diff --git a/src/compiler/checker.ts b/src/compiler/checker.ts
index 8cacad8eb7e8a..0456ecce73a90 100644
--- a/src/compiler/checker.ts
+++ b/src/compiler/checker.ts
@@ -6558,6 +6558,12 @@ namespace ts {
             return mapper;
         }
 
+        function createReplacementMapper(source: Type, target: Type, baseMapper: TypeMapper) {
+            const mapper: TypeMapper = t => t === source ? target : baseMapper(t);
+            mapper.mappedTypes = baseMapper.mappedTypes;
+            return mapper;
+        }
+
         function cloneTypeParameter(typeParameter: TypeParameter): TypeParameter {
             const result = <TypeParameter>createType(TypeFlags.TypeParameter);
             result.symbol = typeParameter.symbol;
@@ -6656,10 +6662,7 @@ namespace ts {
                     if (typeVariable !== mappedTypeVariable) {
                         return mapType(mappedTypeVariable, t => {
                             if (isMappableType(t)) {
-                                const replacementMapper = createTypeMapper([typeVariable], [t]);
-                                const combinedMapper = mapper.mappedTypes && mapper.mappedTypes.length === 1 ? replacementMapper : combineTypeMappers(replacementMapper, mapper);
-                                combinedMapper.mappedTypes = mapper.mappedTypes;
-                                return instantiateMappedObjectType(type, combinedMapper);
+                                return instantiateMappedObjectType(type, createReplacementMapper(typeVariable, t, mapper));
                             }
                             return t;
                         });
diff --git a/tests/baselines/reference/mappedTypeWithCombinedTypeMappers.errors.txt b/tests/baselines/reference/mappedTypeWithCombinedTypeMappers.errors.txt
new file mode 100644
index 0000000000000..56837dd787e49
--- /dev/null
+++ b/tests/baselines/reference/mappedTypeWithCombinedTypeMappers.errors.txt
@@ -0,0 +1,25 @@
+tests/cases/compiler/mappedTypeWithCombinedTypeMappers.ts(18,7): error TS2322: Type 'string' is not assignable to type '{ important: boolean; }'.
+
+
+==== tests/cases/compiler/mappedTypeWithCombinedTypeMappers.ts (1 errors) ====
+    // Repro from #13351
+    
+    type Meta<T, A> = {
+        readonly[P in keyof T]: {
+            value: T[P];
+            also: A;
+            readonly children: Meta<T[P], A>;
+        };
+    }
+    
+    interface Input {
+        x: string;
+        y: number;
+    }
+    
+    declare const output: Meta<Input, boolean>;
+    
+    const shouldFail: { important: boolean } = output.x.children;
+          ~~~~~~~~~~
+!!! error TS2322: Type 'string' is not assignable to type '{ important: boolean; }'.
+    
\ No newline at end of file
diff --git a/tests/baselines/reference/mappedTypeWithCombinedTypeMappers.js b/tests/baselines/reference/mappedTypeWithCombinedTypeMappers.js
new file mode 100644
index 0000000000000..a445f2eebc5ac
--- /dev/null
+++ b/tests/baselines/reference/mappedTypeWithCombinedTypeMappers.js
@@ -0,0 +1,24 @@
+//// [mappedTypeWithCombinedTypeMappers.ts]
+// Repro from #13351
+
+type Meta<T, A> = {
+    readonly[P in keyof T]: {
+        value: T[P];
+        also: A;
+        readonly children: Meta<T[P], A>;
+    };
+}
+
+interface Input {
+    x: string;
+    y: number;
+}
+
+declare const output: Meta<Input, boolean>;
+
+const shouldFail: { important: boolean } = output.x.children;
+
+
+//// [mappedTypeWithCombinedTypeMappers.js]
+// Repro from #13351
+var shouldFail = output.x.children;
diff --git a/tests/cases/compiler/mappedTypeWithCombinedTypeMappers.ts b/tests/cases/compiler/mappedTypeWithCombinedTypeMappers.ts
new file mode 100644
index 0000000000000..9c6d8479b2e69
--- /dev/null
+++ b/tests/cases/compiler/mappedTypeWithCombinedTypeMappers.ts
@@ -0,0 +1,18 @@
+// Repro from #13351
+
+type Meta<T, A> = {
+    readonly[P in keyof T]: {
+        value: T[P];
+        also: A;
+        readonly children: Meta<T[P], A>;
+    };
+}
+
+interface Input {
+    x: string;
+    y: number;
+}
+
+declare const output: Meta<Input, boolean>;
+
+const shouldFail: { important: boolean } = output.x.children;