diff --git a/src/compiler/binder.ts b/src/compiler/binder.ts
index eefc41fdaf8b5..24e8b96d6302c 100644
--- a/src/compiler/binder.ts
+++ b/src/compiler/binder.ts
@@ -1365,7 +1365,7 @@ namespace ts {
         }
 
         function maybeBindExpressionFlowIfCall(node: Expression) {
-            // A top level or LHS of comma expression call expression with a dotted function name and at least one argument
+            // A top level or comma expression call expression with a dotted function name and at least one argument
             // is potentially an assertion and is therefore included in the control flow.
             if (node.kind === SyntaxKind.CallExpression) {
                 const call = node as CallExpression;
@@ -1550,24 +1550,29 @@ namespace ts {
                 return state;
             }
 
-            function onLeft(left: Expression, state: WorkArea, _node: BinaryExpression) {
+            function onLeft(left: Expression, state: WorkArea, node: BinaryExpression) {
                 if (!state.skip) {
-                    return maybeBind(left);
+                    const maybeBound = maybeBind(left);
+                    if (node.operatorToken.kind === SyntaxKind.CommaToken) {
+                        maybeBindExpressionFlowIfCall(left);
+                    }
+                    return maybeBound;
                 }
             }
 
-            function onOperator(operatorToken: BinaryOperatorToken, state: WorkArea, node: BinaryExpression) {
+            function onOperator(operatorToken: BinaryOperatorToken, state: WorkArea, _node: BinaryExpression) {
                 if (!state.skip) {
-                    if (operatorToken.kind === SyntaxKind.CommaToken) {
-                        maybeBindExpressionFlowIfCall(node.left);
-                    }
                     bind(operatorToken);
                 }
             }
 
-            function onRight(right: Expression, state: WorkArea, _node: BinaryExpression) {
+            function onRight(right: Expression, state: WorkArea, node: BinaryExpression) {
                 if (!state.skip) {
-                    return maybeBind(right);
+                    const maybeBound = maybeBind(right);
+                    if (node.operatorToken.kind === SyntaxKind.CommaToken) {
+                        maybeBindExpressionFlowIfCall(right);
+                    }
+                    return maybeBound;
                 }
             }
 
diff --git a/tests/baselines/reference/controlFlowCommaExpressionAssertionMultiple.js b/tests/baselines/reference/controlFlowCommaExpressionAssertionMultiple.js
new file mode 100644
index 0000000000000..0a60d98a46b2c
--- /dev/null
+++ b/tests/baselines/reference/controlFlowCommaExpressionAssertionMultiple.js
@@ -0,0 +1,30 @@
+//// [controlFlowCommaExpressionAssertionMultiple.ts]
+function Narrow<T>(value: any): asserts value is T {}
+
+function func(foo: any, bar: any) {
+    Narrow<number>(foo), Narrow<string>(bar);
+    foo;
+    bar;
+}
+
+function func2(foo: any, bar: any, baz: any) {
+    Narrow<number>(foo), Narrow<string>(bar), Narrow<boolean>(baz);
+    foo;
+    bar;
+    baz;
+}
+
+
+//// [controlFlowCommaExpressionAssertionMultiple.js]
+function Narrow(value) { }
+function func(foo, bar) {
+    Narrow(foo), Narrow(bar);
+    foo;
+    bar;
+}
+function func2(foo, bar, baz) {
+    Narrow(foo), Narrow(bar), Narrow(baz);
+    foo;
+    bar;
+    baz;
+}
diff --git a/tests/baselines/reference/controlFlowCommaExpressionAssertionMultiple.symbols b/tests/baselines/reference/controlFlowCommaExpressionAssertionMultiple.symbols
new file mode 100644
index 0000000000000..d95ac53dd5e8e
--- /dev/null
+++ b/tests/baselines/reference/controlFlowCommaExpressionAssertionMultiple.symbols
@@ -0,0 +1,50 @@
+=== tests/cases/compiler/controlFlowCommaExpressionAssertionMultiple.ts ===
+function Narrow<T>(value: any): asserts value is T {}
+>Narrow : Symbol(Narrow, Decl(controlFlowCommaExpressionAssertionMultiple.ts, 0, 0))
+>T : Symbol(T, Decl(controlFlowCommaExpressionAssertionMultiple.ts, 0, 16))
+>value : Symbol(value, Decl(controlFlowCommaExpressionAssertionMultiple.ts, 0, 19))
+>value : Symbol(value, Decl(controlFlowCommaExpressionAssertionMultiple.ts, 0, 19))
+>T : Symbol(T, Decl(controlFlowCommaExpressionAssertionMultiple.ts, 0, 16))
+
+function func(foo: any, bar: any) {
+>func : Symbol(func, Decl(controlFlowCommaExpressionAssertionMultiple.ts, 0, 53))
+>foo : Symbol(foo, Decl(controlFlowCommaExpressionAssertionMultiple.ts, 2, 14))
+>bar : Symbol(bar, Decl(controlFlowCommaExpressionAssertionMultiple.ts, 2, 23))
+
+    Narrow<number>(foo), Narrow<string>(bar);
+>Narrow : Symbol(Narrow, Decl(controlFlowCommaExpressionAssertionMultiple.ts, 0, 0))
+>foo : Symbol(foo, Decl(controlFlowCommaExpressionAssertionMultiple.ts, 2, 14))
+>Narrow : Symbol(Narrow, Decl(controlFlowCommaExpressionAssertionMultiple.ts, 0, 0))
+>bar : Symbol(bar, Decl(controlFlowCommaExpressionAssertionMultiple.ts, 2, 23))
+
+    foo;
+>foo : Symbol(foo, Decl(controlFlowCommaExpressionAssertionMultiple.ts, 2, 14))
+
+    bar;
+>bar : Symbol(bar, Decl(controlFlowCommaExpressionAssertionMultiple.ts, 2, 23))
+}
+
+function func2(foo: any, bar: any, baz: any) {
+>func2 : Symbol(func2, Decl(controlFlowCommaExpressionAssertionMultiple.ts, 6, 1))
+>foo : Symbol(foo, Decl(controlFlowCommaExpressionAssertionMultiple.ts, 8, 15))
+>bar : Symbol(bar, Decl(controlFlowCommaExpressionAssertionMultiple.ts, 8, 24))
+>baz : Symbol(baz, Decl(controlFlowCommaExpressionAssertionMultiple.ts, 8, 34))
+
+    Narrow<number>(foo), Narrow<string>(bar), Narrow<boolean>(baz);
+>Narrow : Symbol(Narrow, Decl(controlFlowCommaExpressionAssertionMultiple.ts, 0, 0))
+>foo : Symbol(foo, Decl(controlFlowCommaExpressionAssertionMultiple.ts, 8, 15))
+>Narrow : Symbol(Narrow, Decl(controlFlowCommaExpressionAssertionMultiple.ts, 0, 0))
+>bar : Symbol(bar, Decl(controlFlowCommaExpressionAssertionMultiple.ts, 8, 24))
+>Narrow : Symbol(Narrow, Decl(controlFlowCommaExpressionAssertionMultiple.ts, 0, 0))
+>baz : Symbol(baz, Decl(controlFlowCommaExpressionAssertionMultiple.ts, 8, 34))
+
+    foo;
+>foo : Symbol(foo, Decl(controlFlowCommaExpressionAssertionMultiple.ts, 8, 15))
+
+    bar;
+>bar : Symbol(bar, Decl(controlFlowCommaExpressionAssertionMultiple.ts, 8, 24))
+
+    baz;
+>baz : Symbol(baz, Decl(controlFlowCommaExpressionAssertionMultiple.ts, 8, 34))
+}
+
diff --git a/tests/baselines/reference/controlFlowCommaExpressionAssertionMultiple.types b/tests/baselines/reference/controlFlowCommaExpressionAssertionMultiple.types
new file mode 100644
index 0000000000000..8010e69acd79d
--- /dev/null
+++ b/tests/baselines/reference/controlFlowCommaExpressionAssertionMultiple.types
@@ -0,0 +1,55 @@
+=== tests/cases/compiler/controlFlowCommaExpressionAssertionMultiple.ts ===
+function Narrow<T>(value: any): asserts value is T {}
+>Narrow : <T>(value: any) => asserts value is T
+>value : any
+
+function func(foo: any, bar: any) {
+>func : (foo: any, bar: any) => void
+>foo : any
+>bar : any
+
+    Narrow<number>(foo), Narrow<string>(bar);
+>Narrow<number>(foo), Narrow<string>(bar) : void
+>Narrow<number>(foo) : void
+>Narrow : <T>(value: any) => asserts value is T
+>foo : any
+>Narrow<string>(bar) : void
+>Narrow : <T>(value: any) => asserts value is T
+>bar : any
+
+    foo;
+>foo : number
+
+    bar;
+>bar : string
+}
+
+function func2(foo: any, bar: any, baz: any) {
+>func2 : (foo: any, bar: any, baz: any) => void
+>foo : any
+>bar : any
+>baz : any
+
+    Narrow<number>(foo), Narrow<string>(bar), Narrow<boolean>(baz);
+>Narrow<number>(foo), Narrow<string>(bar), Narrow<boolean>(baz) : void
+>Narrow<number>(foo), Narrow<string>(bar) : void
+>Narrow<number>(foo) : void
+>Narrow : <T>(value: any) => asserts value is T
+>foo : any
+>Narrow<string>(bar) : void
+>Narrow : <T>(value: any) => asserts value is T
+>bar : any
+>Narrow<boolean>(baz) : void
+>Narrow : <T>(value: any) => asserts value is T
+>baz : any
+
+    foo;
+>foo : number
+
+    bar;
+>bar : string
+
+    baz;
+>baz : boolean
+}
+
diff --git a/tests/cases/compiler/controlFlowCommaExpressionAssertionMultiple.ts b/tests/cases/compiler/controlFlowCommaExpressionAssertionMultiple.ts
new file mode 100644
index 0000000000000..8e4d1459bcfd6
--- /dev/null
+++ b/tests/cases/compiler/controlFlowCommaExpressionAssertionMultiple.ts
@@ -0,0 +1,14 @@
+function Narrow<T>(value: any): asserts value is T {}
+
+function func(foo: any, bar: any) {
+    Narrow<number>(foo), Narrow<string>(bar);
+    foo;
+    bar;
+}
+
+function func2(foo: any, bar: any, baz: any) {
+    Narrow<number>(foo), Narrow<string>(bar), Narrow<boolean>(baz);
+    foo;
+    bar;
+    baz;
+}