diff --git a/mlir/CMakeLists.txt b/mlir/CMakeLists.txt
index 9e786154a2b40..3b04244d23d37 100644
--- a/mlir/CMakeLists.txt
+++ b/mlir/CMakeLists.txt
@@ -178,6 +178,8 @@ set(MLIR_BINDINGS_PYTHON_NB_DOMAIN "mlir"
   CACHE STRING "nanobind domain for MLIR python bindings.")
 set(MLIR_ENABLE_BINDINGS_PYTHON 0 CACHE BOOL
        "Enables building of Python bindings.")
+set(MLIR_BINDINGS_PYTHON_INSTALL_PREFIX "python_packages/mlir_core/mlir" CACHE STRING
+       "Prefix under install directory to place python bindings")
 set(MLIR_DETECT_PYTHON_ENV_PRIME_SEARCH 1 CACHE BOOL
        "Prime the python detection by searching for a full 'Development' \
        component first (temporary while diagnosing environment specific Python \
diff --git a/mlir/python/CMakeLists.txt b/mlir/python/CMakeLists.txt
index fb115a5f43423..bf6627904f866 100644
--- a/mlir/python/CMakeLists.txt
+++ b/mlir/python/CMakeLists.txt
@@ -356,7 +356,7 @@ declare_mlir_dialect_python_bindings(
   ADD_TO_PARENT MLIRPythonSources.Dialects
   ROOT_DIR "${CMAKE_CURRENT_SOURCE_DIR}/mlir"
   TD_FILE dialects/EmitC.td
-  SOURCES 
+  SOURCES
     dialects/emitc.py
   DIALECT_NAME emitc)
 
@@ -764,7 +764,7 @@ endif()
 
 add_mlir_python_common_capi_library(MLIRPythonCAPI
   INSTALL_COMPONENT MLIRPythonModules
-  INSTALL_DESTINATION python_packages/mlir_core/mlir/_mlir_libs
+  INSTALL_DESTINATION "${MLIR_BINDINGS_PYTHON_INSTALL_PREFIX}/_mlir_libs"
   OUTPUT_DIRECTORY "${MLIR_BINARY_DIR}/python_packages/mlir_core/mlir/_mlir_libs"
   RELATIVE_INSTALL_ROOT "../../../.."
   DECLARED_HEADERS
@@ -795,7 +795,7 @@ endif()
 
 add_mlir_python_modules(MLIRPythonModules
   ROOT_PREFIX "${MLIR_BINARY_DIR}/python_packages/mlir_core/mlir"
-  INSTALL_PREFIX "python_packages/mlir_core/mlir"
+  INSTALL_PREFIX "${MLIR_BINDINGS_PYTHON_INSTALL_PREFIX}"
   DECLARED_SOURCES
     MLIRPythonSources
     MLIRPythonExtension.RegisterEverything
diff --git a/mlir/python/pyproject.toml b/mlir/python/pyproject.toml
new file mode 100644
index 0000000000000..4abaa2416826d
--- /dev/null
+++ b/mlir/python/pyproject.toml
@@ -0,0 +1,43 @@
+# Part of the LLVM Project, under the Apache License v2.0 with LLVM Exceptions.
+# See https://llvm.org/LICENSE.txt for license information.
+# SPDX-License-Identifier: Apache-2.0 WITH LLVM-exception
+# Copyright (c) 2025.
+
+[project]
+name = "mlir-python-bindings"
+version = "0.0.1"
+requires-python = ">=3.8,<=3.13"
+[project.urls]
+Homepage = "https://github.com/llvm/llvm-project"
+Discussions = "https://discourse.llvm.org/"
+"Issue Tracker" = "https://github.com/llvm/llvm-project/issues?q=is%3Aissue%20state%3Aopen%20label%3Amlir%3Apython%20"
+"Source Code" = "https://github.com/llvm/llvm-project/tree/main/mlir/python"
+
+[build-system]
+requires = [
+    "scikit-build-core==0.10.7",
+    "typing_extensions==4.12.2",
+    "nanobind>=2.4, <3.0",
+    "numpy>=1.19.5, <=2.1.2",
+    "pybind11>=2.10.0, <=2.13.6",
+    "PyYAML>=5.4.0, <=6.0.1",
+    'ml_dtypes>=0.1.0, <=0.6.0; python_version<"3.13"',
+    'ml_dtypes>=0.5.0, <=0.6.0; python_version>="3.13"'
+]
+build-backend = "scikit_build_core.build"
+
+[tool.scikit-build]
+minimum-version = "0.10"
+build-dir = "../../build"
+cmake.source-dir = "../../llvm"
+wheel.exclude = ["bin", "include", "lib", "src", "share"]
+build.targets = ["MLIRPythonModules"]
+
+[tool.scikit-build.cmake.define]
+CMAKE_C_COMPILER_LAUNCHER = { env = "CMAKE_C_COMPILER_LAUNCHER", default = "" }
+CMAKE_CXX_COMPILER_LAUNCHER = { env = "CMAKE_CXX_COMPILER_LAUNCHER", default = "" }
+CMAKE_CXX_VISIBILITY_PRESET = "hidden"
+CMAKE_VERBOSE_MAKEFILE = "ON"
+LLVM_ENABLE_PROJECTS = "mlir"
+MLIR_ENABLE_BINDINGS_PYTHON = "ON"
+MLIR_BINDINGS_PYTHON_INSTALL_PREFIX = "mlir"