diff --git a/src/compiler/checker.ts b/src/compiler/checker.ts
index e256b43e3b495..4a896d2a70fc2 100644
--- a/src/compiler/checker.ts
+++ b/src/compiler/checker.ts
@@ -20147,6 +20147,12 @@ namespace ts {
                         if (right.kind === SyntaxKind.TypeOfExpression && isStringLiteralLike(left)) {
                             return narrowTypeByTypeof(type, <TypeOfExpression>right, operator, left, assumeTrue);
                         }
+                        if (isConstructorAccessExpression(left)) {
+                            return narrowTypeByConstructor(type, left, operator, right, assumeTrue);
+                        }
+                        if (isConstructorAccessExpression(right)) {
+                            return narrowTypeByConstructor(type, right, operator, left, assumeTrue);
+                        }
                         if (isMatchingReference(reference, left)) {
                             return narrowTypeByEquality(type, operator, right, assumeTrue);
                         }
@@ -20432,6 +20438,59 @@ namespace ts {
                 return getTypeWithFacts(mapType(type, narrowTypeForTypeofSwitch(impliedType)), switchFacts);
             }
 
+            function narrowTypeByConstructor(type: Type, constructorAccessExpr: AccessExpression, operator: SyntaxKind, identifier: Expression, assumeTrue: boolean): Type {
+                // Do not narrow when checking inequality.
+                if (assumeTrue ? (operator !== SyntaxKind.EqualsEqualsToken && operator !== SyntaxKind.EqualsEqualsEqualsToken) : (operator !== SyntaxKind.ExclamationEqualsToken && operator !== SyntaxKind.ExclamationEqualsEqualsToken)) {
+                    return type;
+                }
+
+                // In the case of `x.y`, a `x.constructor === T` type guard resets the narrowed type of `y` to its declared type.
+                if (!isMatchingReference(reference, constructorAccessExpr.expression)) {
+                    return declaredType;
+                }
+
+                // Get the type of the constructor identifier expression, if it is not a function then do not narrow.
+                const identifierType = getTypeOfExpression(identifier);
+                if (!isFunctionType(identifierType) && !isConstructorType(identifierType)) {
+                    return type;
+                }
+
+                // Get the prototype property of the type identifier so we can find out its type.
+                const prototypeProperty = getPropertyOfType(identifierType, "prototype" as __String);
+                if (!prototypeProperty) {
+                    return type;
+                }
+
+                // Get the type of the prototype, if it is undefined, or the global `Object` or `Function` types then do not narrow.
+                const prototypeType = getTypeOfSymbol(prototypeProperty);
+                const candidate = !isTypeAny(prototypeType) ? prototypeType : undefined;
+                if (!candidate || candidate === globalObjectType || candidate === globalFunctionType) {
+                    return type;
+                }
+
+                // If the type that is being narrowed is `any` then just return the `candidate` type since every type is a subtype of `any`.
+                if (isTypeAny(type)) {
+                    return candidate;
+                }
+
+                // Filter out types that are not considered to be "constructed by" the `candidate` type.
+                return filterType(type, t => isConstructedBy(t, candidate));
+
+                function isConstructedBy(source: Type, target: Type) {
+                    // If either the source or target type are a class type then we need to check that they are the same exact type.
+                    // This is because you may have a class `A` that defines some set of properties, and another class `B`
+                    // that defines the same set of properties as class `A`, in that case they are structurally the same
+                    // type, but when you do something like `instanceOfA.constructor === B` it will return false.
+                    if (source.flags & TypeFlags.Object && getObjectFlags(source) & ObjectFlags.Class ||
+                        target.flags & TypeFlags.Object && getObjectFlags(target) & ObjectFlags.Class) {
+                        return source.symbol === target.symbol;
+                    }
+
+                    // For all other types just check that the `source` type is a subtype of the `target` type.
+                    return isTypeSubtypeOf(source, target);
+                }
+            }
+
             function narrowTypeByInstanceof(type: Type, expr: BinaryExpression, assumeTrue: boolean): Type {
                 const left = getReferenceCandidate(expr.left);
                 if (!isMatchingReference(reference, left)) {
diff --git a/src/compiler/utilities.ts b/src/compiler/utilities.ts
index 087e047032e5b..65c2b4d4407bd 100644
--- a/src/compiler/utilities.ts
+++ b/src/compiler/utilities.ts
@@ -4426,6 +4426,13 @@ namespace ts {
         return isPropertyAccessExpression(node) && isEntityNameExpression(node.expression);
     }
 
+    export function isConstructorAccessExpression(expr: Expression): expr is AccessExpression {
+        return (
+            isPropertyAccessExpression(expr) && idText(expr.name) === "constructor" ||
+            isElementAccessExpression(expr) && isStringLiteralLike(expr.argumentExpression) && expr.argumentExpression.text === "constructor"
+        );
+    }
+
     export function tryGetPropertyAccessOrIdentifierToString(expr: Expression): string | undefined {
         if (isPropertyAccessExpression(expr)) {
             const baseStr = tryGetPropertyAccessOrIdentifierToString(expr.expression);
diff --git a/tests/baselines/reference/typeGuardConstructorClassAndNumber.errors.txt b/tests/baselines/reference/typeGuardConstructorClassAndNumber.errors.txt
new file mode 100644
index 0000000000000..b356fddd14ef4
--- /dev/null
+++ b/tests/baselines/reference/typeGuardConstructorClassAndNumber.errors.txt
@@ -0,0 +1,163 @@
+tests/cases/compiler/typeGuardConstructorClassAndNumber.ts(66,10): error TS2339: Property 'property1' does not exist on type 'number | C1'.
+  Property 'property1' does not exist on type 'number'.
+tests/cases/compiler/typeGuardConstructorClassAndNumber.ts(73,10): error TS2339: Property 'property1' does not exist on type 'number | C1'.
+  Property 'property1' does not exist on type 'number'.
+tests/cases/compiler/typeGuardConstructorClassAndNumber.ts(80,10): error TS2339: Property 'property1' does not exist on type 'number | C1'.
+  Property 'property1' does not exist on type 'number'.
+tests/cases/compiler/typeGuardConstructorClassAndNumber.ts(87,10): error TS2339: Property 'property1' does not exist on type 'number | C1'.
+  Property 'property1' does not exist on type 'number'.
+tests/cases/compiler/typeGuardConstructorClassAndNumber.ts(94,10): error TS2339: Property 'property1' does not exist on type 'number | C1'.
+  Property 'property1' does not exist on type 'number'.
+tests/cases/compiler/typeGuardConstructorClassAndNumber.ts(101,10): error TS2339: Property 'property1' does not exist on type 'number | C1'.
+  Property 'property1' does not exist on type 'number'.
+tests/cases/compiler/typeGuardConstructorClassAndNumber.ts(108,10): error TS2339: Property 'property1' does not exist on type 'number | C1'.
+  Property 'property1' does not exist on type 'number'.
+tests/cases/compiler/typeGuardConstructorClassAndNumber.ts(115,10): error TS2339: Property 'property1' does not exist on type 'number | C1'.
+  Property 'property1' does not exist on type 'number'.
+
+
+==== tests/cases/compiler/typeGuardConstructorClassAndNumber.ts (8 errors) ====
+    // Typical case
+    class C1 {
+        property1: string;
+    }
+    
+    let var1: C1 | number;
+    if (var1.constructor == C1) {
+        var1; // C1
+        var1.property1; // string
+    }
+    else {
+        var1; // number | C1
+    }
+    if (var1["constructor"] == C1) {
+        var1; // C1
+        var1.property1; // string
+    }
+    else {
+        var1; // number | C1
+    }
+    if (var1.constructor === C1) {
+        var1; // C1
+        var1.property1; // string
+    }
+    else {
+        var1; // number | C1
+    }
+    if (var1["constructor"] === C1) {
+        var1; // C1
+        var1.property1; // string
+    }
+    else {
+        var1; // number | C1
+    }
+    if (C1 == var1.constructor) {
+        var1; // C1
+        var1.property1; // string
+    }
+    else {
+        var1; // number | C1
+    }
+    if (C1 == var1["constructor"]) {
+        var1; // C1
+        var1.property1; // string
+    }
+    else {
+        var1; // number | C1
+    }
+    if (C1 === var1.constructor) {
+        var1; // C1
+        var1.property1; // string
+    }
+    else {
+        var1; // number | C1
+    }
+    if (C1 === var1["constructor"]) {
+        var1; // C1
+        var1.property1; // string
+    }
+    else {
+        var1; // number | C1
+    }
+    
+    if (var1.constructor != C1) {
+        var1; // C1 | number
+        var1.property1; // error
+             ~~~~~~~~~
+!!! error TS2339: Property 'property1' does not exist on type 'number | C1'.
+!!! error TS2339:   Property 'property1' does not exist on type 'number'.
+    }
+    else {
+        var1; // C1
+    }
+    if (var1["constructor"] != C1) {
+        var1; // C1 | number
+        var1.property1; // error
+             ~~~~~~~~~
+!!! error TS2339: Property 'property1' does not exist on type 'number | C1'.
+!!! error TS2339:   Property 'property1' does not exist on type 'number'.
+    }
+    else {
+        var1; // C1
+    }
+    if (var1.constructor !== C1) {
+        var1; // C1 | number
+        var1.property1; // error
+             ~~~~~~~~~
+!!! error TS2339: Property 'property1' does not exist on type 'number | C1'.
+!!! error TS2339:   Property 'property1' does not exist on type 'number'.
+    }
+    else {
+        var1; // C1
+    }
+    if (var1["constructor"] !== C1) {
+        var1; // C1 | number
+        var1.property1; // error
+             ~~~~~~~~~
+!!! error TS2339: Property 'property1' does not exist on type 'number | C1'.
+!!! error TS2339:   Property 'property1' does not exist on type 'number'.
+    }
+    else {
+        var1; // C1
+    }
+    if (C1 != var1.constructor) {
+        var1; // C1 | number
+        var1.property1; // error
+             ~~~~~~~~~
+!!! error TS2339: Property 'property1' does not exist on type 'number | C1'.
+!!! error TS2339:   Property 'property1' does not exist on type 'number'.
+    }
+    else {
+        var1; // C1
+    }
+    if (C1 != var1["constructor"]) {
+        var1; // C1 | number
+        var1.property1; // error
+             ~~~~~~~~~
+!!! error TS2339: Property 'property1' does not exist on type 'number | C1'.
+!!! error TS2339:   Property 'property1' does not exist on type 'number'.
+    }
+    else {
+        var1; // C1
+    }
+    if (C1 !== var1.constructor) {
+        var1; // C1 | number
+        var1.property1; // error
+             ~~~~~~~~~
+!!! error TS2339: Property 'property1' does not exist on type 'number | C1'.
+!!! error TS2339:   Property 'property1' does not exist on type 'number'.
+    }
+    else {
+        var1; // C1
+    }
+    if (C1 !== var1["constructor"]) {
+        var1; // C1 | number
+        var1.property1; // error
+             ~~~~~~~~~
+!!! error TS2339: Property 'property1' does not exist on type 'number | C1'.
+!!! error TS2339:   Property 'property1' does not exist on type 'number'.
+    }
+    else {
+        var1; // C1
+    }
+    
\ No newline at end of file
diff --git a/tests/baselines/reference/typeGuardConstructorClassAndNumber.js b/tests/baselines/reference/typeGuardConstructorClassAndNumber.js
new file mode 100644
index 0000000000000..188de4cf06733
--- /dev/null
+++ b/tests/baselines/reference/typeGuardConstructorClassAndNumber.js
@@ -0,0 +1,242 @@
+//// [typeGuardConstructorClassAndNumber.ts]
+// Typical case
+class C1 {
+    property1: string;
+}
+
+let var1: C1 | number;
+if (var1.constructor == C1) {
+    var1; // C1
+    var1.property1; // string
+}
+else {
+    var1; // number | C1
+}
+if (var1["constructor"] == C1) {
+    var1; // C1
+    var1.property1; // string
+}
+else {
+    var1; // number | C1
+}
+if (var1.constructor === C1) {
+    var1; // C1
+    var1.property1; // string
+}
+else {
+    var1; // number | C1
+}
+if (var1["constructor"] === C1) {
+    var1; // C1
+    var1.property1; // string
+}
+else {
+    var1; // number | C1
+}
+if (C1 == var1.constructor) {
+    var1; // C1
+    var1.property1; // string
+}
+else {
+    var1; // number | C1
+}
+if (C1 == var1["constructor"]) {
+    var1; // C1
+    var1.property1; // string
+}
+else {
+    var1; // number | C1
+}
+if (C1 === var1.constructor) {
+    var1; // C1
+    var1.property1; // string
+}
+else {
+    var1; // number | C1
+}
+if (C1 === var1["constructor"]) {
+    var1; // C1
+    var1.property1; // string
+}
+else {
+    var1; // number | C1
+}
+
+if (var1.constructor != C1) {
+    var1; // C1 | number
+    var1.property1; // error
+}
+else {
+    var1; // C1
+}
+if (var1["constructor"] != C1) {
+    var1; // C1 | number
+    var1.property1; // error
+}
+else {
+    var1; // C1
+}
+if (var1.constructor !== C1) {
+    var1; // C1 | number
+    var1.property1; // error
+}
+else {
+    var1; // C1
+}
+if (var1["constructor"] !== C1) {
+    var1; // C1 | number
+    var1.property1; // error
+}
+else {
+    var1; // C1
+}
+if (C1 != var1.constructor) {
+    var1; // C1 | number
+    var1.property1; // error
+}
+else {
+    var1; // C1
+}
+if (C1 != var1["constructor"]) {
+    var1; // C1 | number
+    var1.property1; // error
+}
+else {
+    var1; // C1
+}
+if (C1 !== var1.constructor) {
+    var1; // C1 | number
+    var1.property1; // error
+}
+else {
+    var1; // C1
+}
+if (C1 !== var1["constructor"]) {
+    var1; // C1 | number
+    var1.property1; // error
+}
+else {
+    var1; // C1
+}
+
+
+//// [typeGuardConstructorClassAndNumber.js]
+// Typical case
+var C1 = /** @class */ (function () {
+    function C1() {
+    }
+    return C1;
+}());
+var var1;
+if (var1.constructor == C1) {
+    var1; // C1
+    var1.property1; // string
+}
+else {
+    var1; // number | C1
+}
+if (var1["constructor"] == C1) {
+    var1; // C1
+    var1.property1; // string
+}
+else {
+    var1; // number | C1
+}
+if (var1.constructor === C1) {
+    var1; // C1
+    var1.property1; // string
+}
+else {
+    var1; // number | C1
+}
+if (var1["constructor"] === C1) {
+    var1; // C1
+    var1.property1; // string
+}
+else {
+    var1; // number | C1
+}
+if (C1 == var1.constructor) {
+    var1; // C1
+    var1.property1; // string
+}
+else {
+    var1; // number | C1
+}
+if (C1 == var1["constructor"]) {
+    var1; // C1
+    var1.property1; // string
+}
+else {
+    var1; // number | C1
+}
+if (C1 === var1.constructor) {
+    var1; // C1
+    var1.property1; // string
+}
+else {
+    var1; // number | C1
+}
+if (C1 === var1["constructor"]) {
+    var1; // C1
+    var1.property1; // string
+}
+else {
+    var1; // number | C1
+}
+if (var1.constructor != C1) {
+    var1; // C1 | number
+    var1.property1; // error
+}
+else {
+    var1; // C1
+}
+if (var1["constructor"] != C1) {
+    var1; // C1 | number
+    var1.property1; // error
+}
+else {
+    var1; // C1
+}
+if (var1.constructor !== C1) {
+    var1; // C1 | number
+    var1.property1; // error
+}
+else {
+    var1; // C1
+}
+if (var1["constructor"] !== C1) {
+    var1; // C1 | number
+    var1.property1; // error
+}
+else {
+    var1; // C1
+}
+if (C1 != var1.constructor) {
+    var1; // C1 | number
+    var1.property1; // error
+}
+else {
+    var1; // C1
+}
+if (C1 != var1["constructor"]) {
+    var1; // C1 | number
+    var1.property1; // error
+}
+else {
+    var1; // C1
+}
+if (C1 !== var1.constructor) {
+    var1; // C1 | number
+    var1.property1; // error
+}
+else {
+    var1; // C1
+}
+if (C1 !== var1["constructor"]) {
+    var1; // C1 | number
+    var1.property1; // error
+}
+else {
+    var1; // C1
+}
diff --git a/tests/baselines/reference/typeGuardConstructorClassAndNumber.symbols b/tests/baselines/reference/typeGuardConstructorClassAndNumber.symbols
new file mode 100644
index 0000000000000..893ad03fad252
--- /dev/null
+++ b/tests/baselines/reference/typeGuardConstructorClassAndNumber.symbols
@@ -0,0 +1,279 @@
+=== tests/cases/compiler/typeGuardConstructorClassAndNumber.ts ===
+// Typical case
+class C1 {
+>C1 : Symbol(C1, Decl(typeGuardConstructorClassAndNumber.ts, 0, 0))
+
+    property1: string;
+>property1 : Symbol(C1.property1, Decl(typeGuardConstructorClassAndNumber.ts, 1, 10))
+}
+
+let var1: C1 | number;
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+>C1 : Symbol(C1, Decl(typeGuardConstructorClassAndNumber.ts, 0, 0))
+
+if (var1.constructor == C1) {
+>var1.constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+>constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>C1 : Symbol(C1, Decl(typeGuardConstructorClassAndNumber.ts, 0, 0))
+
+    var1; // C1
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+
+    var1.property1; // string
+>var1.property1 : Symbol(C1.property1, Decl(typeGuardConstructorClassAndNumber.ts, 1, 10))
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+>property1 : Symbol(C1.property1, Decl(typeGuardConstructorClassAndNumber.ts, 1, 10))
+}
+else {
+    var1; // number | C1
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+}
+if (var1["constructor"] == C1) {
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+>"constructor" : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>C1 : Symbol(C1, Decl(typeGuardConstructorClassAndNumber.ts, 0, 0))
+
+    var1; // C1
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+
+    var1.property1; // string
+>var1.property1 : Symbol(C1.property1, Decl(typeGuardConstructorClassAndNumber.ts, 1, 10))
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+>property1 : Symbol(C1.property1, Decl(typeGuardConstructorClassAndNumber.ts, 1, 10))
+}
+else {
+    var1; // number | C1
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+}
+if (var1.constructor === C1) {
+>var1.constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+>constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>C1 : Symbol(C1, Decl(typeGuardConstructorClassAndNumber.ts, 0, 0))
+
+    var1; // C1
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+
+    var1.property1; // string
+>var1.property1 : Symbol(C1.property1, Decl(typeGuardConstructorClassAndNumber.ts, 1, 10))
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+>property1 : Symbol(C1.property1, Decl(typeGuardConstructorClassAndNumber.ts, 1, 10))
+}
+else {
+    var1; // number | C1
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+}
+if (var1["constructor"] === C1) {
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+>"constructor" : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>C1 : Symbol(C1, Decl(typeGuardConstructorClassAndNumber.ts, 0, 0))
+
+    var1; // C1
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+
+    var1.property1; // string
+>var1.property1 : Symbol(C1.property1, Decl(typeGuardConstructorClassAndNumber.ts, 1, 10))
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+>property1 : Symbol(C1.property1, Decl(typeGuardConstructorClassAndNumber.ts, 1, 10))
+}
+else {
+    var1; // number | C1
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+}
+if (C1 == var1.constructor) {
+>C1 : Symbol(C1, Decl(typeGuardConstructorClassAndNumber.ts, 0, 0))
+>var1.constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+>constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+
+    var1; // C1
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+
+    var1.property1; // string
+>var1.property1 : Symbol(C1.property1, Decl(typeGuardConstructorClassAndNumber.ts, 1, 10))
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+>property1 : Symbol(C1.property1, Decl(typeGuardConstructorClassAndNumber.ts, 1, 10))
+}
+else {
+    var1; // number | C1
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+}
+if (C1 == var1["constructor"]) {
+>C1 : Symbol(C1, Decl(typeGuardConstructorClassAndNumber.ts, 0, 0))
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+>"constructor" : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+
+    var1; // C1
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+
+    var1.property1; // string
+>var1.property1 : Symbol(C1.property1, Decl(typeGuardConstructorClassAndNumber.ts, 1, 10))
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+>property1 : Symbol(C1.property1, Decl(typeGuardConstructorClassAndNumber.ts, 1, 10))
+}
+else {
+    var1; // number | C1
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+}
+if (C1 === var1.constructor) {
+>C1 : Symbol(C1, Decl(typeGuardConstructorClassAndNumber.ts, 0, 0))
+>var1.constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+>constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+
+    var1; // C1
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+
+    var1.property1; // string
+>var1.property1 : Symbol(C1.property1, Decl(typeGuardConstructorClassAndNumber.ts, 1, 10))
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+>property1 : Symbol(C1.property1, Decl(typeGuardConstructorClassAndNumber.ts, 1, 10))
+}
+else {
+    var1; // number | C1
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+}
+if (C1 === var1["constructor"]) {
+>C1 : Symbol(C1, Decl(typeGuardConstructorClassAndNumber.ts, 0, 0))
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+>"constructor" : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+
+    var1; // C1
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+
+    var1.property1; // string
+>var1.property1 : Symbol(C1.property1, Decl(typeGuardConstructorClassAndNumber.ts, 1, 10))
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+>property1 : Symbol(C1.property1, Decl(typeGuardConstructorClassAndNumber.ts, 1, 10))
+}
+else {
+    var1; // number | C1
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+}
+
+if (var1.constructor != C1) {
+>var1.constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+>constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>C1 : Symbol(C1, Decl(typeGuardConstructorClassAndNumber.ts, 0, 0))
+
+    var1; // C1 | number
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+
+    var1.property1; // error
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+}
+else {
+    var1; // C1
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+}
+if (var1["constructor"] != C1) {
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+>"constructor" : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>C1 : Symbol(C1, Decl(typeGuardConstructorClassAndNumber.ts, 0, 0))
+
+    var1; // C1 | number
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+
+    var1.property1; // error
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+}
+else {
+    var1; // C1
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+}
+if (var1.constructor !== C1) {
+>var1.constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+>constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>C1 : Symbol(C1, Decl(typeGuardConstructorClassAndNumber.ts, 0, 0))
+
+    var1; // C1 | number
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+
+    var1.property1; // error
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+}
+else {
+    var1; // C1
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+}
+if (var1["constructor"] !== C1) {
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+>"constructor" : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>C1 : Symbol(C1, Decl(typeGuardConstructorClassAndNumber.ts, 0, 0))
+
+    var1; // C1 | number
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+
+    var1.property1; // error
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+}
+else {
+    var1; // C1
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+}
+if (C1 != var1.constructor) {
+>C1 : Symbol(C1, Decl(typeGuardConstructorClassAndNumber.ts, 0, 0))
+>var1.constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+>constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+
+    var1; // C1 | number
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+
+    var1.property1; // error
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+}
+else {
+    var1; // C1
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+}
+if (C1 != var1["constructor"]) {
+>C1 : Symbol(C1, Decl(typeGuardConstructorClassAndNumber.ts, 0, 0))
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+>"constructor" : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+
+    var1; // C1 | number
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+
+    var1.property1; // error
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+}
+else {
+    var1; // C1
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+}
+if (C1 !== var1.constructor) {
+>C1 : Symbol(C1, Decl(typeGuardConstructorClassAndNumber.ts, 0, 0))
+>var1.constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+>constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+
+    var1; // C1 | number
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+
+    var1.property1; // error
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+}
+else {
+    var1; // C1
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+}
+if (C1 !== var1["constructor"]) {
+>C1 : Symbol(C1, Decl(typeGuardConstructorClassAndNumber.ts, 0, 0))
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+>"constructor" : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+
+    var1; // C1 | number
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+
+    var1.property1; // error
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+}
+else {
+    var1; // C1
+>var1 : Symbol(var1, Decl(typeGuardConstructorClassAndNumber.ts, 5, 3))
+}
+
diff --git a/tests/baselines/reference/typeGuardConstructorClassAndNumber.types b/tests/baselines/reference/typeGuardConstructorClassAndNumber.types
new file mode 100644
index 0000000000000..1c4c2fb523091
--- /dev/null
+++ b/tests/baselines/reference/typeGuardConstructorClassAndNumber.types
@@ -0,0 +1,318 @@
+=== tests/cases/compiler/typeGuardConstructorClassAndNumber.ts ===
+// Typical case
+class C1 {
+>C1 : C1
+
+    property1: string;
+>property1 : string
+}
+
+let var1: C1 | number;
+>var1 : number | C1
+
+if (var1.constructor == C1) {
+>var1.constructor == C1 : boolean
+>var1.constructor : Function
+>var1 : number | C1
+>constructor : Function
+>C1 : typeof C1
+
+    var1; // C1
+>var1 : C1
+
+    var1.property1; // string
+>var1.property1 : string
+>var1 : C1
+>property1 : string
+}
+else {
+    var1; // number | C1
+>var1 : number | C1
+}
+if (var1["constructor"] == C1) {
+>var1["constructor"] == C1 : boolean
+>var1["constructor"] : Function
+>var1 : number | C1
+>"constructor" : "constructor"
+>C1 : typeof C1
+
+    var1; // C1
+>var1 : C1
+
+    var1.property1; // string
+>var1.property1 : string
+>var1 : C1
+>property1 : string
+}
+else {
+    var1; // number | C1
+>var1 : number | C1
+}
+if (var1.constructor === C1) {
+>var1.constructor === C1 : boolean
+>var1.constructor : Function
+>var1 : number | C1
+>constructor : Function
+>C1 : typeof C1
+
+    var1; // C1
+>var1 : C1
+
+    var1.property1; // string
+>var1.property1 : string
+>var1 : C1
+>property1 : string
+}
+else {
+    var1; // number | C1
+>var1 : number | C1
+}
+if (var1["constructor"] === C1) {
+>var1["constructor"] === C1 : boolean
+>var1["constructor"] : Function
+>var1 : number | C1
+>"constructor" : "constructor"
+>C1 : typeof C1
+
+    var1; // C1
+>var1 : C1
+
+    var1.property1; // string
+>var1.property1 : string
+>var1 : C1
+>property1 : string
+}
+else {
+    var1; // number | C1
+>var1 : number | C1
+}
+if (C1 == var1.constructor) {
+>C1 == var1.constructor : boolean
+>C1 : typeof C1
+>var1.constructor : Function
+>var1 : number | C1
+>constructor : Function
+
+    var1; // C1
+>var1 : C1
+
+    var1.property1; // string
+>var1.property1 : string
+>var1 : C1
+>property1 : string
+}
+else {
+    var1; // number | C1
+>var1 : number | C1
+}
+if (C1 == var1["constructor"]) {
+>C1 == var1["constructor"] : boolean
+>C1 : typeof C1
+>var1["constructor"] : Function
+>var1 : number | C1
+>"constructor" : "constructor"
+
+    var1; // C1
+>var1 : C1
+
+    var1.property1; // string
+>var1.property1 : string
+>var1 : C1
+>property1 : string
+}
+else {
+    var1; // number | C1
+>var1 : number | C1
+}
+if (C1 === var1.constructor) {
+>C1 === var1.constructor : boolean
+>C1 : typeof C1
+>var1.constructor : Function
+>var1 : number | C1
+>constructor : Function
+
+    var1; // C1
+>var1 : C1
+
+    var1.property1; // string
+>var1.property1 : string
+>var1 : C1
+>property1 : string
+}
+else {
+    var1; // number | C1
+>var1 : number | C1
+}
+if (C1 === var1["constructor"]) {
+>C1 === var1["constructor"] : boolean
+>C1 : typeof C1
+>var1["constructor"] : Function
+>var1 : number | C1
+>"constructor" : "constructor"
+
+    var1; // C1
+>var1 : C1
+
+    var1.property1; // string
+>var1.property1 : string
+>var1 : C1
+>property1 : string
+}
+else {
+    var1; // number | C1
+>var1 : number | C1
+}
+
+if (var1.constructor != C1) {
+>var1.constructor != C1 : boolean
+>var1.constructor : Function
+>var1 : number | C1
+>constructor : Function
+>C1 : typeof C1
+
+    var1; // C1 | number
+>var1 : number | C1
+
+    var1.property1; // error
+>var1.property1 : any
+>var1 : number | C1
+>property1 : any
+}
+else {
+    var1; // C1
+>var1 : C1
+}
+if (var1["constructor"] != C1) {
+>var1["constructor"] != C1 : boolean
+>var1["constructor"] : Function
+>var1 : number | C1
+>"constructor" : "constructor"
+>C1 : typeof C1
+
+    var1; // C1 | number
+>var1 : number | C1
+
+    var1.property1; // error
+>var1.property1 : any
+>var1 : number | C1
+>property1 : any
+}
+else {
+    var1; // C1
+>var1 : C1
+}
+if (var1.constructor !== C1) {
+>var1.constructor !== C1 : boolean
+>var1.constructor : Function
+>var1 : number | C1
+>constructor : Function
+>C1 : typeof C1
+
+    var1; // C1 | number
+>var1 : number | C1
+
+    var1.property1; // error
+>var1.property1 : any
+>var1 : number | C1
+>property1 : any
+}
+else {
+    var1; // C1
+>var1 : C1
+}
+if (var1["constructor"] !== C1) {
+>var1["constructor"] !== C1 : boolean
+>var1["constructor"] : Function
+>var1 : number | C1
+>"constructor" : "constructor"
+>C1 : typeof C1
+
+    var1; // C1 | number
+>var1 : number | C1
+
+    var1.property1; // error
+>var1.property1 : any
+>var1 : number | C1
+>property1 : any
+}
+else {
+    var1; // C1
+>var1 : C1
+}
+if (C1 != var1.constructor) {
+>C1 != var1.constructor : boolean
+>C1 : typeof C1
+>var1.constructor : Function
+>var1 : number | C1
+>constructor : Function
+
+    var1; // C1 | number
+>var1 : number | C1
+
+    var1.property1; // error
+>var1.property1 : any
+>var1 : number | C1
+>property1 : any
+}
+else {
+    var1; // C1
+>var1 : C1
+}
+if (C1 != var1["constructor"]) {
+>C1 != var1["constructor"] : boolean
+>C1 : typeof C1
+>var1["constructor"] : Function
+>var1 : number | C1
+>"constructor" : "constructor"
+
+    var1; // C1 | number
+>var1 : number | C1
+
+    var1.property1; // error
+>var1.property1 : any
+>var1 : number | C1
+>property1 : any
+}
+else {
+    var1; // C1
+>var1 : C1
+}
+if (C1 !== var1.constructor) {
+>C1 !== var1.constructor : boolean
+>C1 : typeof C1
+>var1.constructor : Function
+>var1 : number | C1
+>constructor : Function
+
+    var1; // C1 | number
+>var1 : number | C1
+
+    var1.property1; // error
+>var1.property1 : any
+>var1 : number | C1
+>property1 : any
+}
+else {
+    var1; // C1
+>var1 : C1
+}
+if (C1 !== var1["constructor"]) {
+>C1 !== var1["constructor"] : boolean
+>C1 : typeof C1
+>var1["constructor"] : Function
+>var1 : number | C1
+>"constructor" : "constructor"
+
+    var1; // C1 | number
+>var1 : number | C1
+
+    var1.property1; // error
+>var1.property1 : any
+>var1 : number | C1
+>property1 : any
+}
+else {
+    var1; // C1
+>var1 : C1
+}
+
diff --git a/tests/baselines/reference/typeGuardConstructorDerivedClass.errors.txt b/tests/baselines/reference/typeGuardConstructorDerivedClass.errors.txt
new file mode 100644
index 0000000000000..c0c9e3d88a402
--- /dev/null
+++ b/tests/baselines/reference/typeGuardConstructorDerivedClass.errors.txt
@@ -0,0 +1,72 @@
+tests/cases/compiler/typeGuardConstructorDerivedClass.ts(13,10): error TS2339: Property 'property1' does not exist on type 'never'.
+
+
+==== tests/cases/compiler/typeGuardConstructorDerivedClass.ts (1 errors) ====
+    // Derived class with different structures
+    class C1 {
+        property1: number;
+    }
+    
+    class C2 extends C1 {
+        property2: number;
+    }
+    
+    let var1: C2 | string;
+    if (var1.constructor === C1) {
+        var1; // never
+        var1.property1; // error
+             ~~~~~~~~~
+!!! error TS2339: Property 'property1' does not exist on type 'never'.
+    }
+    if (var1.constructor === C2) {
+        var1; // C2
+        var1.property1; // number
+    }
+    
+    // Derived classes with the same structure
+    class C3 {}
+    
+    class C4 extends C3 {}
+    
+    let var2: C4 | string;
+    if (var2.constructor === C3) {
+        var2; // never
+    }
+    if (var2.constructor === C4) {
+        var2; // C4
+    }
+    
+    // Disjointly structured classes
+    class C5 {
+        property1: number;
+    }
+    
+    class C6 {
+        property2: number;
+    }
+    
+    let let3: C6 | string;
+    if (let3.constructor === C5) {
+        let3; // never
+    }
+    if (let3.constructor === C6) {
+        let3; // C6
+    }
+    
+    // Classes with the same structure
+    class C7 {
+        property1: number
+    }
+    
+    class C8 {
+        property1: number;
+    }
+    
+    let let4: C8 | string;
+    if (let4.constructor === C7) {
+        let4; // never
+    }
+    if (let4.constructor === C8) {
+        let4; // C8
+    }
+    
\ No newline at end of file
diff --git a/tests/baselines/reference/typeGuardConstructorDerivedClass.js b/tests/baselines/reference/typeGuardConstructorDerivedClass.js
new file mode 100644
index 0000000000000..8ffabcb987a90
--- /dev/null
+++ b/tests/baselines/reference/typeGuardConstructorDerivedClass.js
@@ -0,0 +1,160 @@
+//// [typeGuardConstructorDerivedClass.ts]
+// Derived class with different structures
+class C1 {
+    property1: number;
+}
+
+class C2 extends C1 {
+    property2: number;
+}
+
+let var1: C2 | string;
+if (var1.constructor === C1) {
+    var1; // never
+    var1.property1; // error
+}
+if (var1.constructor === C2) {
+    var1; // C2
+    var1.property1; // number
+}
+
+// Derived classes with the same structure
+class C3 {}
+
+class C4 extends C3 {}
+
+let var2: C4 | string;
+if (var2.constructor === C3) {
+    var2; // never
+}
+if (var2.constructor === C4) {
+    var2; // C4
+}
+
+// Disjointly structured classes
+class C5 {
+    property1: number;
+}
+
+class C6 {
+    property2: number;
+}
+
+let let3: C6 | string;
+if (let3.constructor === C5) {
+    let3; // never
+}
+if (let3.constructor === C6) {
+    let3; // C6
+}
+
+// Classes with the same structure
+class C7 {
+    property1: number
+}
+
+class C8 {
+    property1: number;
+}
+
+let let4: C8 | string;
+if (let4.constructor === C7) {
+    let4; // never
+}
+if (let4.constructor === C8) {
+    let4; // C8
+}
+
+
+//// [typeGuardConstructorDerivedClass.js]
+var __extends = (this && this.__extends) || (function () {
+    var extendStatics = function (d, b) {
+        extendStatics = Object.setPrototypeOf ||
+            ({ __proto__: [] } instanceof Array && function (d, b) { d.__proto__ = b; }) ||
+            function (d, b) { for (var p in b) if (b.hasOwnProperty(p)) d[p] = b[p]; };
+        return extendStatics(d, b);
+    };
+    return function (d, b) {
+        extendStatics(d, b);
+        function __() { this.constructor = d; }
+        d.prototype = b === null ? Object.create(b) : (__.prototype = b.prototype, new __());
+    };
+})();
+// Derived class with different structures
+var C1 = /** @class */ (function () {
+    function C1() {
+    }
+    return C1;
+}());
+var C2 = /** @class */ (function (_super) {
+    __extends(C2, _super);
+    function C2() {
+        return _super !== null && _super.apply(this, arguments) || this;
+    }
+    return C2;
+}(C1));
+var var1;
+if (var1.constructor === C1) {
+    var1; // never
+    var1.property1; // error
+}
+if (var1.constructor === C2) {
+    var1; // C2
+    var1.property1; // number
+}
+// Derived classes with the same structure
+var C3 = /** @class */ (function () {
+    function C3() {
+    }
+    return C3;
+}());
+var C4 = /** @class */ (function (_super) {
+    __extends(C4, _super);
+    function C4() {
+        return _super !== null && _super.apply(this, arguments) || this;
+    }
+    return C4;
+}(C3));
+var var2;
+if (var2.constructor === C3) {
+    var2; // never
+}
+if (var2.constructor === C4) {
+    var2; // C4
+}
+// Disjointly structured classes
+var C5 = /** @class */ (function () {
+    function C5() {
+    }
+    return C5;
+}());
+var C6 = /** @class */ (function () {
+    function C6() {
+    }
+    return C6;
+}());
+var let3;
+if (let3.constructor === C5) {
+    let3; // never
+}
+if (let3.constructor === C6) {
+    let3; // C6
+}
+// Classes with the same structure
+var C7 = /** @class */ (function () {
+    function C7() {
+    }
+    return C7;
+}());
+var C8 = /** @class */ (function () {
+    function C8() {
+    }
+    return C8;
+}());
+var let4;
+if (let4.constructor === C7) {
+    let4; // never
+}
+if (let4.constructor === C8) {
+    let4; // C8
+}
diff --git a/tests/baselines/reference/typeGuardConstructorDerivedClass.symbols b/tests/baselines/reference/typeGuardConstructorDerivedClass.symbols
new file mode 100644
index 0000000000000..acb2e8890a2f9
--- /dev/null
+++ b/tests/baselines/reference/typeGuardConstructorDerivedClass.symbols
@@ -0,0 +1,155 @@
+=== tests/cases/compiler/typeGuardConstructorDerivedClass.ts ===
+// Derived class with different structures
+class C1 {
+>C1 : Symbol(C1, Decl(typeGuardConstructorDerivedClass.ts, 0, 0))
+
+    property1: number;
+>property1 : Symbol(C1.property1, Decl(typeGuardConstructorDerivedClass.ts, 1, 10))
+}
+
+class C2 extends C1 {
+>C2 : Symbol(C2, Decl(typeGuardConstructorDerivedClass.ts, 3, 1))
+>C1 : Symbol(C1, Decl(typeGuardConstructorDerivedClass.ts, 0, 0))
+
+    property2: number;
+>property2 : Symbol(C2.property2, Decl(typeGuardConstructorDerivedClass.ts, 5, 21))
+}
+
+let var1: C2 | string;
+>var1 : Symbol(var1, Decl(typeGuardConstructorDerivedClass.ts, 9, 3))
+>C2 : Symbol(C2, Decl(typeGuardConstructorDerivedClass.ts, 3, 1))
+
+if (var1.constructor === C1) {
+>var1.constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>var1 : Symbol(var1, Decl(typeGuardConstructorDerivedClass.ts, 9, 3))
+>constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>C1 : Symbol(C1, Decl(typeGuardConstructorDerivedClass.ts, 0, 0))
+
+    var1; // never
+>var1 : Symbol(var1, Decl(typeGuardConstructorDerivedClass.ts, 9, 3))
+
+    var1.property1; // error
+>var1 : Symbol(var1, Decl(typeGuardConstructorDerivedClass.ts, 9, 3))
+}
+if (var1.constructor === C2) {
+>var1.constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>var1 : Symbol(var1, Decl(typeGuardConstructorDerivedClass.ts, 9, 3))
+>constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>C2 : Symbol(C2, Decl(typeGuardConstructorDerivedClass.ts, 3, 1))
+
+    var1; // C2
+>var1 : Symbol(var1, Decl(typeGuardConstructorDerivedClass.ts, 9, 3))
+
+    var1.property1; // number
+>var1.property1 : Symbol(C1.property1, Decl(typeGuardConstructorDerivedClass.ts, 1, 10))
+>var1 : Symbol(var1, Decl(typeGuardConstructorDerivedClass.ts, 9, 3))
+>property1 : Symbol(C1.property1, Decl(typeGuardConstructorDerivedClass.ts, 1, 10))
+}
+
+// Derived classes with the same structure
+class C3 {}
+>C3 : Symbol(C3, Decl(typeGuardConstructorDerivedClass.ts, 17, 1))
+
+class C4 extends C3 {}
+>C4 : Symbol(C4, Decl(typeGuardConstructorDerivedClass.ts, 20, 11))
+>C3 : Symbol(C3, Decl(typeGuardConstructorDerivedClass.ts, 17, 1))
+
+let var2: C4 | string;
+>var2 : Symbol(var2, Decl(typeGuardConstructorDerivedClass.ts, 24, 3))
+>C4 : Symbol(C4, Decl(typeGuardConstructorDerivedClass.ts, 20, 11))
+
+if (var2.constructor === C3) {
+>var2.constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>var2 : Symbol(var2, Decl(typeGuardConstructorDerivedClass.ts, 24, 3))
+>constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>C3 : Symbol(C3, Decl(typeGuardConstructorDerivedClass.ts, 17, 1))
+
+    var2; // never
+>var2 : Symbol(var2, Decl(typeGuardConstructorDerivedClass.ts, 24, 3))
+}
+if (var2.constructor === C4) {
+>var2.constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>var2 : Symbol(var2, Decl(typeGuardConstructorDerivedClass.ts, 24, 3))
+>constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>C4 : Symbol(C4, Decl(typeGuardConstructorDerivedClass.ts, 20, 11))
+
+    var2; // C4
+>var2 : Symbol(var2, Decl(typeGuardConstructorDerivedClass.ts, 24, 3))
+}
+
+// Disjointly structured classes
+class C5 {
+>C5 : Symbol(C5, Decl(typeGuardConstructorDerivedClass.ts, 30, 1))
+
+    property1: number;
+>property1 : Symbol(C5.property1, Decl(typeGuardConstructorDerivedClass.ts, 33, 10))
+}
+
+class C6 {
+>C6 : Symbol(C6, Decl(typeGuardConstructorDerivedClass.ts, 35, 1))
+
+    property2: number;
+>property2 : Symbol(C6.property2, Decl(typeGuardConstructorDerivedClass.ts, 37, 10))
+}
+
+let let3: C6 | string;
+>let3 : Symbol(let3, Decl(typeGuardConstructorDerivedClass.ts, 41, 3))
+>C6 : Symbol(C6, Decl(typeGuardConstructorDerivedClass.ts, 35, 1))
+
+if (let3.constructor === C5) {
+>let3.constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>let3 : Symbol(let3, Decl(typeGuardConstructorDerivedClass.ts, 41, 3))
+>constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>C5 : Symbol(C5, Decl(typeGuardConstructorDerivedClass.ts, 30, 1))
+
+    let3; // never
+>let3 : Symbol(let3, Decl(typeGuardConstructorDerivedClass.ts, 41, 3))
+}
+if (let3.constructor === C6) {
+>let3.constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>let3 : Symbol(let3, Decl(typeGuardConstructorDerivedClass.ts, 41, 3))
+>constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>C6 : Symbol(C6, Decl(typeGuardConstructorDerivedClass.ts, 35, 1))
+
+    let3; // C6
+>let3 : Symbol(let3, Decl(typeGuardConstructorDerivedClass.ts, 41, 3))
+}
+
+// Classes with the same structure
+class C7 {
+>C7 : Symbol(C7, Decl(typeGuardConstructorDerivedClass.ts, 47, 1))
+
+    property1: number
+>property1 : Symbol(C7.property1, Decl(typeGuardConstructorDerivedClass.ts, 50, 10))
+}
+
+class C8 {
+>C8 : Symbol(C8, Decl(typeGuardConstructorDerivedClass.ts, 52, 1))
+
+    property1: number;
+>property1 : Symbol(C8.property1, Decl(typeGuardConstructorDerivedClass.ts, 54, 10))
+}
+
+let let4: C8 | string;
+>let4 : Symbol(let4, Decl(typeGuardConstructorDerivedClass.ts, 58, 3))
+>C8 : Symbol(C8, Decl(typeGuardConstructorDerivedClass.ts, 52, 1))
+
+if (let4.constructor === C7) {
+>let4.constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>let4 : Symbol(let4, Decl(typeGuardConstructorDerivedClass.ts, 58, 3))
+>constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>C7 : Symbol(C7, Decl(typeGuardConstructorDerivedClass.ts, 47, 1))
+
+    let4; // never
+>let4 : Symbol(let4, Decl(typeGuardConstructorDerivedClass.ts, 58, 3))
+}
+if (let4.constructor === C8) {
+>let4.constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>let4 : Symbol(let4, Decl(typeGuardConstructorDerivedClass.ts, 58, 3))
+>constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>C8 : Symbol(C8, Decl(typeGuardConstructorDerivedClass.ts, 52, 1))
+
+    let4; // C8
+>let4 : Symbol(let4, Decl(typeGuardConstructorDerivedClass.ts, 58, 3))
+}
+
diff --git a/tests/baselines/reference/typeGuardConstructorDerivedClass.types b/tests/baselines/reference/typeGuardConstructorDerivedClass.types
new file mode 100644
index 0000000000000..3dc83b26e7dfe
--- /dev/null
+++ b/tests/baselines/reference/typeGuardConstructorDerivedClass.types
@@ -0,0 +1,161 @@
+=== tests/cases/compiler/typeGuardConstructorDerivedClass.ts ===
+// Derived class with different structures
+class C1 {
+>C1 : C1
+
+    property1: number;
+>property1 : number
+}
+
+class C2 extends C1 {
+>C2 : C2
+>C1 : C1
+
+    property2: number;
+>property2 : number
+}
+
+let var1: C2 | string;
+>var1 : string | C2
+
+if (var1.constructor === C1) {
+>var1.constructor === C1 : boolean
+>var1.constructor : Function
+>var1 : string | C2
+>constructor : Function
+>C1 : typeof C1
+
+    var1; // never
+>var1 : never
+
+    var1.property1; // error
+>var1.property1 : any
+>var1 : never
+>property1 : any
+}
+if (var1.constructor === C2) {
+>var1.constructor === C2 : boolean
+>var1.constructor : Function
+>var1 : string | C2
+>constructor : Function
+>C2 : typeof C2
+
+    var1; // C2
+>var1 : C2
+
+    var1.property1; // number
+>var1.property1 : number
+>var1 : C2
+>property1 : number
+}
+
+// Derived classes with the same structure
+class C3 {}
+>C3 : C3
+
+class C4 extends C3 {}
+>C4 : C4
+>C3 : C3
+
+let var2: C4 | string;
+>var2 : string | C4
+
+if (var2.constructor === C3) {
+>var2.constructor === C3 : boolean
+>var2.constructor : Function
+>var2 : string | C4
+>constructor : Function
+>C3 : typeof C3
+
+    var2; // never
+>var2 : never
+}
+if (var2.constructor === C4) {
+>var2.constructor === C4 : boolean
+>var2.constructor : Function
+>var2 : string | C4
+>constructor : Function
+>C4 : typeof C4
+
+    var2; // C4
+>var2 : C4
+}
+
+// Disjointly structured classes
+class C5 {
+>C5 : C5
+
+    property1: number;
+>property1 : number
+}
+
+class C6 {
+>C6 : C6
+
+    property2: number;
+>property2 : number
+}
+
+let let3: C6 | string;
+>let3 : string | C6
+
+if (let3.constructor === C5) {
+>let3.constructor === C5 : boolean
+>let3.constructor : Function
+>let3 : string | C6
+>constructor : Function
+>C5 : typeof C5
+
+    let3; // never
+>let3 : never
+}
+if (let3.constructor === C6) {
+>let3.constructor === C6 : boolean
+>let3.constructor : Function
+>let3 : string | C6
+>constructor : Function
+>C6 : typeof C6
+
+    let3; // C6
+>let3 : C6
+}
+
+// Classes with the same structure
+class C7 {
+>C7 : C7
+
+    property1: number
+>property1 : number
+}
+
+class C8 {
+>C8 : C8
+
+    property1: number;
+>property1 : number
+}
+
+let let4: C8 | string;
+>let4 : string | C8
+
+if (let4.constructor === C7) {
+>let4.constructor === C7 : boolean
+>let4.constructor : Function
+>let4 : string | C8
+>constructor : Function
+>C7 : typeof C7
+
+    let4; // never
+>let4 : never
+}
+if (let4.constructor === C8) {
+>let4.constructor === C8 : boolean
+>let4.constructor : Function
+>let4 : string | C8
+>constructor : Function
+>C8 : typeof C8
+
+    let4; // C8
+>let4 : C8
+}
+
diff --git a/tests/baselines/reference/typeGuardConstructorNarrowAny.js b/tests/baselines/reference/typeGuardConstructorNarrowAny.js
new file mode 100644
index 0000000000000..8fc189bbb8239
--- /dev/null
+++ b/tests/baselines/reference/typeGuardConstructorNarrowAny.js
@@ -0,0 +1,45 @@
+//// [typeGuardConstructorNarrowAny.ts]
+// Narrowing any to primitives
+let var1: any;
+
+if (var1.constructor === String) {
+    var1; // String
+}
+if (var1.constructor === Number) {
+    var1; // Number
+}
+if (var1.constructor === Boolean) {
+    var1; // Boolean
+}
+if (var1.constructor === Array) {
+    var1; // any[]
+}
+if (var1.constructor === Symbol) {
+    var1; // Symbol
+}
+if (var1.constructor === BigInt) {
+    var1; // BigInt
+}
+
+
+//// [typeGuardConstructorNarrowAny.js]
+// Narrowing any to primitives
+let var1;
+if (var1.constructor === String) {
+    var1; // String
+}
+if (var1.constructor === Number) {
+    var1; // Number
+}
+if (var1.constructor === Boolean) {
+    var1; // Boolean
+}
+if (var1.constructor === Array) {
+    var1; // any[]
+}
+if (var1.constructor === Symbol) {
+    var1; // Symbol
+}
+if (var1.constructor === BigInt) {
+    var1; // BigInt
+}
diff --git a/tests/baselines/reference/typeGuardConstructorNarrowAny.symbols b/tests/baselines/reference/typeGuardConstructorNarrowAny.symbols
new file mode 100644
index 0000000000000..acbc179aa270d
--- /dev/null
+++ b/tests/baselines/reference/typeGuardConstructorNarrowAny.symbols
@@ -0,0 +1,48 @@
+=== tests/cases/compiler/typeGuardConstructorNarrowAny.ts ===
+// Narrowing any to primitives
+let var1: any;
+>var1 : Symbol(var1, Decl(typeGuardConstructorNarrowAny.ts, 1, 3))
+
+if (var1.constructor === String) {
+>var1 : Symbol(var1, Decl(typeGuardConstructorNarrowAny.ts, 1, 3))
+>String : Symbol(String, Decl(lib.es5.d.ts, --, --), Decl(lib.es5.d.ts, --, --), Decl(lib.es5.d.ts, --, --), Decl(lib.es2015.core.d.ts, --, --), Decl(lib.es2015.iterable.d.ts, --, --) ... and 5 more)
+
+    var1; // String
+>var1 : Symbol(var1, Decl(typeGuardConstructorNarrowAny.ts, 1, 3))
+}
+if (var1.constructor === Number) {
+>var1 : Symbol(var1, Decl(typeGuardConstructorNarrowAny.ts, 1, 3))
+>Number : Symbol(Number, Decl(lib.es5.d.ts, --, --), Decl(lib.es5.d.ts, --, --), Decl(lib.es5.d.ts, --, --))
+
+    var1; // Number
+>var1 : Symbol(var1, Decl(typeGuardConstructorNarrowAny.ts, 1, 3))
+}
+if (var1.constructor === Boolean) {
+>var1 : Symbol(var1, Decl(typeGuardConstructorNarrowAny.ts, 1, 3))
+>Boolean : Symbol(Boolean, Decl(lib.es5.d.ts, --, --), Decl(lib.es5.d.ts, --, --))
+
+    var1; // Boolean
+>var1 : Symbol(var1, Decl(typeGuardConstructorNarrowAny.ts, 1, 3))
+}
+if (var1.constructor === Array) {
+>var1 : Symbol(var1, Decl(typeGuardConstructorNarrowAny.ts, 1, 3))
+>Array : Symbol(Array, Decl(lib.es5.d.ts, --, --), Decl(lib.es5.d.ts, --, --), Decl(lib.es2015.core.d.ts, --, --), Decl(lib.es2015.iterable.d.ts, --, --), Decl(lib.es2015.symbol.wellknown.d.ts, --, --) ... and 2 more)
+
+    var1; // any[]
+>var1 : Symbol(var1, Decl(typeGuardConstructorNarrowAny.ts, 1, 3))
+}
+if (var1.constructor === Symbol) {
+>var1 : Symbol(var1, Decl(typeGuardConstructorNarrowAny.ts, 1, 3))
+>Symbol : Symbol(Symbol, Decl(lib.es5.d.ts, --, --), Decl(lib.es2015.symbol.d.ts, --, --), Decl(lib.es2015.symbol.wellknown.d.ts, --, --), Decl(lib.es2019.symbol.d.ts, --, --))
+
+    var1; // Symbol
+>var1 : Symbol(var1, Decl(typeGuardConstructorNarrowAny.ts, 1, 3))
+}
+if (var1.constructor === BigInt) {
+>var1 : Symbol(var1, Decl(typeGuardConstructorNarrowAny.ts, 1, 3))
+>BigInt : Symbol(BigInt, Decl(lib.es2020.bigint.d.ts, --, --), Decl(lib.es2020.bigint.d.ts, --, --))
+
+    var1; // BigInt
+>var1 : Symbol(var1, Decl(typeGuardConstructorNarrowAny.ts, 1, 3))
+}
+
diff --git a/tests/baselines/reference/typeGuardConstructorNarrowAny.types b/tests/baselines/reference/typeGuardConstructorNarrowAny.types
new file mode 100644
index 0000000000000..a10d31a5384f0
--- /dev/null
+++ b/tests/baselines/reference/typeGuardConstructorNarrowAny.types
@@ -0,0 +1,66 @@
+=== tests/cases/compiler/typeGuardConstructorNarrowAny.ts ===
+// Narrowing any to primitives
+let var1: any;
+>var1 : any
+
+if (var1.constructor === String) {
+>var1.constructor === String : boolean
+>var1.constructor : any
+>var1 : any
+>constructor : any
+>String : StringConstructor
+
+    var1; // String
+>var1 : String
+}
+if (var1.constructor === Number) {
+>var1.constructor === Number : boolean
+>var1.constructor : any
+>var1 : any
+>constructor : any
+>Number : NumberConstructor
+
+    var1; // Number
+>var1 : Number
+}
+if (var1.constructor === Boolean) {
+>var1.constructor === Boolean : boolean
+>var1.constructor : any
+>var1 : any
+>constructor : any
+>Boolean : BooleanConstructor
+
+    var1; // Boolean
+>var1 : Boolean
+}
+if (var1.constructor === Array) {
+>var1.constructor === Array : boolean
+>var1.constructor : any
+>var1 : any
+>constructor : any
+>Array : ArrayConstructor
+
+    var1; // any[]
+>var1 : any[]
+}
+if (var1.constructor === Symbol) {
+>var1.constructor === Symbol : boolean
+>var1.constructor : any
+>var1 : any
+>constructor : any
+>Symbol : SymbolConstructor
+
+    var1; // Symbol
+>var1 : Symbol
+}
+if (var1.constructor === BigInt) {
+>var1.constructor === BigInt : boolean
+>var1.constructor : any
+>var1 : any
+>constructor : any
+>BigInt : BigIntConstructor
+
+    var1; // BigInt
+>var1 : BigInt
+}
+
diff --git a/tests/baselines/reference/typeGuardConstructorNarrowPrimitivesInUnion.js b/tests/baselines/reference/typeGuardConstructorNarrowPrimitivesInUnion.js
new file mode 100644
index 0000000000000..80afeb2ad36e4
--- /dev/null
+++ b/tests/baselines/reference/typeGuardConstructorNarrowPrimitivesInUnion.js
@@ -0,0 +1,36 @@
+//// [typeGuardConstructorNarrowPrimitivesInUnion.ts]
+// Union of primitives, number, arrays, and C1
+let var1: number | "hello" | "world" | true | false | number[] | string[];
+
+if (var1.constructor === Number) {
+    var1; // number
+}
+
+if (var1.constructor === String) {
+    var1; // "hello" | "world"
+}
+
+if (var1.constructor === Boolean) {
+    var1; // boolean
+}
+
+if (var1.constructor === Array) {
+    var1; // number[] | string[]
+}
+
+
+//// [typeGuardConstructorNarrowPrimitivesInUnion.js]
+// Union of primitives, number, arrays, and C1
+var var1;
+if (var1.constructor === Number) {
+    var1; // number
+}
+if (var1.constructor === String) {
+    var1; // "hello" | "world"
+}
+if (var1.constructor === Boolean) {
+    var1; // boolean
+}
+if (var1.constructor === Array) {
+    var1; // number[] | string[]
+}
diff --git a/tests/baselines/reference/typeGuardConstructorNarrowPrimitivesInUnion.symbols b/tests/baselines/reference/typeGuardConstructorNarrowPrimitivesInUnion.symbols
new file mode 100644
index 0000000000000..1fbbdefd76c2f
--- /dev/null
+++ b/tests/baselines/reference/typeGuardConstructorNarrowPrimitivesInUnion.symbols
@@ -0,0 +1,45 @@
+=== tests/cases/compiler/typeGuardConstructorNarrowPrimitivesInUnion.ts ===
+// Union of primitives, number, arrays, and C1
+let var1: number | "hello" | "world" | true | false | number[] | string[];
+>var1 : Symbol(var1, Decl(typeGuardConstructorNarrowPrimitivesInUnion.ts, 1, 3))
+
+if (var1.constructor === Number) {
+>var1.constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>var1 : Symbol(var1, Decl(typeGuardConstructorNarrowPrimitivesInUnion.ts, 1, 3))
+>constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>Number : Symbol(Number, Decl(lib.es5.d.ts, --, --), Decl(lib.es5.d.ts, --, --), Decl(lib.es5.d.ts, --, --))
+
+    var1; // number
+>var1 : Symbol(var1, Decl(typeGuardConstructorNarrowPrimitivesInUnion.ts, 1, 3))
+}
+
+if (var1.constructor === String) {
+>var1.constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>var1 : Symbol(var1, Decl(typeGuardConstructorNarrowPrimitivesInUnion.ts, 1, 3))
+>constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>String : Symbol(String, Decl(lib.es5.d.ts, --, --), Decl(lib.es5.d.ts, --, --), Decl(lib.es5.d.ts, --, --))
+
+    var1; // "hello" | "world"
+>var1 : Symbol(var1, Decl(typeGuardConstructorNarrowPrimitivesInUnion.ts, 1, 3))
+}
+
+if (var1.constructor === Boolean) {
+>var1.constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>var1 : Symbol(var1, Decl(typeGuardConstructorNarrowPrimitivesInUnion.ts, 1, 3))
+>constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>Boolean : Symbol(Boolean, Decl(lib.es5.d.ts, --, --), Decl(lib.es5.d.ts, --, --))
+
+    var1; // boolean
+>var1 : Symbol(var1, Decl(typeGuardConstructorNarrowPrimitivesInUnion.ts, 1, 3))
+}
+
+if (var1.constructor === Array) {
+>var1.constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>var1 : Symbol(var1, Decl(typeGuardConstructorNarrowPrimitivesInUnion.ts, 1, 3))
+>constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>Array : Symbol(Array, Decl(lib.es5.d.ts, --, --), Decl(lib.es5.d.ts, --, --))
+
+    var1; // number[] | string[]
+>var1 : Symbol(var1, Decl(typeGuardConstructorNarrowPrimitivesInUnion.ts, 1, 3))
+}
+
diff --git a/tests/baselines/reference/typeGuardConstructorNarrowPrimitivesInUnion.types b/tests/baselines/reference/typeGuardConstructorNarrowPrimitivesInUnion.types
new file mode 100644
index 0000000000000..619ce3b88bb21
--- /dev/null
+++ b/tests/baselines/reference/typeGuardConstructorNarrowPrimitivesInUnion.types
@@ -0,0 +1,51 @@
+=== tests/cases/compiler/typeGuardConstructorNarrowPrimitivesInUnion.ts ===
+// Union of primitives, number, arrays, and C1
+let var1: number | "hello" | "world" | true | false | number[] | string[];
+>var1 : number | boolean | "hello" | "world" | number[] | string[]
+>true : true
+>false : false
+
+if (var1.constructor === Number) {
+>var1.constructor === Number : boolean
+>var1.constructor : Function
+>var1 : number | boolean | "hello" | "world" | number[] | string[]
+>constructor : Function
+>Number : NumberConstructor
+
+    var1; // number
+>var1 : number
+}
+
+if (var1.constructor === String) {
+>var1.constructor === String : boolean
+>var1.constructor : Function
+>var1 : number | boolean | "hello" | "world" | number[] | string[]
+>constructor : Function
+>String : StringConstructor
+
+    var1; // "hello" | "world"
+>var1 : "hello" | "world"
+}
+
+if (var1.constructor === Boolean) {
+>var1.constructor === Boolean : boolean
+>var1.constructor : Function
+>var1 : number | boolean | "hello" | "world" | number[] | string[]
+>constructor : Function
+>Boolean : BooleanConstructor
+
+    var1; // boolean
+>var1 : boolean
+}
+
+if (var1.constructor === Array) {
+>var1.constructor === Array : boolean
+>var1.constructor : Function
+>var1 : number | boolean | "hello" | "world" | number[] | string[]
+>constructor : Function
+>Array : ArrayConstructor
+
+    var1; // number[] | string[]
+>var1 : number[] | string[]
+}
+
diff --git a/tests/baselines/reference/typeGuardConstructorPrimitiveTypes.js b/tests/baselines/reference/typeGuardConstructorPrimitiveTypes.js
new file mode 100644
index 0000000000000..3de66ac807a6f
--- /dev/null
+++ b/tests/baselines/reference/typeGuardConstructorPrimitiveTypes.js
@@ -0,0 +1,79 @@
+//// [typeGuardConstructorPrimitiveTypes.ts]
+// Narrow a union of primitive types
+let var1: string | number | boolean | any[] | symbol | bigint;
+if (var1.constructor === String) {
+    var1; // string
+}
+if (var1.constructor === Number) {
+    var1; // number
+}
+if (var1.constructor === Boolean) {
+    var1; // boolean
+}
+if (var1.constructor === Array) {
+    var1; // any[]
+}
+if (var1.constructor === Symbol) {
+    var1; // symbol
+}
+if (var1.constructor === BigInt) {
+    var1; // bigint
+}
+
+// Narrow a union of primitive object types
+let var2: String | Number | Boolean | Symbol | BigInt;
+if (var2.constructor === String) {
+    var2; // String
+}
+if (var2.constructor === Number) {
+    var2; // Number
+}
+if (var2.constructor === Boolean) {
+    var2; // Boolean
+}
+if (var2.constructor === Symbol) {
+    var2; // Symbol
+}
+if (var2.constructor === BigInt) {
+    var2; // BigInt
+}
+
+
+//// [typeGuardConstructorPrimitiveTypes.js]
+// Narrow a union of primitive types
+let var1;
+if (var1.constructor === String) {
+    var1; // string
+}
+if (var1.constructor === Number) {
+    var1; // number
+}
+if (var1.constructor === Boolean) {
+    var1; // boolean
+}
+if (var1.constructor === Array) {
+    var1; // any[]
+}
+if (var1.constructor === Symbol) {
+    var1; // symbol
+}
+if (var1.constructor === BigInt) {
+    var1; // bigint
+}
+// Narrow a union of primitive object types
+let var2;
+if (var2.constructor === String) {
+    var2; // String
+}
+if (var2.constructor === Number) {
+    var2; // Number
+}
+if (var2.constructor === Boolean) {
+    var2; // Boolean
+}
+if (var2.constructor === Symbol) {
+    var2; // Symbol
+}
+if (var2.constructor === BigInt) {
+    var2; // BigInt
+}
diff --git a/tests/baselines/reference/typeGuardConstructorPrimitiveTypes.symbols b/tests/baselines/reference/typeGuardConstructorPrimitiveTypes.symbols
new file mode 100644
index 0000000000000..1bcc2f586eb5e
--- /dev/null
+++ b/tests/baselines/reference/typeGuardConstructorPrimitiveTypes.symbols
@@ -0,0 +1,115 @@
+=== tests/cases/compiler/typeGuardConstructorPrimitiveTypes.ts ===
+// Narrow a union of primitive types
+let var1: string | number | boolean | any[] | symbol | bigint;
+>var1 : Symbol(var1, Decl(typeGuardConstructorPrimitiveTypes.ts, 1, 3))
+
+if (var1.constructor === String) {
+>var1.constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>var1 : Symbol(var1, Decl(typeGuardConstructorPrimitiveTypes.ts, 1, 3))
+>constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>String : Symbol(String, Decl(lib.es5.d.ts, --, --), Decl(lib.es5.d.ts, --, --), Decl(lib.es5.d.ts, --, --), Decl(lib.es2015.core.d.ts, --, --), Decl(lib.es2015.iterable.d.ts, --, --) ... and 5 more)
+
+    var1; // string
+>var1 : Symbol(var1, Decl(typeGuardConstructorPrimitiveTypes.ts, 1, 3))
+}
+if (var1.constructor === Number) {
+>var1.constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>var1 : Symbol(var1, Decl(typeGuardConstructorPrimitiveTypes.ts, 1, 3))
+>constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>Number : Symbol(Number, Decl(lib.es5.d.ts, --, --), Decl(lib.es5.d.ts, --, --), Decl(lib.es5.d.ts, --, --))
+
+    var1; // number
+>var1 : Symbol(var1, Decl(typeGuardConstructorPrimitiveTypes.ts, 1, 3))
+}
+if (var1.constructor === Boolean) {
+>var1.constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>var1 : Symbol(var1, Decl(typeGuardConstructorPrimitiveTypes.ts, 1, 3))
+>constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>Boolean : Symbol(Boolean, Decl(lib.es5.d.ts, --, --), Decl(lib.es5.d.ts, --, --))
+
+    var1; // boolean
+>var1 : Symbol(var1, Decl(typeGuardConstructorPrimitiveTypes.ts, 1, 3))
+}
+if (var1.constructor === Array) {
+>var1.constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>var1 : Symbol(var1, Decl(typeGuardConstructorPrimitiveTypes.ts, 1, 3))
+>constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>Array : Symbol(Array, Decl(lib.es5.d.ts, --, --), Decl(lib.es5.d.ts, --, --), Decl(lib.es2015.core.d.ts, --, --), Decl(lib.es2015.iterable.d.ts, --, --), Decl(lib.es2015.symbol.wellknown.d.ts, --, --) ... and 2 more)
+
+    var1; // any[]
+>var1 : Symbol(var1, Decl(typeGuardConstructorPrimitiveTypes.ts, 1, 3))
+}
+if (var1.constructor === Symbol) {
+>var1.constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>var1 : Symbol(var1, Decl(typeGuardConstructorPrimitiveTypes.ts, 1, 3))
+>constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>Symbol : Symbol(Symbol, Decl(lib.es5.d.ts, --, --), Decl(lib.es2015.symbol.d.ts, --, --), Decl(lib.es2015.symbol.wellknown.d.ts, --, --), Decl(lib.es2019.symbol.d.ts, --, --))
+
+    var1; // symbol
+>var1 : Symbol(var1, Decl(typeGuardConstructorPrimitiveTypes.ts, 1, 3))
+}
+if (var1.constructor === BigInt) {
+>var1.constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>var1 : Symbol(var1, Decl(typeGuardConstructorPrimitiveTypes.ts, 1, 3))
+>constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>BigInt : Symbol(BigInt, Decl(lib.es2020.bigint.d.ts, --, --), Decl(lib.es2020.bigint.d.ts, --, --))
+
+    var1; // bigint
+>var1 : Symbol(var1, Decl(typeGuardConstructorPrimitiveTypes.ts, 1, 3))
+}
+
+// Narrow a union of primitive object types
+let var2: String | Number | Boolean | Symbol | BigInt;
+>var2 : Symbol(var2, Decl(typeGuardConstructorPrimitiveTypes.ts, 22, 3))
+>String : Symbol(String, Decl(lib.es5.d.ts, --, --), Decl(lib.es5.d.ts, --, --), Decl(lib.es5.d.ts, --, --), Decl(lib.es2015.core.d.ts, --, --), Decl(lib.es2015.iterable.d.ts, --, --) ... and 5 more)
+>Number : Symbol(Number, Decl(lib.es5.d.ts, --, --), Decl(lib.es5.d.ts, --, --), Decl(lib.es5.d.ts, --, --))
+>Boolean : Symbol(Boolean, Decl(lib.es5.d.ts, --, --), Decl(lib.es5.d.ts, --, --))
+>Symbol : Symbol(Symbol, Decl(lib.es5.d.ts, --, --), Decl(lib.es2015.symbol.d.ts, --, --), Decl(lib.es2015.symbol.wellknown.d.ts, --, --), Decl(lib.es2019.symbol.d.ts, --, --))
+>BigInt : Symbol(BigInt, Decl(lib.es2020.bigint.d.ts, --, --), Decl(lib.es2020.bigint.d.ts, --, --))
+
+if (var2.constructor === String) {
+>var2.constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>var2 : Symbol(var2, Decl(typeGuardConstructorPrimitiveTypes.ts, 22, 3))
+>constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>String : Symbol(String, Decl(lib.es5.d.ts, --, --), Decl(lib.es5.d.ts, --, --), Decl(lib.es5.d.ts, --, --), Decl(lib.es2015.core.d.ts, --, --), Decl(lib.es2015.iterable.d.ts, --, --) ... and 5 more)
+
+    var2; // String
+>var2 : Symbol(var2, Decl(typeGuardConstructorPrimitiveTypes.ts, 22, 3))
+}
+if (var2.constructor === Number) {
+>var2.constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>var2 : Symbol(var2, Decl(typeGuardConstructorPrimitiveTypes.ts, 22, 3))
+>constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>Number : Symbol(Number, Decl(lib.es5.d.ts, --, --), Decl(lib.es5.d.ts, --, --), Decl(lib.es5.d.ts, --, --))
+
+    var2; // Number
+>var2 : Symbol(var2, Decl(typeGuardConstructorPrimitiveTypes.ts, 22, 3))
+}
+if (var2.constructor === Boolean) {
+>var2.constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>var2 : Symbol(var2, Decl(typeGuardConstructorPrimitiveTypes.ts, 22, 3))
+>constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>Boolean : Symbol(Boolean, Decl(lib.es5.d.ts, --, --), Decl(lib.es5.d.ts, --, --))
+
+    var2; // Boolean
+>var2 : Symbol(var2, Decl(typeGuardConstructorPrimitiveTypes.ts, 22, 3))
+}
+if (var2.constructor === Symbol) {
+>var2.constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>var2 : Symbol(var2, Decl(typeGuardConstructorPrimitiveTypes.ts, 22, 3))
+>constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>Symbol : Symbol(Symbol, Decl(lib.es5.d.ts, --, --), Decl(lib.es2015.symbol.d.ts, --, --), Decl(lib.es2015.symbol.wellknown.d.ts, --, --), Decl(lib.es2019.symbol.d.ts, --, --))
+
+    var2; // Symbol
+>var2 : Symbol(var2, Decl(typeGuardConstructorPrimitiveTypes.ts, 22, 3))
+}
+if (var2.constructor === BigInt) {
+>var2.constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>var2 : Symbol(var2, Decl(typeGuardConstructorPrimitiveTypes.ts, 22, 3))
+>constructor : Symbol(Object.constructor, Decl(lib.es5.d.ts, --, --))
+>BigInt : Symbol(BigInt, Decl(lib.es2020.bigint.d.ts, --, --), Decl(lib.es2020.bigint.d.ts, --, --))
+
+    var2; // BigInt
+>var2 : Symbol(var2, Decl(typeGuardConstructorPrimitiveTypes.ts, 22, 3))
+}
+
diff --git a/tests/baselines/reference/typeGuardConstructorPrimitiveTypes.types b/tests/baselines/reference/typeGuardConstructorPrimitiveTypes.types
new file mode 100644
index 0000000000000..c23ae9e8decff
--- /dev/null
+++ b/tests/baselines/reference/typeGuardConstructorPrimitiveTypes.types
@@ -0,0 +1,121 @@
+=== tests/cases/compiler/typeGuardConstructorPrimitiveTypes.ts ===
+// Narrow a union of primitive types
+let var1: string | number | boolean | any[] | symbol | bigint;
+>var1 : string | number | bigint | boolean | symbol | any[]
+
+if (var1.constructor === String) {
+>var1.constructor === String : boolean
+>var1.constructor : Function
+>var1 : string | number | bigint | boolean | symbol | any[]
+>constructor : Function
+>String : StringConstructor
+
+    var1; // string
+>var1 : string
+}
+if (var1.constructor === Number) {
+>var1.constructor === Number : boolean
+>var1.constructor : Function
+>var1 : string | number | bigint | boolean | symbol | any[]
+>constructor : Function
+>Number : NumberConstructor
+
+    var1; // number
+>var1 : number
+}
+if (var1.constructor === Boolean) {
+>var1.constructor === Boolean : boolean
+>var1.constructor : Function
+>var1 : string | number | bigint | boolean | symbol | any[]
+>constructor : Function
+>Boolean : BooleanConstructor
+
+    var1; // boolean
+>var1 : boolean
+}
+if (var1.constructor === Array) {
+>var1.constructor === Array : boolean
+>var1.constructor : Function
+>var1 : string | number | bigint | boolean | symbol | any[]
+>constructor : Function
+>Array : ArrayConstructor
+
+    var1; // any[]
+>var1 : any[]
+}
+if (var1.constructor === Symbol) {
+>var1.constructor === Symbol : boolean
+>var1.constructor : Function
+>var1 : string | number | bigint | boolean | symbol | any[]
+>constructor : Function
+>Symbol : SymbolConstructor
+
+    var1; // symbol
+>var1 : symbol
+}
+if (var1.constructor === BigInt) {
+>var1.constructor === BigInt : boolean
+>var1.constructor : Function
+>var1 : string | number | bigint | boolean | symbol | any[]
+>constructor : Function
+>BigInt : BigIntConstructor
+
+    var1; // bigint
+>var1 : bigint
+}
+
+// Narrow a union of primitive object types
+let var2: String | Number | Boolean | Symbol | BigInt;
+>var2 : String | Number | Boolean | BigInt | Symbol
+
+if (var2.constructor === String) {
+>var2.constructor === String : boolean
+>var2.constructor : Function
+>var2 : String | Number | Boolean | BigInt | Symbol
+>constructor : Function
+>String : StringConstructor
+
+    var2; // String
+>var2 : String
+}
+if (var2.constructor === Number) {
+>var2.constructor === Number : boolean
+>var2.constructor : Function
+>var2 : String | Number | Boolean | BigInt | Symbol
+>constructor : Function
+>Number : NumberConstructor
+
+    var2; // Number
+>var2 : Number
+}
+if (var2.constructor === Boolean) {
+>var2.constructor === Boolean : boolean
+>var2.constructor : Function
+>var2 : String | Number | Boolean | BigInt | Symbol
+>constructor : Function
+>Boolean : BooleanConstructor
+
+    var2; // Boolean
+>var2 : Boolean
+}
+if (var2.constructor === Symbol) {
+>var2.constructor === Symbol : boolean
+>var2.constructor : Function
+>var2 : String | Number | Boolean | BigInt | Symbol
+>constructor : Function
+>Symbol : SymbolConstructor
+
+    var2; // Symbol
+>var2 : Symbol
+}
+if (var2.constructor === BigInt) {
+>var2.constructor === BigInt : boolean
+>var2.constructor : Function
+>var2 : String | Number | Boolean | BigInt | Symbol
+>constructor : Function
+>BigInt : BigIntConstructor
+
+    var2; // BigInt
+>var2 : BigInt
+}
+
diff --git a/tests/cases/compiler/typeGuardConstructorClassAndNumber.ts b/tests/cases/compiler/typeGuardConstructorClassAndNumber.ts
new file mode 100644
index 0000000000000..10ce6afdff05f
--- /dev/null
+++ b/tests/cases/compiler/typeGuardConstructorClassAndNumber.ts
@@ -0,0 +1,119 @@
+// Typical case
+class C1 {
+    property1: string;
+}
+
+let var1: C1 | number;
+if (var1.constructor == C1) {
+    var1; // C1
+    var1.property1; // string
+}
+else {
+    var1; // number | C1
+}
+if (var1["constructor"] == C1) {
+    var1; // C1
+    var1.property1; // string
+}
+else {
+    var1; // number | C1
+}
+if (var1.constructor === C1) {
+    var1; // C1
+    var1.property1; // string
+}
+else {
+    var1; // number | C1
+}
+if (var1["constructor"] === C1) {
+    var1; // C1
+    var1.property1; // string
+}
+else {
+    var1; // number | C1
+}
+if (C1 == var1.constructor) {
+    var1; // C1
+    var1.property1; // string
+}
+else {
+    var1; // number | C1
+}
+if (C1 == var1["constructor"]) {
+    var1; // C1
+    var1.property1; // string
+}
+else {
+    var1; // number | C1
+}
+if (C1 === var1.constructor) {
+    var1; // C1
+    var1.property1; // string
+}
+else {
+    var1; // number | C1
+}
+if (C1 === var1["constructor"]) {
+    var1; // C1
+    var1.property1; // string
+}
+else {
+    var1; // number | C1
+}
+
+if (var1.constructor != C1) {
+    var1; // C1 | number
+    var1.property1; // error
+}
+else {
+    var1; // C1
+}
+if (var1["constructor"] != C1) {
+    var1; // C1 | number
+    var1.property1; // error
+}
+else {
+    var1; // C1
+}
+if (var1.constructor !== C1) {
+    var1; // C1 | number
+    var1.property1; // error
+}
+else {
+    var1; // C1
+}
+if (var1["constructor"] !== C1) {
+    var1; // C1 | number
+    var1.property1; // error
+}
+else {
+    var1; // C1
+}
+if (C1 != var1.constructor) {
+    var1; // C1 | number
+    var1.property1; // error
+}
+else {
+    var1; // C1
+}
+if (C1 != var1["constructor"]) {
+    var1; // C1 | number
+    var1.property1; // error
+}
+else {
+    var1; // C1
+}
+if (C1 !== var1.constructor) {
+    var1; // C1 | number
+    var1.property1; // error
+}
+else {
+    var1; // C1
+}
+if (C1 !== var1["constructor"]) {
+    var1; // C1 | number
+    var1.property1; // error
+}
+else {
+    var1; // C1
+}
diff --git a/tests/cases/compiler/typeGuardConstructorDerivedClass.ts b/tests/cases/compiler/typeGuardConstructorDerivedClass.ts
new file mode 100644
index 0000000000000..5bca75c7a010b
--- /dev/null
+++ b/tests/cases/compiler/typeGuardConstructorDerivedClass.ts
@@ -0,0 +1,65 @@
+// Derived class with different structures
+class C1 {
+    property1: number;
+}
+
+class C2 extends C1 {
+    property2: number;
+}
+
+let var1: C2 | string;
+if (var1.constructor === C1) {
+    var1; // never
+    var1.property1; // error
+}
+if (var1.constructor === C2) {
+    var1; // C2
+    var1.property1; // number
+}
+
+// Derived classes with the same structure
+class C3 {}
+
+class C4 extends C3 {}
+
+let var2: C4 | string;
+if (var2.constructor === C3) {
+    var2; // never
+}
+if (var2.constructor === C4) {
+    var2; // C4
+}
+
+// Disjointly structured classes
+class C5 {
+    property1: number;
+}
+
+class C6 {
+    property2: number;
+}
+
+let let3: C6 | string;
+if (let3.constructor === C5) {
+    let3; // never
+}
+if (let3.constructor === C6) {
+    let3; // C6
+}
+
+// Classes with the same structure
+class C7 {
+    property1: number
+}
+
+class C8 {
+    property1: number;
+}
+
+let let4: C8 | string;
+if (let4.constructor === C7) {
+    let4; // never
+}
+if (let4.constructor === C8) {
+    let4; // C8
+}
diff --git a/tests/cases/compiler/typeGuardConstructorNarrowAny.ts b/tests/cases/compiler/typeGuardConstructorNarrowAny.ts
new file mode 100644
index 0000000000000..4f0703dc638fb
--- /dev/null
+++ b/tests/cases/compiler/typeGuardConstructorNarrowAny.ts
@@ -0,0 +1,23 @@
+// @target: esnext
+
+// Narrowing any to primitives
+let var1: any;
+
+if (var1.constructor === String) {
+    var1; // String
+}
+if (var1.constructor === Number) {
+    var1; // Number
+}
+if (var1.constructor === Boolean) {
+    var1; // Boolean
+}
+if (var1.constructor === Array) {
+    var1; // any[]
+}
+if (var1.constructor === Symbol) {
+    var1; // Symbol
+}
+if (var1.constructor === BigInt) {
+    var1; // BigInt
+}
diff --git a/tests/cases/compiler/typeGuardConstructorNarrowPrimitivesInUnion.ts b/tests/cases/compiler/typeGuardConstructorNarrowPrimitivesInUnion.ts
new file mode 100644
index 0000000000000..596b7d8416352
--- /dev/null
+++ b/tests/cases/compiler/typeGuardConstructorNarrowPrimitivesInUnion.ts
@@ -0,0 +1,18 @@
+// Union of primitives, number, arrays, and C1
+let var1: number | "hello" | "world" | true | false | number[] | string[];
+
+if (var1.constructor === Number) {
+    var1; // number
+}
+
+if (var1.constructor === String) {
+    var1; // "hello" | "world"
+}
+
+if (var1.constructor === Boolean) {
+    var1; // boolean
+}
+
+if (var1.constructor === Array) {
+    var1; // number[] | string[]
+}
diff --git a/tests/cases/compiler/typeGuardConstructorPrimitiveTypes.ts b/tests/cases/compiler/typeGuardConstructorPrimitiveTypes.ts
new file mode 100644
index 0000000000000..9ddb2d61247e7
--- /dev/null
+++ b/tests/cases/compiler/typeGuardConstructorPrimitiveTypes.ts
@@ -0,0 +1,40 @@
+// @target: esnext
+
+// Narrow a union of primitive types
+let var1: string | number | boolean | any[] | symbol | bigint;
+if (var1.constructor === String) {
+    var1; // string
+}
+if (var1.constructor === Number) {
+    var1; // number
+}
+if (var1.constructor === Boolean) {
+    var1; // boolean
+}
+if (var1.constructor === Array) {
+    var1; // any[]
+}
+if (var1.constructor === Symbol) {
+    var1; // symbol
+}
+if (var1.constructor === BigInt) {
+    var1; // bigint
+}
+
+// Narrow a union of primitive object types
+let var2: String | Number | Boolean | Symbol | BigInt;
+if (var2.constructor === String) {
+    var2; // String
+}
+if (var2.constructor === Number) {
+    var2; // Number
+}
+if (var2.constructor === Boolean) {
+    var2; // Boolean
+}
+if (var2.constructor === Symbol) {
+    var2; // Symbol
+}
+if (var2.constructor === BigInt) {
+    var2; // BigInt
+}