diff --git a/llvm/lib/Target/AMDGPU/SIWholeQuadMode.cpp b/llvm/lib/Target/AMDGPU/SIWholeQuadMode.cpp
index 5b4c44302fa62..913942dda19d9 100644
--- a/llvm/lib/Target/AMDGPU/SIWholeQuadMode.cpp
+++ b/llvm/lib/Target/AMDGPU/SIWholeQuadMode.cpp
@@ -225,7 +225,7 @@ class SIWholeQuadMode : public MachineFunctionPass {
   void lowerCopyInstrs();
   void lowerKillInstrs(bool IsWQM);
   void lowerInitExec(MachineInstr &MI);
-  void lowerInitExecInstrs();
+  MachineBasicBlock::iterator lowerInitExecInstrs(MachineBasicBlock &Entry);
 
 public:
   static char ID;
@@ -1648,9 +1648,23 @@ void SIWholeQuadMode::lowerInitExec(MachineInstr &MI) {
   LIS->createAndComputeVirtRegInterval(CountReg);
 }
 
-void SIWholeQuadMode::lowerInitExecInstrs() {
-  for (MachineInstr *MI : InitExecInstrs)
+/// Lower INIT_EXEC instructions. Return a suitable insert point in \p Entry
+/// for instructions that depend on EXEC.
+MachineBasicBlock::iterator
+SIWholeQuadMode::lowerInitExecInstrs(MachineBasicBlock &Entry) {
+  MachineBasicBlock::iterator InsertPt = Entry.getFirstNonPHI();
+
+  for (MachineInstr *MI : InitExecInstrs) {
+    // Try to handle undefined cases gracefully:
+    // - multiple INIT_EXEC instructions
+    // - INIT_EXEC instructions not in the entry block
+    if (MI->getParent() == &Entry)
+      InsertPt = std::next(MI->getIterator());
+
     lowerInitExec(*MI);
+  }
+
+  return InsertPt;
 }
 
 bool SIWholeQuadMode::runOnMachineFunction(MachineFunction &MF) {
@@ -1701,19 +1715,16 @@ bool SIWholeQuadMode::runOnMachineFunction(MachineFunction &MF) {
 
   LiveMaskReg = Exec;
 
+  MachineBasicBlock &Entry = MF.front();
+  MachineBasicBlock::iterator EntryMI = lowerInitExecInstrs(Entry);
+
   // Shader is simple does not need any state changes or any complex lowering
   if (!(GlobalFlags & (StateWQM | StateStrict)) && LowerToCopyInstrs.empty() &&
       LowerToMovInstrs.empty() && KillInstrs.empty()) {
-    lowerInitExecInstrs();
     lowerLiveMaskQueries();
     return !InitExecInstrs.empty() || !LiveMaskQueries.empty();
   }
 
-  lowerInitExecInstrs();
-
-  MachineBasicBlock &Entry = MF.front();
-  MachineBasicBlock::iterator EntryMI = Entry.getFirstNonPHI();
-
   // Store a copy of the original live mask when required
   if (NeedsLiveMask || (GlobalFlags & StateWQM)) {
     LiveMaskReg = MRI->createVirtualRegister(TRI->getBoolRC());
diff --git a/llvm/test/CodeGen/AMDGPU/wqm.ll b/llvm/test/CodeGen/AMDGPU/wqm.ll
index 6fcf5067b0225..3bf6c104a0254 100644
--- a/llvm/test/CodeGen/AMDGPU/wqm.ll
+++ b/llvm/test/CodeGen/AMDGPU/wqm.ll
@@ -3395,6 +3395,52 @@ main_body:
   ret void
 }
 
+; Test the interaction between wqm and llvm.amdgcn.init.exec.
+define amdgpu_gs void @wqm_init_exec() {
+; GFX9-W64-LABEL: wqm_init_exec:
+; GFX9-W64:       ; %bb.0: ; %bb
+; GFX9-W64-NEXT:    s_mov_b64 exec, -1
+; GFX9-W64-NEXT:    s_mov_b32 s0, 0
+; GFX9-W64-NEXT:    v_mov_b32_e32 v0, 0
+; GFX9-W64-NEXT:    s_mov_b32 s1, s0
+; GFX9-W64-NEXT:    s_mov_b32 s2, s0
+; GFX9-W64-NEXT:    s_mov_b32 s3, s0
+; GFX9-W64-NEXT:    v_mov_b32_e32 v1, v0
+; GFX9-W64-NEXT:    v_mov_b32_e32 v2, v0
+; GFX9-W64-NEXT:    v_mov_b32_e32 v3, v0
+; GFX9-W64-NEXT:    buffer_store_dwordx4 v[0:3], off, s[0:3], 0
+; GFX9-W64-NEXT:    s_wqm_b64 exec, exec
+; GFX9-W64-NEXT:    ; kill: def $sgpr0 killed $sgpr0 killed $exec
+; GFX9-W64-NEXT:    v_mov_b32_e32 v1, s0
+; GFX9-W64-NEXT:    ds_write_b32 v0, v1
+; GFX9-W64-NEXT:    s_endpgm
+;
+; GFX10-W32-LABEL: wqm_init_exec:
+; GFX10-W32:       ; %bb.0: ; %bb
+; GFX10-W32-NEXT:    s_mov_b32 exec_lo, -1
+; GFX10-W32-NEXT:    s_mov_b32 s1, exec_lo
+; GFX10-W32-NEXT:    v_mov_b32_e32 v0, 0
+; GFX10-W32-NEXT:    s_mov_b32 s0, 0
+; GFX10-W32-NEXT:    s_wqm_b32 exec_lo, exec_lo
+; GFX10-W32-NEXT:    s_mov_b32 s2, s0
+; GFX10-W32-NEXT:    s_and_b32 exec_lo, exec_lo, s1
+; GFX10-W32-NEXT:    v_mov_b32_e32 v1, v0
+; GFX10-W32-NEXT:    v_mov_b32_e32 v2, v0
+; GFX10-W32-NEXT:    v_mov_b32_e32 v3, v0
+; GFX10-W32-NEXT:    v_mov_b32_e32 v4, s0
+; GFX10-W32-NEXT:    s_mov_b32 s1, s0
+; GFX10-W32-NEXT:    s_mov_b32 s3, s0
+; GFX10-W32-NEXT:    buffer_store_dwordx4 v[0:3], off, s[0:3], 0
+; GFX10-W32-NEXT:    ds_write_b32 v0, v4
+; GFX10-W32-NEXT:    s_endpgm
+bb:
+  call void @llvm.amdgcn.init.exec(i64 -1)
+  call void @llvm.amdgcn.raw.buffer.store.v4f32(<4 x float> zeroinitializer, <4 x i32> zeroinitializer, i32 0, i32 0, i32 0)
+  %i = call i32 @llvm.amdgcn.wqm.i32(i32 0)
+  store i32 %i, i32 addrspace(3)* null, align 4
+  ret void
+}
+
 declare void @llvm.amdgcn.exp.f32(i32, i32, float, float, float, float, i1, i1) #1
 declare void @llvm.amdgcn.image.store.1d.v4f32.i32(<4 x float>, i32, i32, <8 x i32>, i32, i32) #1