diff --git a/packages/node/src/tracing/index.ts b/packages/node/src/tracing/index.ts
index 15c4e2889b3f..2b4be9d41e70 100644
--- a/packages/node/src/tracing/index.ts
+++ b/packages/node/src/tracing/index.ts
@@ -1,3 +1,4 @@
+import type { LazyLoadedIntegration } from '@sentry-internal/tracing';
 import { lazyLoadedNodePerformanceMonitoringIntegrations } from '@sentry-internal/tracing';
 import type { Integration } from '@sentry/types';
 import { logger } from '@sentry/utils';
@@ -14,11 +15,12 @@ export function autoDiscoverNodePerformanceMonitoringIntegrations(): Integration
         return undefined;
       }
     })
-    .filter(integration => !!integration) as Integration[];
+    .filter(integration => !!integration) as LazyLoadedIntegration[];
 
   if (loadedIntegrations.length === 0) {
     logger.warn('Performance monitoring integrations could not be automatically loaded.');
   }
 
-  return loadedIntegrations;
+  // Only return integrations where their dependencies loaded successfully.
+  return loadedIntegrations.filter(integration => !!integration.loadDependency());
 }
diff --git a/packages/tracing-internal/src/index.ts b/packages/tracing-internal/src/index.ts
index c4e17c25294f..da9b94aac666 100644
--- a/packages/tracing-internal/src/index.ts
+++ b/packages/tracing-internal/src/index.ts
@@ -10,6 +10,7 @@ export {
   Prisma,
   lazyLoadedNodePerformanceMonitoringIntegrations,
 } from './node';
+export type { LazyLoadedIntegration } from './node';
 
 export {
   BrowserTracing,
diff --git a/packages/tracing-internal/src/node/integrations/apollo.ts b/packages/tracing-internal/src/node/integrations/apollo.ts
index 3a076444af5e..5a9c0219a00c 100644
--- a/packages/tracing-internal/src/node/integrations/apollo.ts
+++ b/packages/tracing-internal/src/node/integrations/apollo.ts
@@ -1,7 +1,8 @@
 import type { Hub } from '@sentry/core';
-import type { EventProcessor, Integration } from '@sentry/types';
+import type { EventProcessor } from '@sentry/types';
 import { arrayify, fill, isThenable, loadModule, logger } from '@sentry/utils';
 
+import type { LazyLoadedIntegration } from './lazy';
 import { shouldDisableAutoInstrumentation } from './utils/node-utils';
 
 interface ApolloOptions {
@@ -16,8 +17,24 @@ type ApolloModelResolvers = {
   [key: string]: ApolloResolverGroup;
 };
 
+type GraphQLModule = {
+  GraphQLFactory: {
+    prototype: {
+      create: (resolvers: ApolloModelResolvers[]) => unknown;
+    };
+  };
+};
+
+type ApolloModule = {
+  ApolloServerBase: {
+    prototype: {
+      constructSchema: (config: unknown) => unknown;
+    };
+  };
+};
+
 /** Tracing integration for Apollo */
-export class Apollo implements Integration {
+export class Apollo implements LazyLoadedIntegration<GraphQLModule & ApolloModule> {
   /**
    * @inheritDoc
    */
@@ -30,6 +47,8 @@ export class Apollo implements Integration {
 
   private readonly _useNest: boolean;
 
+  private _module?: GraphQLModule & ApolloModule;
+
   /**
    * @inheritDoc
    */
@@ -41,6 +60,17 @@ export class Apollo implements Integration {
     this._useNest = !!options.useNestjs;
   }
 
+  /** @inheritdoc */
+  public loadDependency(): (GraphQLModule & ApolloModule) | undefined {
+    if (this._useNest) {
+      this._module = this._module || loadModule('@nestjs/graphql');
+    } else {
+      this._module = this._module || loadModule('apollo-server-core');
+    }
+
+    return this._module;
+  }
+
   /**
    * @inheritDoc
    */
@@ -51,13 +81,7 @@ export class Apollo implements Integration {
     }
 
     if (this._useNest) {
-      const pkg = loadModule<{
-        GraphQLFactory: {
-          prototype: {
-            create: (resolvers: ApolloModelResolvers[]) => unknown;
-          };
-        };
-      }>('@nestjs/graphql');
+      const pkg = this.loadDependency();
 
       if (!pkg) {
         __DEBUG_BUILD__ && logger.error('Apollo-NestJS Integration was unable to require @nestjs/graphql package.');
@@ -90,13 +114,7 @@ export class Apollo implements Integration {
         },
       );
     } else {
-      const pkg = loadModule<{
-        ApolloServerBase: {
-          prototype: {
-            constructSchema: (config: unknown) => unknown;
-          };
-        };
-      }>('apollo-server-core');
+      const pkg = this.loadDependency();
 
       if (!pkg) {
         __DEBUG_BUILD__ && logger.error('Apollo Integration was unable to require apollo-server-core package.');
diff --git a/packages/tracing-internal/src/node/integrations/graphql.ts b/packages/tracing-internal/src/node/integrations/graphql.ts
index 12f04b7c1e57..027419ae8ce8 100644
--- a/packages/tracing-internal/src/node/integrations/graphql.ts
+++ b/packages/tracing-internal/src/node/integrations/graphql.ts
@@ -1,11 +1,16 @@
 import type { Hub } from '@sentry/core';
-import type { EventProcessor, Integration } from '@sentry/types';
+import type { EventProcessor } from '@sentry/types';
 import { fill, isThenable, loadModule, logger } from '@sentry/utils';
 
+import type { LazyLoadedIntegration } from './lazy';
 import { shouldDisableAutoInstrumentation } from './utils/node-utils';
 
+type GraphQLModule = {
+  [method: string]: (...args: unknown[]) => unknown;
+};
+
 /** Tracing integration for graphql package */
-export class GraphQL implements Integration {
+export class GraphQL implements LazyLoadedIntegration<GraphQLModule> {
   /**
    * @inheritDoc
    */
@@ -16,6 +21,13 @@ export class GraphQL implements Integration {
    */
   public name: string = GraphQL.id;
 
+  private _module?: GraphQLModule;
+
+  /** @inheritdoc */
+  public loadDependency(): GraphQLModule | undefined {
+    return (this._module = this._module || loadModule('graphql/execution/execute.js'));
+  }
+
   /**
    * @inheritDoc
    */
@@ -25,9 +37,7 @@ export class GraphQL implements Integration {
       return;
     }
 
-    const pkg = loadModule<{
-      [method: string]: (...args: unknown[]) => unknown;
-    }>('graphql/execution/execute.js');
+    const pkg = this.loadDependency();
 
     if (!pkg) {
       __DEBUG_BUILD__ && logger.error('GraphQL Integration was unable to require graphql/execution package.');
diff --git a/packages/tracing-internal/src/node/integrations/lazy.ts b/packages/tracing-internal/src/node/integrations/lazy.ts
index f53ff756cd48..635f5b082bee 100644
--- a/packages/tracing-internal/src/node/integrations/lazy.ts
+++ b/packages/tracing-internal/src/node/integrations/lazy.ts
@@ -1,46 +1,55 @@
 import type { Integration, IntegrationClass } from '@sentry/types';
 import { dynamicRequire } from '@sentry/utils';
 
-export const lazyLoadedNodePerformanceMonitoringIntegrations: (() => Integration)[] = [
+export interface LazyLoadedIntegration<T = object> extends Integration {
+  /**
+   * Loads the integration's dependency and caches it so it doesn't have to be loaded again.
+   *
+   * If this returns undefined, the dependency could not be loaded.
+   */
+  loadDependency(): T | undefined;
+}
+
+export const lazyLoadedNodePerformanceMonitoringIntegrations: (() => LazyLoadedIntegration)[] = [
   () => {
     const integration = dynamicRequire(module, './apollo') as {
-      Apollo: IntegrationClass<Integration>;
+      Apollo: IntegrationClass<LazyLoadedIntegration>;
     };
     return new integration.Apollo();
   },
   () => {
     const integration = dynamicRequire(module, './apollo') as {
-      Apollo: IntegrationClass<Integration>;
+      Apollo: IntegrationClass<LazyLoadedIntegration>;
     };
     return new integration.Apollo({ useNestjs: true });
   },
   () => {
     const integration = dynamicRequire(module, './graphql') as {
-      GraphQL: IntegrationClass<Integration>;
+      GraphQL: IntegrationClass<LazyLoadedIntegration>;
     };
     return new integration.GraphQL();
   },
   () => {
     const integration = dynamicRequire(module, './mongo') as {
-      Mongo: IntegrationClass<Integration>;
+      Mongo: IntegrationClass<LazyLoadedIntegration>;
     };
     return new integration.Mongo();
   },
   () => {
     const integration = dynamicRequire(module, './mongo') as {
-      Mongo: IntegrationClass<Integration>;
+      Mongo: IntegrationClass<LazyLoadedIntegration>;
     };
     return new integration.Mongo({ mongoose: true });
   },
   () => {
     const integration = dynamicRequire(module, './mysql') as {
-      Mysql: IntegrationClass<Integration>;
+      Mysql: IntegrationClass<LazyLoadedIntegration>;
     };
     return new integration.Mysql();
   },
   () => {
     const integration = dynamicRequire(module, './postgres') as {
-      Postgres: IntegrationClass<Integration>;
+      Postgres: IntegrationClass<LazyLoadedIntegration>;
     };
     return new integration.Postgres();
   },
diff --git a/packages/tracing-internal/src/node/integrations/mongo.ts b/packages/tracing-internal/src/node/integrations/mongo.ts
index 37335358c82e..5364f234df8d 100644
--- a/packages/tracing-internal/src/node/integrations/mongo.ts
+++ b/packages/tracing-internal/src/node/integrations/mongo.ts
@@ -1,7 +1,8 @@
 import type { Hub } from '@sentry/core';
-import type { EventProcessor, Integration, SpanContext } from '@sentry/types';
+import type { EventProcessor, SpanContext } from '@sentry/types';
 import { fill, isThenable, loadModule, logger } from '@sentry/utils';
 
+import type { LazyLoadedIntegration } from './lazy';
 import { shouldDisableAutoInstrumentation } from './utils/node-utils';
 
 // This allows us to use the same array for both defaults options and the type itself.
@@ -98,8 +99,10 @@ function isCursor(maybeCursor: MongoCursor): maybeCursor is MongoCursor {
   return maybeCursor && typeof maybeCursor === 'object' && maybeCursor.once && typeof maybeCursor.once === 'function';
 }
 
+type MongoModule = { Collection: MongoCollection };
+
 /** Tracing integration for mongo package */
-export class Mongo implements Integration {
+export class Mongo implements LazyLoadedIntegration<MongoModule> {
   /**
    * @inheritDoc
    */
@@ -114,6 +117,8 @@ export class Mongo implements Integration {
   private _describeOperations?: boolean | Operation[];
   private _useMongoose: boolean;
 
+  private _module?: MongoModule;
+
   /**
    * @inheritDoc
    */
@@ -123,6 +128,12 @@ export class Mongo implements Integration {
     this._useMongoose = !!options.useMongoose;
   }
 
+  /** @inheritdoc */
+  public loadDependency(): MongoModule | undefined {
+    const moduleName = this._useMongoose ? 'mongoose' : 'mongodb';
+    return (this._module = this._module || loadModule(moduleName));
+  }
+
   /**
    * @inheritDoc
    */
@@ -132,10 +143,10 @@ export class Mongo implements Integration {
       return;
     }
 
-    const moduleName = this._useMongoose ? 'mongoose' : 'mongodb';
-    const pkg = loadModule<{ Collection: MongoCollection }>(moduleName);
+    const pkg = this.loadDependency();
 
     if (!pkg) {
+      const moduleName = this._useMongoose ? 'mongoose' : 'mongodb';
       __DEBUG_BUILD__ && logger.error(`Mongo Integration was unable to require \`${moduleName}\` package.`);
       return;
     }
diff --git a/packages/tracing-internal/src/node/integrations/mysql.ts b/packages/tracing-internal/src/node/integrations/mysql.ts
index 6e6a80ac59a6..529e3b859bc2 100644
--- a/packages/tracing-internal/src/node/integrations/mysql.ts
+++ b/packages/tracing-internal/src/node/integrations/mysql.ts
@@ -1,7 +1,8 @@
 import type { Hub } from '@sentry/core';
-import type { EventProcessor, Integration } from '@sentry/types';
+import type { EventProcessor } from '@sentry/types';
 import { fill, loadModule, logger } from '@sentry/utils';
 
+import type { LazyLoadedIntegration } from './lazy';
 import { shouldDisableAutoInstrumentation } from './utils/node-utils';
 
 interface MysqlConnection {
@@ -9,7 +10,7 @@ interface MysqlConnection {
 }
 
 /** Tracing integration for node-mysql package */
-export class Mysql implements Integration {
+export class Mysql implements LazyLoadedIntegration<MysqlConnection> {
   /**
    * @inheritDoc
    */
@@ -20,6 +21,13 @@ export class Mysql implements Integration {
    */
   public name: string = Mysql.id;
 
+  private _module?: MysqlConnection;
+
+  /** @inheritdoc */
+  public loadDependency(): MysqlConnection | undefined {
+    return (this._module = this._module || loadModule('mysql/lib/Connection.js'));
+  }
+
   /**
    * @inheritDoc
    */
@@ -29,7 +37,7 @@ export class Mysql implements Integration {
       return;
     }
 
-    const pkg = loadModule<MysqlConnection>('mysql/lib/Connection.js');
+    const pkg = this.loadDependency();
 
     if (!pkg) {
       __DEBUG_BUILD__ && logger.error('Mysql Integration was unable to require `mysql` package.');
diff --git a/packages/tracing-internal/src/node/integrations/postgres.ts b/packages/tracing-internal/src/node/integrations/postgres.ts
index 41ad31b20660..be7e299cf6aa 100644
--- a/packages/tracing-internal/src/node/integrations/postgres.ts
+++ b/packages/tracing-internal/src/node/integrations/postgres.ts
@@ -1,7 +1,8 @@
 import type { Hub } from '@sentry/core';
-import type { EventProcessor, Integration } from '@sentry/types';
+import type { EventProcessor } from '@sentry/types';
 import { fill, isThenable, loadModule, logger } from '@sentry/utils';
 
+import type { LazyLoadedIntegration } from './lazy';
 import { shouldDisableAutoInstrumentation } from './utils/node-utils';
 
 interface PgClient {
@@ -14,8 +15,10 @@ interface PgOptions {
   usePgNative?: boolean;
 }
 
+type PGModule = { Client: PgClient; native: { Client: PgClient } };
+
 /** Tracing integration for node-postgres package */
-export class Postgres implements Integration {
+export class Postgres implements LazyLoadedIntegration<PGModule> {
   /**
    * @inheritDoc
    */
@@ -28,10 +31,17 @@ export class Postgres implements Integration {
 
   private _usePgNative: boolean;
 
+  private _module?: PGModule;
+
   public constructor(options: PgOptions = {}) {
     this._usePgNative = !!options.usePgNative;
   }
 
+  /** @inheritdoc */
+  public loadDependency(): PGModule | undefined {
+    return (this._module = this._module || loadModule('pg'));
+  }
+
   /**
    * @inheritDoc
    */
@@ -41,7 +51,7 @@ export class Postgres implements Integration {
       return;
     }
 
-    const pkg = loadModule<{ Client: PgClient; native: { Client: PgClient } }>('pg');
+    const pkg = this.loadDependency();
 
     if (!pkg) {
       __DEBUG_BUILD__ && logger.error('Postgres Integration was unable to require `pg` package.');