diff --git a/packages/replay/src/integration.ts b/packages/replay/src/integration.ts
index b68ddd7f11fa..449c19ec9f00 100644
--- a/packages/replay/src/integration.ts
+++ b/packages/replay/src/integration.ts
@@ -120,7 +120,7 @@ Sentry.init({ replaysOnErrorSampleRate: ${errorSampleRate} })`,
         : `${this.recordingOptions.blockSelector},${MEDIA_SELECTORS}`;
     }
 
-    if (isBrowser() && this._isInitialized) {
+    if (this._isInitialized && isBrowser()) {
       throw new Error('Multiple Sentry Session Replay instances are not supported');
     }
 
diff --git a/packages/replay/src/util/isBrowser.ts b/packages/replay/src/util/isBrowser.ts
index fb87bc3c7e55..3ad78dce93a5 100644
--- a/packages/replay/src/util/isBrowser.ts
+++ b/packages/replay/src/util/isBrowser.ts
@@ -2,5 +2,12 @@ import { isNodeEnv } from '@sentry/utils';
 
 export function isBrowser(): boolean {
   // eslint-disable-next-line no-restricted-globals
-  return typeof window !== 'undefined' && !isNodeEnv();
+  return typeof window !== 'undefined' && (!isNodeEnv() || isElectronNodeRenderer());
+}
+
+type ElectronProcess = { type?: string };
+
+// Electron renderers with nodeIntegration enabled are detected as Node.js so we specifically test for them
+function isElectronNodeRenderer(): boolean {
+  return typeof process !== 'undefined' && (process as ElectronProcess).type === 'renderer';
 }