diff --git a/dev-packages/node-integration-tests/package.json b/dev-packages/node-integration-tests/package.json
index f36333c4daa8..c166d539c925 100644
--- a/dev-packages/node-integration-tests/package.json
+++ b/dev-packages/node-integration-tests/package.json
@@ -40,6 +40,7 @@
     "graphql": "^16.3.0",
     "http-terminator": "^3.2.0",
     "mongodb": "^3.7.3",
+    "mongoose": "^5.13.22",
     "mongodb-memory-server-global": "^7.6.3",
     "mysql": "^2.18.1",
     "nock": "^13.1.0",
diff --git a/dev-packages/node-integration-tests/suites/tracing-experimental/mongoose/scenario.js b/dev-packages/node-integration-tests/suites/tracing-experimental/mongoose/scenario.js
new file mode 100644
index 000000000000..47a67e4aaf78
--- /dev/null
+++ b/dev-packages/node-integration-tests/suites/tracing-experimental/mongoose/scenario.js
@@ -0,0 +1,50 @@
+const { loggingTransport } = require('@sentry-internal/node-integration-tests');
+const Sentry = require('@sentry/node-experimental');
+
+Sentry.init({
+  dsn: 'https://public@dsn.ingest.sentry.io/1337',
+  release: '1.0',
+  debug: true,
+  tracesSampleRate: 1.0,
+  transport: loggingTransport,
+});
+
+// Stop the process from exiting before the transaction is sent
+setInterval(() => {}, 1000);
+
+// Must be required after Sentry is initialized
+const mongoose = require('mongoose');
+
+async function run() {
+  await mongoose.connect(process.env.MONGO_URL || '');
+
+  const Schema = mongoose.Schema;
+
+  const BlogPostSchema = new Schema({
+    title: String,
+    body: String,
+    date: Date,
+  });
+
+  const BlogPost = mongoose.model('BlogPost', BlogPostSchema);
+
+  await Sentry.startSpan(
+    {
+      name: 'Test Transaction',
+      op: 'transaction',
+    },
+    async () => {
+      const post = new BlogPost();
+      post.title = 'Test';
+      post.body = 'Test body';
+      post.date = new Date();
+
+      await post.save();
+
+      await BlogPost.findOne({});
+    },
+  );
+}
+
+// eslint-disable-next-line @typescript-eslint/no-floating-promises
+run();
diff --git a/dev-packages/node-integration-tests/suites/tracing-experimental/mongoose/test.ts b/dev-packages/node-integration-tests/suites/tracing-experimental/mongoose/test.ts
new file mode 100644
index 000000000000..1a246d8ec5b9
--- /dev/null
+++ b/dev-packages/node-integration-tests/suites/tracing-experimental/mongoose/test.ts
@@ -0,0 +1,54 @@
+import { MongoMemoryServer } from 'mongodb-memory-server-global';
+
+import { conditionalTest } from '../../../utils';
+import { cleanupChildProcesses, createRunner } from '../../../utils/runner';
+
+jest.setTimeout(20000);
+
+conditionalTest({ min: 14 })('Mongoose experimental Test', () => {
+  let mongoServer: MongoMemoryServer;
+
+  beforeAll(async () => {
+    mongoServer = await MongoMemoryServer.create();
+    process.env.MONGO_URL = mongoServer.getUri();
+  }, 10000);
+
+  afterAll(async () => {
+    if (mongoServer) {
+      await mongoServer.stop();
+    }
+    cleanupChildProcesses();
+  });
+
+  const EXPECTED_TRANSACTION = {
+    transaction: 'Test Transaction',
+    spans: expect.arrayContaining([
+      expect.objectContaining({
+        data: expect.objectContaining({
+          'db.mongodb.collection': 'blogposts',
+          'db.name': 'test',
+          'db.operation': 'save',
+          'db.system': 'mongoose',
+        }),
+        description: 'mongoose.BlogPost.save',
+        op: 'db',
+        origin: 'auto.db.otel.mongoose',
+      }),
+      expect.objectContaining({
+        data: expect.objectContaining({
+          'db.mongodb.collection': 'blogposts',
+          'db.name': 'test',
+          'db.operation': 'findOne',
+          'db.system': 'mongoose',
+        }),
+        description: 'mongoose.BlogPost.findOne',
+        op: 'db',
+        origin: 'auto.db.otel.mongoose',
+      }),
+    ]),
+  };
+
+  test('CJS - should auto-instrument `mongoose` package.', done => {
+    createRunner(__dirname, 'scenario.js').expect({ transaction: EXPECTED_TRANSACTION }).start(done);
+  });
+});
diff --git a/yarn.lock b/yarn.lock
index 2a082acd3aa5..30ebd84ec912 100644
--- a/yarn.lock
+++ b/yarn.lock
@@ -5739,6 +5739,13 @@
   dependencies:
     bson "*"
 
+"@types/bson@1.x || 4.0.x":
+  version "4.0.5"
+  resolved "https://registry.yarnpkg.com/@types/bson/-/bson-4.0.5.tgz#9e0e1d1a6f8866483f96868a9b33bc804926b1fc"
+  integrity sha512-vVLwMUqhYJSQ/WKcE60eFqcyuWse5fGH+NMAXHuKrUAPoryq3ATxk5o4bgYNtg5aOM4APVg7Hnb3ASqUYG0PKg==
+  dependencies:
+    "@types/node" "*"
+
 "@types/chai-as-promised@^7.1.2":
   version "7.1.3"
   resolved "https://registry.yarnpkg.com/@types/chai-as-promised/-/chai-as-promised-7.1.3.tgz#779166b90fda611963a3adbfd00b339d03b747bd"
@@ -6309,7 +6316,7 @@
   resolved "https://registry.yarnpkg.com/@types/minimist/-/minimist-1.2.1.tgz#283f669ff76d7b8260df8ab7a4262cc83d988256"
   integrity sha512-fZQQafSREFyuZcdWFAExYjBiCL7AUCdgsk80iO0q4yihYYdcIiH28CcuPTGFgLOCC8RlW49GSQxdHwZP+I7CNg==
 
-"@types/mongodb@^3.6.20":
+"@types/mongodb@^3.5.27", "@types/mongodb@^3.6.20":
   version "3.6.20"
   resolved "https://registry.yarnpkg.com/@types/mongodb/-/mongodb-3.6.20.tgz#b7c5c580644f6364002b649af1c06c3c0454e1d2"
   integrity sha512-WcdpPJCakFzcWWD9juKoZbRtQxKIMYF/JIAM4JrNHrMcnJL6/a2NWjXxW7fo9hxboxxkg+icff8d7+WIEvKgYQ==
@@ -9535,6 +9542,11 @@ blank-object@^1.0.1:
   resolved "https://registry.yarnpkg.com/blank-object/-/blank-object-1.0.2.tgz#f990793fbe9a8c8dd013fb3219420bec81d5f4b9"
   integrity sha1-+ZB5P76ajI3QE/syGUIL7IHV9Lk=
 
+bluebird@3.5.1:
+  version "3.5.1"
+  resolved "https://registry.yarnpkg.com/bluebird/-/bluebird-3.5.1.tgz#d9551f9de98f1fcda1e683d17ee91a0602ee2eb9"
+  integrity sha512-MKiLiV+I1AA596t9w1sQJ8jkiSr5+ZKi0WKrYGUn6d1Fx+Ij4tIj+m2WMQSGczs5jZVxV339chE8iwk6F64wjA==
+
 bluebird@^3.4.6, bluebird@^3.5.1, bluebird@^3.5.3, bluebird@^3.5.5, bluebird@^3.7.2:
   version "3.7.2"
   resolved "https://registry.yarnpkg.com/bluebird/-/bluebird-3.7.2.tgz#9f229c15be272454ffa973ace0dbee79a1b0c36f"
@@ -19616,6 +19628,11 @@ jws@^4.0.0:
     jwa "^2.0.0"
     safe-buffer "^5.0.1"
 
+kareem@2.3.2:
+  version "2.3.2"
+  resolved "https://registry.yarnpkg.com/kareem/-/kareem-2.3.2.tgz#78c4508894985b8d38a0dc15e1a8e11078f2ca93"
+  integrity sha512-STHz9P7X2L4Kwn72fA4rGyqyXdmrMSdxqHx9IXon/FXluXieaFA6KJ2upcHAHxQPQ0LeM/OjLrhFxifHewOALQ==
+
 karma-browserstack-launcher@^1.5.1:
   version "1.6.0"
   resolved "https://registry.yarnpkg.com/karma-browserstack-launcher/-/karma-browserstack-launcher-1.6.0.tgz#2f6000647073e77ae296653b8830b279669766ef"
@@ -22120,6 +22137,19 @@ mongodb-memory-server-global@^7.6.3:
     mongodb-memory-server-core "7.6.3"
     tslib "^2.3.0"
 
+mongodb@3.7.4:
+  version "3.7.4"
+  resolved "https://registry.yarnpkg.com/mongodb/-/mongodb-3.7.4.tgz#119530d826361c3e12ac409b769796d6977037a4"
+  integrity sha512-K5q8aBqEXMwWdVNh94UQTwZ6BejVbFhh1uB6c5FKtPE9eUMZPUO3sRZdgIEcHSrAWmxzpG/FeODDKL388sqRmw==
+  dependencies:
+    bl "^2.2.1"
+    bson "^1.1.4"
+    denque "^1.4.1"
+    optional-require "^1.1.8"
+    safe-buffer "^5.1.2"
+  optionalDependencies:
+    saslprep "^1.0.0"
+
 mongodb@^3.7.3:
   version "3.7.3"
   resolved "https://registry.yarnpkg.com/mongodb/-/mongodb-3.7.3.tgz#b7949cfd0adc4cc7d32d3f2034214d4475f175a5"
@@ -22133,6 +22163,31 @@ mongodb@^3.7.3:
   optionalDependencies:
     saslprep "^1.0.0"
 
+mongoose-legacy-pluralize@1.0.2:
+  version "1.0.2"
+  resolved "https://registry.yarnpkg.com/mongoose-legacy-pluralize/-/mongoose-legacy-pluralize-1.0.2.tgz#3ba9f91fa507b5186d399fb40854bff18fb563e4"
+  integrity sha512-Yo/7qQU4/EyIS8YDFSeenIvXxZN+ld7YdV9LqFVQJzTLye8unujAWPZ4NWKfFA+RNjh+wvTWKY9Z3E5XM6ZZiQ==
+
+mongoose@^5.13.22:
+  version "5.13.22"
+  resolved "https://registry.yarnpkg.com/mongoose/-/mongoose-5.13.22.tgz#f9a6493ba5f45b7a3d5f9fce58ca9c71aedb8157"
+  integrity sha512-p51k/c4X/MfqeQ3I1ranlDiggLzNumZrTDD9CeezHwZxt2/btf+YZD7MCe07RAY2NgFYVMayq6jMamw02Jmf9w==
+  dependencies:
+    "@types/bson" "1.x || 4.0.x"
+    "@types/mongodb" "^3.5.27"
+    bson "^1.1.4"
+    kareem "2.3.2"
+    mongodb "3.7.4"
+    mongoose-legacy-pluralize "1.0.2"
+    mpath "0.8.4"
+    mquery "3.2.5"
+    ms "2.1.2"
+    optional-require "1.0.x"
+    regexp-clone "1.0.0"
+    safe-buffer "5.2.1"
+    sift "13.5.2"
+    sliced "1.0.1"
+
 morgan@^1.10.0:
   version "1.10.0"
   resolved "https://registry.yarnpkg.com/morgan/-/morgan-1.10.0.tgz#091778abc1fc47cd3509824653dae1faab6b17d7"
@@ -22161,6 +22216,22 @@ move-concurrently@^1.0.1:
     rimraf "^2.5.4"
     run-queue "^1.0.3"
 
+mpath@0.8.4:
+  version "0.8.4"
+  resolved "https://registry.yarnpkg.com/mpath/-/mpath-0.8.4.tgz#6b566d9581621d9e931dd3b142ed3618e7599313"
+  integrity sha512-DTxNZomBcTWlrMW76jy1wvV37X/cNNxPW1y2Jzd4DZkAaC5ZGsm8bfGfNOthcDuRJujXLqiuS6o3Tpy0JEoh7g==
+
+mquery@3.2.5:
+  version "3.2.5"
+  resolved "https://registry.yarnpkg.com/mquery/-/mquery-3.2.5.tgz#8f2305632e4bb197f68f60c0cffa21aaf4060c51"
+  integrity sha512-VjOKHHgU84wij7IUoZzFRU07IAxd5kWJaDmyUzQlbjHjyoeK5TNeeo8ZsFDtTYnSgpW6n/nMNIHvE3u8Lbrf4A==
+  dependencies:
+    bluebird "3.5.1"
+    debug "3.1.0"
+    regexp-clone "^1.0.0"
+    safe-buffer "5.1.2"
+    sliced "1.0.1"
+
 mri@1.1.4:
   version "1.1.4"
   resolved "https://registry.yarnpkg.com/mri/-/mri-1.1.4.tgz#7cb1dd1b9b40905f1fac053abe25b6720f44744a"
@@ -23488,6 +23559,11 @@ opn@^5.5.0:
   dependencies:
     is-wsl "^1.1.0"
 
+optional-require@1.0.x:
+  version "1.0.3"
+  resolved "https://registry.yarnpkg.com/optional-require/-/optional-require-1.0.3.tgz#275b8e9df1dc6a17ad155369c2422a440f89cb07"
+  integrity sha512-RV2Zp2MY2aeYK5G+B/Sps8lW5NHAzE5QClbFP15j+PWmP+T9PxlJXBOOLoSAdgwFvS4t0aMR4vpedMkbHfh0nA==
+
 optional-require@^1.1.8:
   version "1.1.8"
   resolved "https://registry.yarnpkg.com/optional-require/-/optional-require-1.1.8.tgz#16364d76261b75d964c482b2406cb824d8ec44b7"
@@ -26650,6 +26726,11 @@ regex-parser@^2.2.11:
   resolved "https://registry.yarnpkg.com/regex-parser/-/regex-parser-2.2.11.tgz#3b37ec9049e19479806e878cabe7c1ca83ccfe58"
   integrity sha512-jbD/FT0+9MBU2XAZluI7w2OBs1RBi6p9M83nkoZayQXXU9e8Robt69FcZc7wU4eJD/YFTjn1JdCk3rbMJajz8Q==
 
+regexp-clone@1.0.0, regexp-clone@^1.0.0:
+  version "1.0.0"
+  resolved "https://registry.yarnpkg.com/regexp-clone/-/regexp-clone-1.0.0.tgz#222db967623277056260b992626354a04ce9bf63"
+  integrity sha512-TuAasHQNamyyJ2hb97IuBEif4qBHGjPHBS64sZwytpLEqtBQ1gPJTnOaQ6qmpET16cK14kkjbazl6+p0RRv0yw==
+
 regexp.prototype.flags@^1.2.0, regexp.prototype.flags@^1.4.3:
   version "1.4.3"
   resolved "https://registry.yarnpkg.com/regexp.prototype.flags/-/regexp.prototype.flags-1.4.3.tgz#87cab30f80f66660181a3bb7bf5981a872b367ac"
@@ -28042,6 +28123,11 @@ side-channel@^1.0.4:
     get-intrinsic "^1.0.2"
     object-inspect "^1.9.0"
 
+sift@13.5.2:
+  version "13.5.2"
+  resolved "https://registry.yarnpkg.com/sift/-/sift-13.5.2.tgz#24a715e13c617b086166cd04917d204a591c9da6"
+  integrity sha512-+gxdEOMA2J+AI+fVsCqeNn7Tgx3M9ZN9jdi95939l1IJ8cZsqS8sqpJyOkic2SJk+1+98Uwryt/gL6XDaV+UZA==
+
 siginfo@^2.0.0:
   version "2.0.0"
   resolved "https://registry.yarnpkg.com/siginfo/-/siginfo-2.0.0.tgz#32e76c70b79724e3bb567cb9d543eb858ccfaf30"
@@ -28212,6 +28298,11 @@ slice-ansi@^5.0.0:
     ansi-styles "^6.0.0"
     is-fullwidth-code-point "^4.0.0"
 
+sliced@1.0.1:
+  version "1.0.1"
+  resolved "https://registry.yarnpkg.com/sliced/-/sliced-1.0.1.tgz#0b3a662b5d04c3177b1926bea82b03f837a2ef41"
+  integrity sha512-VZBmZP8WU3sMOZm1bdgTadsQbcscK0UM8oKxKVBs4XAhUo2Xxzm/OFMGBkPusxw9xL3Uy8LrzEqGqJhclsr0yA==
+
 smart-buffer@^4.1.0, smart-buffer@^4.2.0:
   version "4.2.0"
   resolved "https://registry.yarnpkg.com/smart-buffer/-/smart-buffer-4.2.0.tgz#6e1d71fa4f18c05f7d0ff216dd16a481d0e8d9ae"