diff --git a/src/compiler/checker.ts b/src/compiler/checker.ts
index 282765dcc7b1d..c85414fbcef0d 100644
--- a/src/compiler/checker.ts
+++ b/src/compiler/checker.ts
@@ -6631,6 +6631,9 @@ namespace ts {
             else if (type.flags & TypeFlags.Intersection) {
                 return getIntersectionType(map((<IntersectionType>type).types, t => getTypeWithThisArgument(t, thisArgument, needApparentType)));
             }
+            else if (type.flags & TypeFlags.TypeParameter && thisArgument && (type as TypeParameter).isThisType) {
+                return getTypeWithThisArgument(createTypeReference(globalThisType, [type]), needApparentType ? instantiateType(thisArgument, createTypeMapper([type], [getApparentType(type)])) : thisArgument, needApparentType);
+            }
             return needApparentType ? getApparentType(type) : type;
         }
 
@@ -6685,6 +6688,23 @@ namespace ts {
         }
 
         function resolveTypeReferenceMembers(type: TypeReference): void {
+
+            if (type.target === globalThisType && type.typeArguments && type.typeArguments[0].flags & TypeFlags.TypeParameter &&
+                (type.typeArguments[0] as TypeParameter).isThisType && type.typeArguments[1]) {
+                if (type.typeArguments[1].flags & TypeFlags.StructuredType) {
+                    const instantiatedTarget = instantiateType(type.typeArguments[1], createTypeMapper([type.typeArguments[0]], [type.typeArguments[1]]));
+                    const props = getPropertiesOfType(instantiatedTarget);
+                    const calls = getSignaturesOfType(instantiatedTarget, SignatureKind.Call);
+                    const ctors = getSignaturesOfType(instantiatedTarget, SignatureKind.Construct);
+                    const strIndex = getIndexInfoOfType(instantiatedTarget, IndexKind.String);
+                    const numIndex = getIndexInfoOfType(instantiatedTarget, IndexKind.Number);
+                    setStructuredTypeMembers(type, createMapFromEntries(props.map(p => [p.escapedName, p]) as [string, Symbol][]) as SymbolTable, calls, ctors, strIndex, numIndex);
+                }
+                else {
+                    setStructuredTypeMembers(type, emptySymbols, emptyArray, emptyArray, /*stringIndexInfo*/ undefined, /*numberIndexInfo*/ undefined);
+                }
+                return;
+            }
             const source = resolveDeclaredMembers(type.target);
             const typeParameters = concatenate(source.typeParameters!, [source.thisType!]);
             const typeArguments = type.typeArguments && type.typeArguments.length === typeParameters.length ?
diff --git a/tests/baselines/reference/chainedThisRefinements.js b/tests/baselines/reference/chainedThisRefinements.js
new file mode 100644
index 0000000000000..ca743711b421b
--- /dev/null
+++ b/tests/baselines/reference/chainedThisRefinements.js
@@ -0,0 +1,48 @@
+//// [chainedThisRefinements.ts]
+class Builder {
+    private _class: undefined;
+    withFoo<T>() {
+        return this as this & { foo: T }
+    }
+    withBar<T>() {
+        return this as this & { bar: T }
+    }
+    withFooBar<T>() {
+        this.withFoo<T>().withBar<T>().foo;
+        this.withFoo<T>().withBar<T>().bar;
+        return this.withFoo<T>().withBar<T>();
+    }
+}
+
+declare var f: {foo: number};
+new Builder().withFoo<number>().withBar<number>().foo;
+new Builder().withFoo<number>().withBar<number>().bar;
+f = new Builder().withFoo<number>().withBar<number>();
+new Builder().withFooBar<number>().foo;
+new Builder().withFooBar<number>().bar;
+f = new Builder().withFooBar<number>();
+
+
+//// [chainedThisRefinements.js]
+var Builder = /** @class */ (function () {
+    function Builder() {
+    }
+    Builder.prototype.withFoo = function () {
+        return this;
+    };
+    Builder.prototype.withBar = function () {
+        return this;
+    };
+    Builder.prototype.withFooBar = function () {
+        this.withFoo().withBar().foo;
+        this.withFoo().withBar().bar;
+        return this.withFoo().withBar();
+    };
+    return Builder;
+}());
+new Builder().withFoo().withBar().foo;
+new Builder().withFoo().withBar().bar;
+f = new Builder().withFoo().withBar();
+new Builder().withFooBar().foo;
+new Builder().withFooBar().bar;
+f = new Builder().withFooBar();
diff --git a/tests/baselines/reference/chainedThisRefinements.symbols b/tests/baselines/reference/chainedThisRefinements.symbols
new file mode 100644
index 0000000000000..668fd977418f7
--- /dev/null
+++ b/tests/baselines/reference/chainedThisRefinements.symbols
@@ -0,0 +1,112 @@
+=== tests/cases/compiler/chainedThisRefinements.ts ===
+class Builder {
+>Builder : Symbol(Builder, Decl(chainedThisRefinements.ts, 0, 0))
+
+    private _class: undefined;
+>_class : Symbol(Builder._class, Decl(chainedThisRefinements.ts, 0, 15))
+
+    withFoo<T>() {
+>withFoo : Symbol(Builder.withFoo, Decl(chainedThisRefinements.ts, 1, 30))
+>T : Symbol(T, Decl(chainedThisRefinements.ts, 2, 12))
+
+        return this as this & { foo: T }
+>this : Symbol(Builder, Decl(chainedThisRefinements.ts, 0, 0))
+>foo : Symbol(foo, Decl(chainedThisRefinements.ts, 3, 31))
+>T : Symbol(T, Decl(chainedThisRefinements.ts, 2, 12))
+    }
+    withBar<T>() {
+>withBar : Symbol(Builder.withBar, Decl(chainedThisRefinements.ts, 4, 5))
+>T : Symbol(T, Decl(chainedThisRefinements.ts, 5, 12))
+
+        return this as this & { bar: T }
+>this : Symbol(Builder, Decl(chainedThisRefinements.ts, 0, 0))
+>bar : Symbol(bar, Decl(chainedThisRefinements.ts, 6, 31))
+>T : Symbol(T, Decl(chainedThisRefinements.ts, 5, 12))
+    }
+    withFooBar<T>() {
+>withFooBar : Symbol(Builder.withFooBar, Decl(chainedThisRefinements.ts, 7, 5))
+>T : Symbol(T, Decl(chainedThisRefinements.ts, 8, 15))
+
+        this.withFoo<T>().withBar<T>().foo;
+>this.withFoo<T>().withBar<T>().foo : Symbol(foo, Decl(chainedThisRefinements.ts, 3, 31))
+>this.withFoo<T>().withBar : Symbol(Builder.withBar, Decl(chainedThisRefinements.ts, 4, 5))
+>this.withFoo : Symbol(Builder.withFoo, Decl(chainedThisRefinements.ts, 1, 30))
+>this : Symbol(Builder, Decl(chainedThisRefinements.ts, 0, 0))
+>withFoo : Symbol(Builder.withFoo, Decl(chainedThisRefinements.ts, 1, 30))
+>T : Symbol(T, Decl(chainedThisRefinements.ts, 8, 15))
+>withBar : Symbol(Builder.withBar, Decl(chainedThisRefinements.ts, 4, 5))
+>T : Symbol(T, Decl(chainedThisRefinements.ts, 8, 15))
+>foo : Symbol(foo, Decl(chainedThisRefinements.ts, 3, 31))
+
+        this.withFoo<T>().withBar<T>().bar;
+>this.withFoo<T>().withBar<T>().bar : Symbol(bar, Decl(chainedThisRefinements.ts, 6, 31))
+>this.withFoo<T>().withBar : Symbol(Builder.withBar, Decl(chainedThisRefinements.ts, 4, 5))
+>this.withFoo : Symbol(Builder.withFoo, Decl(chainedThisRefinements.ts, 1, 30))
+>this : Symbol(Builder, Decl(chainedThisRefinements.ts, 0, 0))
+>withFoo : Symbol(Builder.withFoo, Decl(chainedThisRefinements.ts, 1, 30))
+>T : Symbol(T, Decl(chainedThisRefinements.ts, 8, 15))
+>withBar : Symbol(Builder.withBar, Decl(chainedThisRefinements.ts, 4, 5))
+>T : Symbol(T, Decl(chainedThisRefinements.ts, 8, 15))
+>bar : Symbol(bar, Decl(chainedThisRefinements.ts, 6, 31))
+
+        return this.withFoo<T>().withBar<T>();
+>this.withFoo<T>().withBar : Symbol(Builder.withBar, Decl(chainedThisRefinements.ts, 4, 5))
+>this.withFoo : Symbol(Builder.withFoo, Decl(chainedThisRefinements.ts, 1, 30))
+>this : Symbol(Builder, Decl(chainedThisRefinements.ts, 0, 0))
+>withFoo : Symbol(Builder.withFoo, Decl(chainedThisRefinements.ts, 1, 30))
+>T : Symbol(T, Decl(chainedThisRefinements.ts, 8, 15))
+>withBar : Symbol(Builder.withBar, Decl(chainedThisRefinements.ts, 4, 5))
+>T : Symbol(T, Decl(chainedThisRefinements.ts, 8, 15))
+    }
+}
+
+declare var f: {foo: number};
+>f : Symbol(f, Decl(chainedThisRefinements.ts, 15, 11))
+>foo : Symbol(foo, Decl(chainedThisRefinements.ts, 15, 16))
+
+new Builder().withFoo<number>().withBar<number>().foo;
+>new Builder().withFoo<number>().withBar<number>().foo : Symbol(foo, Decl(chainedThisRefinements.ts, 3, 31))
+>new Builder().withFoo<number>().withBar : Symbol(Builder.withBar, Decl(chainedThisRefinements.ts, 4, 5))
+>new Builder().withFoo : Symbol(Builder.withFoo, Decl(chainedThisRefinements.ts, 1, 30))
+>Builder : Symbol(Builder, Decl(chainedThisRefinements.ts, 0, 0))
+>withFoo : Symbol(Builder.withFoo, Decl(chainedThisRefinements.ts, 1, 30))
+>withBar : Symbol(Builder.withBar, Decl(chainedThisRefinements.ts, 4, 5))
+>foo : Symbol(foo, Decl(chainedThisRefinements.ts, 3, 31))
+
+new Builder().withFoo<number>().withBar<number>().bar;
+>new Builder().withFoo<number>().withBar<number>().bar : Symbol(bar, Decl(chainedThisRefinements.ts, 6, 31))
+>new Builder().withFoo<number>().withBar : Symbol(Builder.withBar, Decl(chainedThisRefinements.ts, 4, 5))
+>new Builder().withFoo : Symbol(Builder.withFoo, Decl(chainedThisRefinements.ts, 1, 30))
+>Builder : Symbol(Builder, Decl(chainedThisRefinements.ts, 0, 0))
+>withFoo : Symbol(Builder.withFoo, Decl(chainedThisRefinements.ts, 1, 30))
+>withBar : Symbol(Builder.withBar, Decl(chainedThisRefinements.ts, 4, 5))
+>bar : Symbol(bar, Decl(chainedThisRefinements.ts, 6, 31))
+
+f = new Builder().withFoo<number>().withBar<number>();
+>f : Symbol(f, Decl(chainedThisRefinements.ts, 15, 11))
+>new Builder().withFoo<number>().withBar : Symbol(Builder.withBar, Decl(chainedThisRefinements.ts, 4, 5))
+>new Builder().withFoo : Symbol(Builder.withFoo, Decl(chainedThisRefinements.ts, 1, 30))
+>Builder : Symbol(Builder, Decl(chainedThisRefinements.ts, 0, 0))
+>withFoo : Symbol(Builder.withFoo, Decl(chainedThisRefinements.ts, 1, 30))
+>withBar : Symbol(Builder.withBar, Decl(chainedThisRefinements.ts, 4, 5))
+
+new Builder().withFooBar<number>().foo;
+>new Builder().withFooBar<number>().foo : Symbol(foo, Decl(chainedThisRefinements.ts, 3, 31))
+>new Builder().withFooBar : Symbol(Builder.withFooBar, Decl(chainedThisRefinements.ts, 7, 5))
+>Builder : Symbol(Builder, Decl(chainedThisRefinements.ts, 0, 0))
+>withFooBar : Symbol(Builder.withFooBar, Decl(chainedThisRefinements.ts, 7, 5))
+>foo : Symbol(foo, Decl(chainedThisRefinements.ts, 3, 31))
+
+new Builder().withFooBar<number>().bar;
+>new Builder().withFooBar<number>().bar : Symbol(bar, Decl(chainedThisRefinements.ts, 6, 31))
+>new Builder().withFooBar : Symbol(Builder.withFooBar, Decl(chainedThisRefinements.ts, 7, 5))
+>Builder : Symbol(Builder, Decl(chainedThisRefinements.ts, 0, 0))
+>withFooBar : Symbol(Builder.withFooBar, Decl(chainedThisRefinements.ts, 7, 5))
+>bar : Symbol(bar, Decl(chainedThisRefinements.ts, 6, 31))
+
+f = new Builder().withFooBar<number>();
+>f : Symbol(f, Decl(chainedThisRefinements.ts, 15, 11))
+>new Builder().withFooBar : Symbol(Builder.withFooBar, Decl(chainedThisRefinements.ts, 7, 5))
+>Builder : Symbol(Builder, Decl(chainedThisRefinements.ts, 0, 0))
+>withFooBar : Symbol(Builder.withFooBar, Decl(chainedThisRefinements.ts, 7, 5))
+
diff --git a/tests/baselines/reference/chainedThisRefinements.types b/tests/baselines/reference/chainedThisRefinements.types
new file mode 100644
index 0000000000000..6b03ee427d365
--- /dev/null
+++ b/tests/baselines/reference/chainedThisRefinements.types
@@ -0,0 +1,126 @@
+=== tests/cases/compiler/chainedThisRefinements.ts ===
+class Builder {
+>Builder : Builder
+
+    private _class: undefined;
+>_class : undefined
+
+    withFoo<T>() {
+>withFoo : <T>() => this & { foo: T; }
+
+        return this as this & { foo: T }
+>this as this & { foo: T } : this & { foo: T; }
+>this : this
+>foo : T
+    }
+    withBar<T>() {
+>withBar : <T>() => this & { bar: T; }
+
+        return this as this & { bar: T }
+>this as this & { bar: T } : this & { bar: T; }
+>this : this
+>bar : T
+    }
+    withFooBar<T>() {
+>withFooBar : <T>() => Builder & { foo: T; } & { bar: T; }
+
+        this.withFoo<T>().withBar<T>().foo;
+>this.withFoo<T>().withBar<T>().foo : T
+>this.withFoo<T>().withBar<T>() : Builder & { foo: T; } & { bar: T; }
+>this.withFoo<T>().withBar : <T>() => Builder & { foo: T; } & { bar: T; }
+>this.withFoo<T>() : this & { foo: T; }
+>this.withFoo : <T>() => this & { foo: T; }
+>this : this
+>withFoo : <T>() => this & { foo: T; }
+>withBar : <T>() => Builder & { foo: T; } & { bar: T; }
+>foo : T
+
+        this.withFoo<T>().withBar<T>().bar;
+>this.withFoo<T>().withBar<T>().bar : T
+>this.withFoo<T>().withBar<T>() : Builder & { foo: T; } & { bar: T; }
+>this.withFoo<T>().withBar : <T>() => Builder & { foo: T; } & { bar: T; }
+>this.withFoo<T>() : this & { foo: T; }
+>this.withFoo : <T>() => this & { foo: T; }
+>this : this
+>withFoo : <T>() => this & { foo: T; }
+>withBar : <T>() => Builder & { foo: T; } & { bar: T; }
+>bar : T
+
+        return this.withFoo<T>().withBar<T>();
+>this.withFoo<T>().withBar<T>() : Builder & { foo: T; } & { bar: T; }
+>this.withFoo<T>().withBar : <T>() => Builder & { foo: T; } & { bar: T; }
+>this.withFoo<T>() : this & { foo: T; }
+>this.withFoo : <T>() => this & { foo: T; }
+>this : this
+>withFoo : <T>() => this & { foo: T; }
+>withBar : <T>() => Builder & { foo: T; } & { bar: T; }
+    }
+}
+
+declare var f: {foo: number};
+>f : { foo: number; }
+>foo : number
+
+new Builder().withFoo<number>().withBar<number>().foo;
+>new Builder().withFoo<number>().withBar<number>().foo : number
+>new Builder().withFoo<number>().withBar<number>() : Builder & { foo: number; } & { bar: number; }
+>new Builder().withFoo<number>().withBar : <T>() => Builder & { foo: number; } & { bar: T; }
+>new Builder().withFoo<number>() : Builder & { foo: number; }
+>new Builder().withFoo : <T>() => Builder & { foo: T; }
+>new Builder() : Builder
+>Builder : typeof Builder
+>withFoo : <T>() => Builder & { foo: T; }
+>withBar : <T>() => Builder & { foo: number; } & { bar: T; }
+>foo : number
+
+new Builder().withFoo<number>().withBar<number>().bar;
+>new Builder().withFoo<number>().withBar<number>().bar : number
+>new Builder().withFoo<number>().withBar<number>() : Builder & { foo: number; } & { bar: number; }
+>new Builder().withFoo<number>().withBar : <T>() => Builder & { foo: number; } & { bar: T; }
+>new Builder().withFoo<number>() : Builder & { foo: number; }
+>new Builder().withFoo : <T>() => Builder & { foo: T; }
+>new Builder() : Builder
+>Builder : typeof Builder
+>withFoo : <T>() => Builder & { foo: T; }
+>withBar : <T>() => Builder & { foo: number; } & { bar: T; }
+>bar : number
+
+f = new Builder().withFoo<number>().withBar<number>();
+>f = new Builder().withFoo<number>().withBar<number>() : Builder & { foo: number; } & { bar: number; }
+>f : { foo: number; }
+>new Builder().withFoo<number>().withBar<number>() : Builder & { foo: number; } & { bar: number; }
+>new Builder().withFoo<number>().withBar : <T>() => Builder & { foo: number; } & { bar: T; }
+>new Builder().withFoo<number>() : Builder & { foo: number; }
+>new Builder().withFoo : <T>() => Builder & { foo: T; }
+>new Builder() : Builder
+>Builder : typeof Builder
+>withFoo : <T>() => Builder & { foo: T; }
+>withBar : <T>() => Builder & { foo: number; } & { bar: T; }
+
+new Builder().withFooBar<number>().foo;
+>new Builder().withFooBar<number>().foo : number
+>new Builder().withFooBar<number>() : Builder & { foo: number; } & { bar: number; }
+>new Builder().withFooBar : <T>() => Builder & { foo: T; } & { bar: T; }
+>new Builder() : Builder
+>Builder : typeof Builder
+>withFooBar : <T>() => Builder & { foo: T; } & { bar: T; }
+>foo : number
+
+new Builder().withFooBar<number>().bar;
+>new Builder().withFooBar<number>().bar : number
+>new Builder().withFooBar<number>() : Builder & { foo: number; } & { bar: number; }
+>new Builder().withFooBar : <T>() => Builder & { foo: T; } & { bar: T; }
+>new Builder() : Builder
+>Builder : typeof Builder
+>withFooBar : <T>() => Builder & { foo: T; } & { bar: T; }
+>bar : number
+
+f = new Builder().withFooBar<number>();
+>f = new Builder().withFooBar<number>() : Builder & { foo: number; } & { bar: number; }
+>f : { foo: number; }
+>new Builder().withFooBar<number>() : Builder & { foo: number; } & { bar: number; }
+>new Builder().withFooBar : <T>() => Builder & { foo: T; } & { bar: T; }
+>new Builder() : Builder
+>Builder : typeof Builder
+>withFooBar : <T>() => Builder & { foo: T; } & { bar: T; }
+
diff --git a/tests/cases/compiler/chainedThisRefinements.ts b/tests/cases/compiler/chainedThisRefinements.ts
new file mode 100644
index 0000000000000..7dab042d628d2
--- /dev/null
+++ b/tests/cases/compiler/chainedThisRefinements.ts
@@ -0,0 +1,22 @@
+class Builder {
+    private _class: undefined;
+    withFoo<T>() {
+        return this as this & { foo: T }
+    }
+    withBar<T>() {
+        return this as this & { bar: T }
+    }
+    withFooBar<T>() {
+        this.withFoo<T>().withBar<T>().foo;
+        this.withFoo<T>().withBar<T>().bar;
+        return this.withFoo<T>().withBar<T>();
+    }
+}
+
+declare var f: {foo: number};
+new Builder().withFoo<number>().withBar<number>().foo;
+new Builder().withFoo<number>().withBar<number>().bar;
+f = new Builder().withFoo<number>().withBar<number>();
+new Builder().withFooBar<number>().foo;
+new Builder().withFooBar<number>().bar;
+f = new Builder().withFooBar<number>();