj) && obj.length) {
+        for (let key in obj) {
+            if (obj[key] !== undefined) {
+                console.log(obj[key])
+            }
+        }
+    }
+    else {
+        // 'obj' should probably not include an array type here.
+        for (let key in obj) {
+            if (obj[key] !== undefined) {
+                console.log(obj[key])
+            }
+        }
+    }
+}
+
+function checksArrayOrObject2(obj: Record<string, any> | Record<string, any>[]) {
+    if (Array.isArray(obj)) {
+        // obj should only be an array type here
+        for (let key in obj) {
+            if (obj[key] !== undefined) {
+                console.log(obj[key])
+            }
+        }
+    }
+    else {
+        // 'obj' should probably not include an array type here.
+        for (let key in obj) {
+            if (obj[key] !== undefined) {
+                console.log(obj[key])
+            }
+        }
+    }
+}
 
 
 //// [narrowingMutualSubtypes.js]
@@ -92,7 +156,7 @@ var a3b = [r3, c3]; // {}[]
 var c4 = {};
 var a4a = [c4, r4]; // {}[]
 var a4b = [r4, c4]; // {}[]
-function gg(x) {
+function gg1(x) {
     if (isObject1(x)) {
         x; // Record<string, unknown>
     }
@@ -103,13 +167,31 @@ function gg(x) {
 }
 function gg2(x) {
     if (isObject2(x)) {
-        x; // {}
+        x; // Record<string, unknown>
     }
     else {
-        x; // Record<string, unknown>
+        x; // never
     }
     x; // Record<string, unknown>
 }
+function gg3(x) {
+    if (isObject3(x)) {
+        x; // Record<string, any>
+    }
+    else {
+        x; // {}
+    }
+    x; // {}
+}
+function gg4(x) {
+    if (isObject4(x)) {
+        x; // Record<string, any>
+    }
+    else {
+        x; // never
+    }
+    x; // Record<string, any>
+}
 function is(value) {
     return true;
 }
@@ -124,3 +206,39 @@ function example(x) {
     if (is(x)) { }
     x; // Union
 }
+function checksArrayOrObject1(obj) {
+    // "accidentally" guards the first branch on the length
+    if (Array.isArray(obj) && obj.length) {
+        for (var key in obj) {
+            if (obj[key] !== undefined) {
+                console.log(obj[key]);
+            }
+        }
+    }
+    else {
+        // 'obj' should probably not include an array type here.
+        for (var key in obj) {
+            if (obj[key] !== undefined) {
+                console.log(obj[key]);
+            }
+        }
+    }
+}
+function checksArrayOrObject2(obj) {
+    if (Array.isArray(obj)) {
+        // obj should only be an array type here
+        for (var key in obj) {
+            if (obj[key] !== undefined) {
+                console.log(obj[key]);
+            }
+        }
+    }
+    else {
+        // 'obj' should probably not include an array type here.
+        for (var key in obj) {
+            if (obj[key] !== undefined) {
+                console.log(obj[key]);
+            }
+        }
+    }
+}
diff --git a/tests/baselines/reference/narrowingMutualSubtypes.symbols b/tests/baselines/reference/narrowingMutualSubtypes.symbols
index 9229c0b6e2946..a08534ac2a31c 100644
--- a/tests/baselines/reference/narrowingMutualSubtypes.symbols
+++ b/tests/baselines/reference/narrowingMutualSubtypes.symbols
@@ -73,7 +73,7 @@ const a4b = [r4, c4];  // {}[]
 >r4 : Symbol(r4, Decl(narrowingMutualSubtypes.ts, 22, 13))
 >c4 : Symbol(c4, Decl(narrowingMutualSubtypes.ts, 23, 5))
 
-// Check that narrowing preserves original type in false branch for non-identical mutual subtypes
+// Check that {} is a strict supertype of Record<string, unknown>
 
 declare function isObject1(value: unknown): value is Record<string, unknown>;
 >isObject1 : Symbol(isObject1, Decl(narrowingMutualSubtypes.ts, 26, 21))
@@ -81,23 +81,23 @@ declare function isObject1(value: unknown): value is Record<string, unknown>;
 >value : Symbol(value, Decl(narrowingMutualSubtypes.ts, 30, 27))
 >Record : Symbol(Record, Decl(lib.es5.d.ts, --, --))
 
-function gg(x: {}) {
->gg : Symbol(gg, Decl(narrowingMutualSubtypes.ts, 30, 77))
->x : Symbol(x, Decl(narrowingMutualSubtypes.ts, 32, 12))
+function gg1(x: {}) {
+>gg1 : Symbol(gg1, Decl(narrowingMutualSubtypes.ts, 30, 77))
+>x : Symbol(x, Decl(narrowingMutualSubtypes.ts, 32, 13))
 
     if (isObject1(x)) {
 >isObject1 : Symbol(isObject1, Decl(narrowingMutualSubtypes.ts, 26, 21))
->x : Symbol(x, Decl(narrowingMutualSubtypes.ts, 32, 12))
+>x : Symbol(x, Decl(narrowingMutualSubtypes.ts, 32, 13))
 
         x;  // Record<string, unknown>
->x : Symbol(x, Decl(narrowingMutualSubtypes.ts, 32, 12))
+>x : Symbol(x, Decl(narrowingMutualSubtypes.ts, 32, 13))
     }
     else {
         x;  // {}
->x : Symbol(x, Decl(narrowingMutualSubtypes.ts, 32, 12))
+>x : Symbol(x, Decl(narrowingMutualSubtypes.ts, 32, 13))
     }
     x;  // {}
->x : Symbol(x, Decl(narrowingMutualSubtypes.ts, 32, 12))
+>x : Symbol(x, Decl(narrowingMutualSubtypes.ts, 32, 13))
 }
 
 declare function isObject2(value: unknown): value is {};
@@ -114,90 +114,251 @@ function gg2(x: Record<string, unknown>) {
 >isObject2 : Symbol(isObject2, Decl(narrowingMutualSubtypes.ts, 40, 1))
 >x : Symbol(x, Decl(narrowingMutualSubtypes.ts, 44, 13))
 
-        x;  // {}
+        x;  // Record<string, unknown>
 >x : Symbol(x, Decl(narrowingMutualSubtypes.ts, 44, 13))
     }
     else {
-        x;  // Record<string, unknown>
+        x;  // never
 >x : Symbol(x, Decl(narrowingMutualSubtypes.ts, 44, 13))
     }
     x;  // Record<string, unknown>
 >x : Symbol(x, Decl(narrowingMutualSubtypes.ts, 44, 13))
 }
 
+// Check that {} is a strict supertype of Record<string, any>
+
+declare function isObject3(value: unknown): value is Record<string, any>;
+>isObject3 : Symbol(isObject3, Decl(narrowingMutualSubtypes.ts, 52, 1))
+>value : Symbol(value, Decl(narrowingMutualSubtypes.ts, 56, 27))
+>value : Symbol(value, Decl(narrowingMutualSubtypes.ts, 56, 27))
+>Record : Symbol(Record, Decl(lib.es5.d.ts, --, --))
+
+function gg3(x: {}) {
+>gg3 : Symbol(gg3, Decl(narrowingMutualSubtypes.ts, 56, 73))
+>x : Symbol(x, Decl(narrowingMutualSubtypes.ts, 58, 13))
+
+    if (isObject3(x)) {
+>isObject3 : Symbol(isObject3, Decl(narrowingMutualSubtypes.ts, 52, 1))
+>x : Symbol(x, Decl(narrowingMutualSubtypes.ts, 58, 13))
+
+        x;  // Record<string, any>
+>x : Symbol(x, Decl(narrowingMutualSubtypes.ts, 58, 13))
+    }
+    else {
+        x;  // {}
+>x : Symbol(x, Decl(narrowingMutualSubtypes.ts, 58, 13))
+    }
+    x;  // {}
+>x : Symbol(x, Decl(narrowingMutualSubtypes.ts, 58, 13))
+}
+
+declare function isObject4(value: unknown): value is {};
+>isObject4 : Symbol(isObject4, Decl(narrowingMutualSubtypes.ts, 66, 1))
+>value : Symbol(value, Decl(narrowingMutualSubtypes.ts, 68, 27))
+>value : Symbol(value, Decl(narrowingMutualSubtypes.ts, 68, 27))
+
+function gg4(x: Record<string, any>) {
+>gg4 : Symbol(gg4, Decl(narrowingMutualSubtypes.ts, 68, 56))
+>x : Symbol(x, Decl(narrowingMutualSubtypes.ts, 70, 13))
+>Record : Symbol(Record, Decl(lib.es5.d.ts, --, --))
+
+    if (isObject4(x)) {
+>isObject4 : Symbol(isObject4, Decl(narrowingMutualSubtypes.ts, 66, 1))
+>x : Symbol(x, Decl(narrowingMutualSubtypes.ts, 70, 13))
+
+        x;  // Record<string, any>
+>x : Symbol(x, Decl(narrowingMutualSubtypes.ts, 70, 13))
+    }
+    else {
+        x;  // never
+>x : Symbol(x, Decl(narrowingMutualSubtypes.ts, 70, 13))
+    }
+    x;  // Record<string, any>
+>x : Symbol(x, Decl(narrowingMutualSubtypes.ts, 70, 13))
+}
+
 // Repro from #50916
 
 type Identity<T> = {[K in keyof T]: T[K]};
->Identity : Symbol(Identity, Decl(narrowingMutualSubtypes.ts, 52, 1))
->T : Symbol(T, Decl(narrowingMutualSubtypes.ts, 56, 14))
->K : Symbol(K, Decl(narrowingMutualSubtypes.ts, 56, 21))
->T : Symbol(T, Decl(narrowingMutualSubtypes.ts, 56, 14))
->T : Symbol(T, Decl(narrowingMutualSubtypes.ts, 56, 14))
->K : Symbol(K, Decl(narrowingMutualSubtypes.ts, 56, 21))
+>Identity : Symbol(Identity, Decl(narrowingMutualSubtypes.ts, 78, 1))
+>T : Symbol(T, Decl(narrowingMutualSubtypes.ts, 82, 14))
+>K : Symbol(K, Decl(narrowingMutualSubtypes.ts, 82, 21))
+>T : Symbol(T, Decl(narrowingMutualSubtypes.ts, 82, 14))
+>T : Symbol(T, Decl(narrowingMutualSubtypes.ts, 82, 14))
+>K : Symbol(K, Decl(narrowingMutualSubtypes.ts, 82, 21))
 
 type Self<T> = T extends unknown ? Identity<T> : never;
->Self : Symbol(Self, Decl(narrowingMutualSubtypes.ts, 56, 42))
->T : Symbol(T, Decl(narrowingMutualSubtypes.ts, 58, 10))
->T : Symbol(T, Decl(narrowingMutualSubtypes.ts, 58, 10))
->Identity : Symbol(Identity, Decl(narrowingMutualSubtypes.ts, 52, 1))
->T : Symbol(T, Decl(narrowingMutualSubtypes.ts, 58, 10))
+>Self : Symbol(Self, Decl(narrowingMutualSubtypes.ts, 82, 42))
+>T : Symbol(T, Decl(narrowingMutualSubtypes.ts, 84, 10))
+>T : Symbol(T, Decl(narrowingMutualSubtypes.ts, 84, 10))
+>Identity : Symbol(Identity, Decl(narrowingMutualSubtypes.ts, 78, 1))
+>T : Symbol(T, Decl(narrowingMutualSubtypes.ts, 84, 10))
 
 function is<T>(value: T): value is Self<T> {
->is : Symbol(is, Decl(narrowingMutualSubtypes.ts, 58, 55))
->T : Symbol(T, Decl(narrowingMutualSubtypes.ts, 60, 12))
->value : Symbol(value, Decl(narrowingMutualSubtypes.ts, 60, 15))
->T : Symbol(T, Decl(narrowingMutualSubtypes.ts, 60, 12))
->value : Symbol(value, Decl(narrowingMutualSubtypes.ts, 60, 15))
->Self : Symbol(Self, Decl(narrowingMutualSubtypes.ts, 56, 42))
->T : Symbol(T, Decl(narrowingMutualSubtypes.ts, 60, 12))
+>is : Symbol(is, Decl(narrowingMutualSubtypes.ts, 84, 55))
+>T : Symbol(T, Decl(narrowingMutualSubtypes.ts, 86, 12))
+>value : Symbol(value, Decl(narrowingMutualSubtypes.ts, 86, 15))
+>T : Symbol(T, Decl(narrowingMutualSubtypes.ts, 86, 12))
+>value : Symbol(value, Decl(narrowingMutualSubtypes.ts, 86, 15))
+>Self : Symbol(Self, Decl(narrowingMutualSubtypes.ts, 82, 42))
+>T : Symbol(T, Decl(narrowingMutualSubtypes.ts, 86, 12))
 
     return true;
 }
 
 type Union =  {a: number} | {b: number} | {c: number};
->Union : Symbol(Union, Decl(narrowingMutualSubtypes.ts, 62, 1))
->a : Symbol(a, Decl(narrowingMutualSubtypes.ts, 64, 15))
->b : Symbol(b, Decl(narrowingMutualSubtypes.ts, 64, 29))
->c : Symbol(c, Decl(narrowingMutualSubtypes.ts, 64, 43))
+>Union : Symbol(Union, Decl(narrowingMutualSubtypes.ts, 88, 1))
+>a : Symbol(a, Decl(narrowingMutualSubtypes.ts, 90, 15))
+>b : Symbol(b, Decl(narrowingMutualSubtypes.ts, 90, 29))
+>c : Symbol(c, Decl(narrowingMutualSubtypes.ts, 90, 43))
 
 function example(x: Union) {
->example : Symbol(example, Decl(narrowingMutualSubtypes.ts, 64, 54))
->x : Symbol(x, Decl(narrowingMutualSubtypes.ts, 66, 17))
->Union : Symbol(Union, Decl(narrowingMutualSubtypes.ts, 62, 1))
+>example : Symbol(example, Decl(narrowingMutualSubtypes.ts, 90, 54))
+>x : Symbol(x, Decl(narrowingMutualSubtypes.ts, 92, 17))
+>Union : Symbol(Union, Decl(narrowingMutualSubtypes.ts, 88, 1))
 
     if (is(x)) {}
->is : Symbol(is, Decl(narrowingMutualSubtypes.ts, 58, 55))
->x : Symbol(x, Decl(narrowingMutualSubtypes.ts, 66, 17))
+>is : Symbol(is, Decl(narrowingMutualSubtypes.ts, 84, 55))
+>x : Symbol(x, Decl(narrowingMutualSubtypes.ts, 92, 17))
 
     if (is(x)) {}
->is : Symbol(is, Decl(narrowingMutualSubtypes.ts, 58, 55))
->x : Symbol(x, Decl(narrowingMutualSubtypes.ts, 66, 17))
+>is : Symbol(is, Decl(narrowingMutualSubtypes.ts, 84, 55))
+>x : Symbol(x, Decl(narrowingMutualSubtypes.ts, 92, 17))
 
     if (is(x)) {}
->is : Symbol(is, Decl(narrowingMutualSubtypes.ts, 58, 55))
->x : Symbol(x, Decl(narrowingMutualSubtypes.ts, 66, 17))
+>is : Symbol(is, Decl(narrowingMutualSubtypes.ts, 84, 55))
+>x : Symbol(x, Decl(narrowingMutualSubtypes.ts, 92, 17))
 
     if (is(x)) {}
->is : Symbol(is, Decl(narrowingMutualSubtypes.ts, 58, 55))
->x : Symbol(x, Decl(narrowingMutualSubtypes.ts, 66, 17))
+>is : Symbol(is, Decl(narrowingMutualSubtypes.ts, 84, 55))
+>x : Symbol(x, Decl(narrowingMutualSubtypes.ts, 92, 17))
 
     if (is(x)) {}
->is : Symbol(is, Decl(narrowingMutualSubtypes.ts, 58, 55))
->x : Symbol(x, Decl(narrowingMutualSubtypes.ts, 66, 17))
+>is : Symbol(is, Decl(narrowingMutualSubtypes.ts, 84, 55))
+>x : Symbol(x, Decl(narrowingMutualSubtypes.ts, 92, 17))
 
     if (is(x)) {}
->is : Symbol(is, Decl(narrowingMutualSubtypes.ts, 58, 55))
->x : Symbol(x, Decl(narrowingMutualSubtypes.ts, 66, 17))
+>is : Symbol(is, Decl(narrowingMutualSubtypes.ts, 84, 55))
+>x : Symbol(x, Decl(narrowingMutualSubtypes.ts, 92, 17))
 
     if (is(x)) {}
->is : Symbol(is, Decl(narrowingMutualSubtypes.ts, 58, 55))
->x : Symbol(x, Decl(narrowingMutualSubtypes.ts, 66, 17))
+>is : Symbol(is, Decl(narrowingMutualSubtypes.ts, 84, 55))
+>x : Symbol(x, Decl(narrowingMutualSubtypes.ts, 92, 17))
 
     if (is(x)) {}
->is : Symbol(is, Decl(narrowingMutualSubtypes.ts, 58, 55))
->x : Symbol(x, Decl(narrowingMutualSubtypes.ts, 66, 17))
+>is : Symbol(is, Decl(narrowingMutualSubtypes.ts, 84, 55))
+>x : Symbol(x, Decl(narrowingMutualSubtypes.ts, 92, 17))
 
     x;  // Union
->x : Symbol(x, Decl(narrowingMutualSubtypes.ts, 66, 17))
+>x : Symbol(x, Decl(narrowingMutualSubtypes.ts, 92, 17))
+}
+
+function checksArrayOrObject1(obj: Record<string, any> | Record<string, any>[]) {
+>checksArrayOrObject1 : Symbol(checksArrayOrObject1, Decl(narrowingMutualSubtypes.ts, 102, 1))
+>obj : Symbol(obj, Decl(narrowingMutualSubtypes.ts, 104, 30))
+>Record : Symbol(Record, Decl(lib.es5.d.ts, --, --))
+>Record : Symbol(Record, Decl(lib.es5.d.ts, --, --))
+
+    // "accidentally" guards the first branch on the length
+    if (Array.isArray(obj) && obj.length) {
+>Array.isArray : Symbol(ArrayConstructor.isArray, Decl(lib.es5.d.ts, --, --))
+>Array : Symbol(Array, Decl(lib.es5.d.ts, --, --), Decl(lib.es5.d.ts, --, --))
+>isArray : Symbol(ArrayConstructor.isArray, Decl(lib.es5.d.ts, --, --))
+>obj : Symbol(obj, Decl(narrowingMutualSubtypes.ts, 104, 30))
+>obj.length : Symbol(Array.length, Decl(lib.es5.d.ts, --, --))
+>obj : Symbol(obj, Decl(narrowingMutualSubtypes.ts, 104, 30))
+>length : Symbol(Array.length, Decl(lib.es5.d.ts, --, --))
+
+        for (let key in obj) {
+>key : Symbol(key, Decl(narrowingMutualSubtypes.ts, 107, 16))
+>obj : Symbol(obj, Decl(narrowingMutualSubtypes.ts, 104, 30))
+
+            if (obj[key] !== undefined) {
+>obj : Symbol(obj, Decl(narrowingMutualSubtypes.ts, 104, 30))
+>key : Symbol(key, Decl(narrowingMutualSubtypes.ts, 107, 16))
+>undefined : Symbol(undefined)
+
+                console.log(obj[key])
+>console.log : Symbol(Console.log, Decl(lib.dom.d.ts, --, --))
+>console : Symbol(console, Decl(lib.dom.d.ts, --, --))
+>log : Symbol(Console.log, Decl(lib.dom.d.ts, --, --))
+>obj : Symbol(obj, Decl(narrowingMutualSubtypes.ts, 104, 30))
+>key : Symbol(key, Decl(narrowingMutualSubtypes.ts, 107, 16))
+            }
+        }
+    }
+    else {
+        // 'obj' should probably not include an array type here.
+        for (let key in obj) {
+>key : Symbol(key, Decl(narrowingMutualSubtypes.ts, 115, 16))
+>obj : Symbol(obj, Decl(narrowingMutualSubtypes.ts, 104, 30))
+
+            if (obj[key] !== undefined) {
+>obj : Symbol(obj, Decl(narrowingMutualSubtypes.ts, 104, 30))
+>key : Symbol(key, Decl(narrowingMutualSubtypes.ts, 115, 16))
+>undefined : Symbol(undefined)
+
+                console.log(obj[key])
+>console.log : Symbol(Console.log, Decl(lib.dom.d.ts, --, --))
+>console : Symbol(console, Decl(lib.dom.d.ts, --, --))
+>log : Symbol(Console.log, Decl(lib.dom.d.ts, --, --))
+>obj : Symbol(obj, Decl(narrowingMutualSubtypes.ts, 104, 30))
+>key : Symbol(key, Decl(narrowingMutualSubtypes.ts, 115, 16))
+            }
+        }
+    }
+}
+
+function checksArrayOrObject2(obj: Record<string, any> | Record<string, any>[]) {
+>checksArrayOrObject2 : Symbol(checksArrayOrObject2, Decl(narrowingMutualSubtypes.ts, 121, 1))
+>obj : Symbol(obj, Decl(narrowingMutualSubtypes.ts, 123, 30))
+>Record : Symbol(Record, Decl(lib.es5.d.ts, --, --))
+>Record : Symbol(Record, Decl(lib.es5.d.ts, --, --))
+
+    if (Array.isArray(obj)) {
+>Array.isArray : Symbol(ArrayConstructor.isArray, Decl(lib.es5.d.ts, --, --))
+>Array : Symbol(Array, Decl(lib.es5.d.ts, --, --), Decl(lib.es5.d.ts, --, --))
+>isArray : Symbol(ArrayConstructor.isArray, Decl(lib.es5.d.ts, --, --))
+>obj : Symbol(obj, Decl(narrowingMutualSubtypes.ts, 123, 30))
+
+        // obj should only be an array type here
+        for (let key in obj) {
+>key : Symbol(key, Decl(narrowingMutualSubtypes.ts, 126, 16))
+>obj : Symbol(obj, Decl(narrowingMutualSubtypes.ts, 123, 30))
+
+            if (obj[key] !== undefined) {
+>obj : Symbol(obj, Decl(narrowingMutualSubtypes.ts, 123, 30))
+>key : Symbol(key, Decl(narrowingMutualSubtypes.ts, 126, 16))
+>undefined : Symbol(undefined)
+
+                console.log(obj[key])
+>console.log : Symbol(Console.log, Decl(lib.dom.d.ts, --, --))
+>console : Symbol(console, Decl(lib.dom.d.ts, --, --))
+>log : Symbol(Console.log, Decl(lib.dom.d.ts, --, --))
+>obj : Symbol(obj, Decl(narrowingMutualSubtypes.ts, 123, 30))
+>key : Symbol(key, Decl(narrowingMutualSubtypes.ts, 126, 16))
+            }
+        }
+    }
+    else {
+        // 'obj' should probably not include an array type here.
+        for (let key in obj) {
+>key : Symbol(key, Decl(narrowingMutualSubtypes.ts, 134, 16))
+>obj : Symbol(obj, Decl(narrowingMutualSubtypes.ts, 123, 30))
+
+            if (obj[key] !== undefined) {
+>obj : Symbol(obj, Decl(narrowingMutualSubtypes.ts, 123, 30))
+>key : Symbol(key, Decl(narrowingMutualSubtypes.ts, 134, 16))
+>undefined : Symbol(undefined)
+
+                console.log(obj[key])
+>console.log : Symbol(Console.log, Decl(lib.dom.d.ts, --, --))
+>console : Symbol(console, Decl(lib.dom.d.ts, --, --))
+>log : Symbol(Console.log, Decl(lib.dom.d.ts, --, --))
+>obj : Symbol(obj, Decl(narrowingMutualSubtypes.ts, 123, 30))
+>key : Symbol(key, Decl(narrowingMutualSubtypes.ts, 134, 16))
+            }
+        }
+    }
 }
 
diff --git a/tests/baselines/reference/narrowingMutualSubtypes.types b/tests/baselines/reference/narrowingMutualSubtypes.types
index 7ed2f5955d678..c335387467d23 100644
--- a/tests/baselines/reference/narrowingMutualSubtypes.types
+++ b/tests/baselines/reference/narrowingMutualSubtypes.types
@@ -83,14 +83,14 @@ const a4b = [r4, c4];  // {}[]
 >r4 : { [x: string]: unknown; }
 >c4 : {}
 
-// Check that narrowing preserves original type in false branch for non-identical mutual subtypes
+// Check that {} is a strict supertype of Record<string, unknown>
 
 declare function isObject1(value: unknown): value is Record<string, unknown>;
 >isObject1 : (value: unknown) => value is Record<string, unknown>
 >value : unknown
 
-function gg(x: {}) {
->gg : (x: {}) => void
+function gg1(x: {}) {
+>gg1 : (x: {}) => void
 >x : {}
 
     if (isObject1(x)) {
@@ -122,17 +122,67 @@ function gg2(x: Record<string, unknown>) {
 >isObject2 : (value: unknown) => value is {}
 >x : Record<string, unknown>
 
-        x;  // {}
+        x;  // Record<string, unknown>
 >x : Record<string, unknown>
     }
     else {
-        x;  // Record<string, unknown>
+        x;  // never
 >x : never
     }
     x;  // Record<string, unknown>
 >x : Record<string, unknown>
 }
 
+// Check that {} is a strict supertype of Record<string, any>
+
+declare function isObject3(value: unknown): value is Record<string, any>;
+>isObject3 : (value: unknown) => value is Record<string, any>
+>value : unknown
+
+function gg3(x: {}) {
+>gg3 : (x: {}) => void
+>x : {}
+
+    if (isObject3(x)) {
+>isObject3(x) : boolean
+>isObject3 : (value: unknown) => value is Record<string, any>
+>x : {}
+
+        x;  // Record<string, any>
+>x : Record<string, any>
+    }
+    else {
+        x;  // {}
+>x : {}
+    }
+    x;  // {}
+>x : {}
+}
+
+declare function isObject4(value: unknown): value is {};
+>isObject4 : (value: unknown) => value is {}
+>value : unknown
+
+function gg4(x: Record<string, any>) {
+>gg4 : (x: Record<string, any>) => void
+>x : Record<string, any>
+
+    if (isObject4(x)) {
+>isObject4(x) : boolean
+>isObject4 : (value: unknown) => value is {}
+>x : Record<string, any>
+
+        x;  // Record<string, any>
+>x : Record<string, any>
+    }
+    else {
+        x;  // never
+>x : never
+    }
+    x;  // Record<string, any>
+>x : Record<string, any>
+}
+
 // Repro from #50916
 
 type Identity<T> = {[K in keyof T]: T[K]};
@@ -203,3 +253,127 @@ function example(x: Union) {
 >x : Union
 }
 
+function checksArrayOrObject1(obj: Record<string, any> | Record<string, any>[]) {
+>checksArrayOrObject1 : (obj: Record<string, any> | Record<string, any>[]) => void
+>obj : Record<string, any> | Record<string, any>[]
+
+    // "accidentally" guards the first branch on the length
+    if (Array.isArray(obj) && obj.length) {
+>Array.isArray(obj) && obj.length : number | false
+>Array.isArray(obj) : boolean
+>Array.isArray : (arg: any) => arg is any[]
+>Array : ArrayConstructor
+>isArray : (arg: any) => arg is any[]
+>obj : Record<string, any> | Record<string, any>[]
+>obj.length : number
+>obj : any[] | Record<string, any>[]
+>length : number
+
+        for (let key in obj) {
+>key : string
+>obj : any[] | Record<string, any>[]
+
+            if (obj[key] !== undefined) {
+>obj[key] !== undefined : boolean
+>obj[key] : any
+>obj : any[] | Record<string, any>[]
+>key : string
+>undefined : undefined
+
+                console.log(obj[key])
+>console.log(obj[key]) : void
+>console.log : (...data: any[]) => void
+>console : Console
+>log : (...data: any[]) => void
+>obj[key] : any
+>obj : any[] | Record<string, any>[]
+>key : string
+            }
+        }
+    }
+    else {
+        // 'obj' should probably not include an array type here.
+        for (let key in obj) {
+>key : string
+>obj : any[] | Record<string, any>
+
+            if (obj[key] !== undefined) {
+>obj[key] !== undefined : boolean
+>obj[key] : any
+>obj : any[] | Record<string, any>
+>key : string
+>undefined : undefined
+
+                console.log(obj[key])
+>console.log(obj[key]) : void
+>console.log : (...data: any[]) => void
+>console : Console
+>log : (...data: any[]) => void
+>obj[key] : any
+>obj : any[] | Record<string, any>
+>key : string
+            }
+        }
+    }
+}
+
+function checksArrayOrObject2(obj: Record<string, any> | Record<string, any>[]) {
+>checksArrayOrObject2 : (obj: Record<string, any> | Record<string, any>[]) => void
+>obj : Record<string, any> | Record<string, any>[]
+
+    if (Array.isArray(obj)) {
+>Array.isArray(obj) : boolean
+>Array.isArray : (arg: any) => arg is any[]
+>Array : ArrayConstructor
+>isArray : (arg: any) => arg is any[]
+>obj : Record<string, any> | Record<string, any>[]
+
+        // obj should only be an array type here
+        for (let key in obj) {
+>key : string
+>obj : any[] | Record<string, any>[]
+
+            if (obj[key] !== undefined) {
+>obj[key] !== undefined : boolean
+>obj[key] : any
+>obj : any[] | Record<string, any>[]
+>key : string
+>undefined : undefined
+
+                console.log(obj[key])
+>console.log(obj[key]) : void
+>console.log : (...data: any[]) => void
+>console : Console
+>log : (...data: any[]) => void
+>obj[key] : any
+>obj : any[] | Record<string, any>[]
+>key : string
+            }
+        }
+    }
+    else {
+        // 'obj' should probably not include an array type here.
+        for (let key in obj) {
+>key : string
+>obj : Record<string, any>
+
+            if (obj[key] !== undefined) {
+>obj[key] !== undefined : boolean
+>obj[key] : any
+>obj : Record<string, any>
+>key : string
+>undefined : undefined
+
+                console.log(obj[key])
+>console.log(obj[key]) : void
+>console.log : (...data: any[]) => void
+>console : Console
+>log : (...data: any[]) => void
+>obj[key] : any
+>obj : Record<string, any>
+>key : string
+            }
+        }
+    }
+}
+
diff --git a/tests/cases/compiler/narrowingMutualSubtypes.ts b/tests/cases/compiler/narrowingMutualSubtypes.ts
index 1d666c256fa77..de026cb2066ad 100644
--- a/tests/cases/compiler/narrowingMutualSubtypes.ts
+++ b/tests/cases/compiler/narrowingMutualSubtypes.ts
@@ -28,11 +28,11 @@ const c4 = {};
 const a4a = [c4, r4];  // {}[]
 const a4b = [r4, c4];  // {}[]
 
-// Check that narrowing preserves original type in false branch for non-identical mutual subtypes
+// Check that {} is a strict supertype of Record<string, unknown>
 
 declare function isObject1(value: unknown): value is Record<string, unknown>;
 
-function gg(x: {}) {
+function gg1(x: {}) {
     if (isObject1(x)) {
         x;  // Record<string, unknown>
     }
@@ -46,14 +46,40 @@ declare function isObject2(value: unknown): value is {};
 
 function gg2(x: Record<string, unknown>) {
     if (isObject2(x)) {
-        x;  // {}
+        x;  // Record<string, unknown>
     }
     else {
-        x;  // Record<string, unknown>
+        x;  // never
     }
     x;  // Record<string, unknown>
 }
 
+// Check that {} is a strict supertype of Record<string, any>
+
+declare function isObject3(value: unknown): value is Record<string, any>;
+
+function gg3(x: {}) {
+    if (isObject3(x)) {
+        x;  // Record<string, any>
+    }
+    else {
+        x;  // {}
+    }
+    x;  // {}
+}
+
+declare function isObject4(value: unknown): value is {};
+
+function gg4(x: Record<string, any>) {
+    if (isObject4(x)) {
+        x;  // Record<string, any>
+    }
+    else {
+        x;  // never
+    }
+    x;  // Record<string, any>
+}
+
 // Repro from #50916
 
 type Identity<T> = {[K in keyof T]: T[K]};
@@ -77,3 +103,41 @@ function example(x: Union) {
     if (is(x)) {}
     x;  // Union
 }
+
+function checksArrayOrObject1(obj: Record<string, any> | Record<string, any>[]) {
+    // "accidentally" guards the first branch on the length
+    if (Array.isArray(obj) && obj.length) {
+        for (let key in obj) {
+            if (obj[key] !== undefined) {
+                console.log(obj[key])
+            }
+        }
+    }
+    else {
+        // 'obj' should probably not include an array type here.
+        for (let key in obj) {
+            if (obj[key] !== undefined) {
+                console.log(obj[key])
+            }
+        }
+    }
+}
+
+function checksArrayOrObject2(obj: Record<string, any> | Record<string, any>[]) {
+    if (Array.isArray(obj)) {
+        // obj should only be an array type here
+        for (let key in obj) {
+            if (obj[key] !== undefined) {
+                console.log(obj[key])
+            }
+        }
+    }
+    else {
+        // 'obj' should probably not include an array type here.
+        for (let key in obj) {
+            if (obj[key] !== undefined) {
+                console.log(obj[key])
+            }
+        }
+    }
+}