diff --git a/dev-packages/node-integration-tests/suites/anr/stop-and-start.js b/dev-packages/node-integration-tests/suites/anr/stop-and-start.js
new file mode 100644
index 000000000000..9de453abf23d
--- /dev/null
+++ b/dev-packages/node-integration-tests/suites/anr/stop-and-start.js
@@ -0,0 +1,50 @@
+const crypto = require('crypto');
+const assert = require('assert');
+
+const Sentry = require('@sentry/node');
+
+setTimeout(() => {
+  process.exit();
+}, 10000);
+
+const anr = Sentry.anrIntegration({ captureStackTrace: true, anrThreshold: 100 });
+
+Sentry.init({
+  dsn: 'https://public@dsn.ingest.sentry.io/1337',
+  release: '1.0',
+  debug: true,
+  autoSessionTracking: false,
+  integrations: [anr],
+});
+
+function longWorkIgnored() {
+  for (let i = 0; i < 20; i++) {
+    const salt = crypto.randomBytes(128).toString('base64');
+    const hash = crypto.pbkdf2Sync('myPassword', salt, 10000, 512, 'sha512');
+    assert.ok(hash);
+  }
+}
+
+function longWork() {
+  for (let i = 0; i < 20; i++) {
+    const salt = crypto.randomBytes(128).toString('base64');
+    const hash = crypto.pbkdf2Sync('myPassword', salt, 10000, 512, 'sha512');
+    assert.ok(hash);
+  }
+}
+
+setTimeout(() => {
+  anr.stopWorker();
+
+  setTimeout(() => {
+    longWorkIgnored();
+
+    setTimeout(() => {
+      anr.startWorker();
+
+      setTimeout(() => {
+        longWork();
+      });
+    }, 2000);
+  }, 2000);
+}, 2000);
diff --git a/dev-packages/node-integration-tests/suites/anr/test.ts b/dev-packages/node-integration-tests/suites/anr/test.ts
index 966c47ad0370..9600978fb097 100644
--- a/dev-packages/node-integration-tests/suites/anr/test.ts
+++ b/dev-packages/node-integration-tests/suites/anr/test.ts
@@ -106,4 +106,8 @@ conditionalTest({ min: 16 })('should report ANR when event loop blocked', () =>
   test('from forked process', done => {
     createRunner(__dirname, 'forker.js').expect({ event: EXPECTED_ANR_EVENT }).start(done);
   });
+
+  test('worker can be stopped and restarted', done => {
+    createRunner(__dirname, 'stop-and-start.js').expect({ event: EXPECTED_ANR_EVENT }).start(done);
+  });
 });
diff --git a/packages/node/src/integrations/anr/index.ts b/packages/node/src/integrations/anr/index.ts
index 91deb2259e72..bf59b719fb18 100644
--- a/packages/node/src/integrations/anr/index.ts
+++ b/packages/node/src/integrations/anr/index.ts
@@ -1,7 +1,16 @@
 // TODO (v8): This import can be removed once we only support Node with global URL
 import { URL } from 'url';
 import { convertIntegrationFnToClass, defineIntegration, getCurrentScope } from '@sentry/core';
-import type { Client, Contexts, Event, EventHint, Integration, IntegrationClass, IntegrationFn } from '@sentry/types';
+import type {
+  Client,
+  Contexts,
+  Event,
+  EventHint,
+  Integration,
+  IntegrationClass,
+  IntegrationFn,
+  IntegrationFnResult,
+} from '@sentry/types';
 import { dynamicRequire, logger } from '@sentry/utils';
 import type { Worker, WorkerOptions } from 'worker_threads';
 import type { NodeClient } from '../../client';
@@ -52,23 +61,51 @@ interface InspectorApi {
 
 const INTEGRATION_NAME = 'Anr';
 
+type AnrInternal = { startWorker: () => void; stopWorker: () => void };
+
 const _anrIntegration = ((options: Partial<AnrIntegrationOptions> = {}) => {
+  let worker: Promise<() => void> | undefined;
+  let client: NodeClient | undefined;
+
   return {
     name: INTEGRATION_NAME,
     // TODO v8: Remove this
     setupOnce() {}, // eslint-disable-line @typescript-eslint/no-empty-function
-    setup(client: NodeClient) {
+    startWorker: () => {
+      if (worker) {
+        return;
+      }
+
+      if (client) {
+        worker = _startWorker(client, options);
+      }
+    },
+    stopWorker: () => {
+      if (worker) {
+        // eslint-disable-next-line @typescript-eslint/no-floating-promises
+        worker.then(stop => {
+          stop();
+          worker = undefined;
+        });
+      }
+    },
+    setup(initClient: NodeClient) {
       if (NODE_VERSION.major < 16 || (NODE_VERSION.major === 16 && NODE_VERSION.minor < 17)) {
         throw new Error('ANR detection requires Node 16.17.0 or later');
       }
 
-      // setImmediate is used to ensure that all other integrations have been setup
-      setImmediate(() => _startWorker(client, options));
+      client = initClient;
+
+      // setImmediate is used to ensure that all other integrations have had their setup called first.
+      // This allows us to call into all integrations to fetch the full context
+      setImmediate(() => this.startWorker());
     },
-  };
+  } as IntegrationFnResult & AnrInternal;
 }) satisfies IntegrationFn;
 
-export const anrIntegration = defineIntegration(_anrIntegration);
+type AnrReturn = (options?: Partial<AnrIntegrationOptions>) => IntegrationFnResult & AnrInternal;
+
+export const anrIntegration = defineIntegration(_anrIntegration) as AnrReturn;
 
 /**
  * Starts a thread to detect App Not Responding (ANR) events
@@ -90,14 +127,20 @@ export type Anr = typeof Anr;
 /**
  * Starts the ANR worker thread
  */
-async function _startWorker(client: NodeClient, _options: Partial<AnrIntegrationOptions>): Promise<void> {
-  const contexts = await getContexts(client);
+async function _startWorker(
+  client: NodeClient,
+  integrationOptions: Partial<AnrIntegrationOptions>,
+): Promise<() => void> {
   const dsn = client.getDsn();
 
   if (!dsn) {
-    return;
+    return () => {
+      //
+    };
   }
 
+  const contexts = await getContexts(client);
+
   // These will not be accurate if sent later from the worker thread
   delete contexts.app?.app_memory;
   delete contexts.device?.free_memory;
@@ -116,11 +159,11 @@ async function _startWorker(client: NodeClient, _options: Partial<AnrIntegration
     release: initOptions.release,
     dist: initOptions.dist,
     sdkMetadata,
-    appRootPath: _options.appRootPath,
-    pollInterval: _options.pollInterval || DEFAULT_INTERVAL,
-    anrThreshold: _options.anrThreshold || DEFAULT_HANG_THRESHOLD,
-    captureStackTrace: !!_options.captureStackTrace,
-    staticTags: _options.staticTags || {},
+    appRootPath: integrationOptions.appRootPath,
+    pollInterval: integrationOptions.pollInterval || DEFAULT_INTERVAL,
+    anrThreshold: integrationOptions.anrThreshold || DEFAULT_HANG_THRESHOLD,
+    captureStackTrace: !!integrationOptions.captureStackTrace,
+    staticTags: integrationOptions.staticTags || {},
     contexts,
   };
 
@@ -139,6 +182,7 @@ async function _startWorker(client: NodeClient, _options: Partial<AnrIntegration
   });
 
   process.on('exit', () => {
+    // eslint-disable-next-line @typescript-eslint/no-floating-promises
     worker.terminate();
   });
 
@@ -176,4 +220,10 @@ async function _startWorker(client: NodeClient, _options: Partial<AnrIntegration
 
   // Ensure this thread can't block app exit
   worker.unref();
+
+  return () => {
+    // eslint-disable-next-line @typescript-eslint/no-floating-promises
+    worker.terminate();
+    clearInterval(timer);
+  };
 }