diff --git a/dev-packages/e2e-tests/test-applications/node-exports-test-app/scripts/consistentExports.ts b/dev-packages/e2e-tests/test-applications/node-exports-test-app/scripts/consistentExports.ts
index 8c3f3ee0242d..ae31ee00a6dc 100644
--- a/dev-packages/e2e-tests/test-applications/node-exports-test-app/scripts/consistentExports.ts
+++ b/dev-packages/e2e-tests/test-applications/node-exports-test-app/scripts/consistentExports.ts
@@ -58,8 +58,6 @@ const DEPENDENTS: Dependent[] = [
     ignoreExports: [
       // not supported in bun:
       'NodeClient',
-      // legacy, to be removed...
-      'makeMain',
     ],
   },
   {
@@ -79,8 +77,6 @@ const DEPENDENTS: Dependent[] = [
     compareWith: nodeExports,
     exports: Object.keys(SentryAWS),
     ignoreExports: [
-      // legacy, to be removed...
-      'makeMain',
       // Not needed for Serverless
       'setupFastifyErrorHandler',
     ],
@@ -90,8 +86,6 @@ const DEPENDENTS: Dependent[] = [
     compareWith: nodeExports,
     exports: Object.keys(SentryGoogleCloud),
     ignoreExports: [
-      // legacy, to be removed...
-      'makeMain',
       // Not needed for Serverless
       'setupFastifyErrorHandler',
     ],
diff --git a/packages/astro/src/index.types.ts b/packages/astro/src/index.types.ts
index dad62a288d53..e5fe8fd965b4 100644
--- a/packages/astro/src/index.types.ts
+++ b/packages/astro/src/index.types.ts
@@ -22,8 +22,6 @@ export declare const defaultStackParser: StackParser;
 export declare function close(timeout?: number | undefined): PromiseLike<boolean>;
 export declare function flush(timeout?: number | undefined): PromiseLike<boolean>;
 
-// eslint-disable-next-line deprecation/deprecation
-export declare const makeMain: typeof clientSdk.makeMain;
 // eslint-disable-next-line deprecation/deprecation
 export declare const getCurrentHub: typeof clientSdk.getCurrentHub;
 export declare const getClient: typeof clientSdk.getClient;
diff --git a/packages/browser/src/exports.ts b/packages/browser/src/exports.ts
index 07fe2eda1c8c..8d581eaeda21 100644
--- a/packages/browser/src/exports.ts
+++ b/packages/browser/src/exports.ts
@@ -37,8 +37,6 @@ export {
   getIsolationScope,
   getGlobalScope,
   Hub,
-  // eslint-disable-next-line deprecation/deprecation
-  makeMain,
   setCurrentClient,
   Scope,
   continueTrace,
diff --git a/packages/core/src/hub.ts b/packages/core/src/hub.ts
index 39e9f7de1ec1..4c6cecf6858b 100644
--- a/packages/core/src/hub.ts
+++ b/packages/core/src/hub.ts
@@ -529,18 +529,6 @@ export class Hub implements HubInterface {
   }
 }
 
-/**
- * Replaces the current main hub with the passed one on the global object
- *
- * @returns The old replaced hub
- *
- * @deprecated Use `setCurrentClient()` instead.
- */
-export function makeMain(hub: HubInterface): HubInterface {
-  // noop!
-  return hub;
-}
-
 /**
  * Returns the default hub instance.
  *
diff --git a/packages/core/src/index.ts b/packages/core/src/index.ts
index c384701319ef..3a5cab6986b3 100644
--- a/packages/core/src/index.ts
+++ b/packages/core/src/index.ts
@@ -33,8 +33,6 @@ export {
   // eslint-disable-next-line deprecation/deprecation
   getCurrentHub,
   Hub,
-  // eslint-disable-next-line deprecation/deprecation
-  makeMain,
   getGlobalHub,
   getDefaultCurrentScope,
   getDefaultIsolationScope,
diff --git a/packages/node/src/index.ts b/packages/node/src/index.ts
index 0184c14e730e..66772bd034e1 100644
--- a/packages/node/src/index.ts
+++ b/packages/node/src/index.ts
@@ -40,8 +40,6 @@ export {
   getGlobalScope,
   getIsolationScope,
   Hub,
-  // eslint-disable-next-line deprecation/deprecation
-  makeMain,
   setCurrentClient,
   Scope,
   SDK_VERSION,
diff --git a/packages/node/test/integrations/http.test.ts b/packages/node/test/integrations/http.test.ts
index 3b1fa4904f04..e4ce93934ed4 100644
--- a/packages/node/test/integrations/http.test.ts
+++ b/packages/node/test/integrations/http.test.ts
@@ -1,6 +1,6 @@
 import * as http from 'http';
 import * as https from 'https';
-import { SEMANTIC_ATTRIBUTE_SENTRY_SOURCE, getSpanDescendants, makeMain, startSpan } from '@sentry/core';
+import { SEMANTIC_ATTRIBUTE_SENTRY_SOURCE, getSpanDescendants, startSpan } from '@sentry/core';
 import { getCurrentHub, getIsolationScope, setCurrentClient } from '@sentry/core';
 import { Transaction } from '@sentry/core';
 import { getCurrentScope, setUser, spanToJSON, startInactiveSpan } from '@sentry/core';
@@ -346,8 +346,6 @@ describe('tracing', () => {
       client.init();
       // eslint-disable-next-line deprecation/deprecation
       const hub = getCurrentHub();
-      // eslint-disable-next-line deprecation/deprecation
-      makeMain(hub);
 
       return hub;
     }
diff --git a/packages/remix/src/index.types.ts b/packages/remix/src/index.types.ts
index a4c619401d9d..cbbf17998188 100644
--- a/packages/remix/src/index.types.ts
+++ b/packages/remix/src/index.types.ts
@@ -27,8 +27,6 @@ export declare const defaultStackParser: StackParser;
 // methods from `@sentry/core`.
 declare const runtime: 'client' | 'server';
 
-// eslint-disable-next-line deprecation/deprecation
-export declare const makeMain: typeof clientSdk.makeMain;
 // eslint-disable-next-line deprecation/deprecation
 export declare const getCurrentHub: typeof clientSdk.getCurrentHub;
 export declare const getClient: typeof clientSdk.getClient;