diff --git a/setup.py b/setup.py
index e8842146fb..fa93fc5d8f 100644
--- a/setup.py
+++ b/setup.py
@@ -138,15 +138,22 @@ class BuildFailed(Exception):
     def __init__(self, ext):
         self.ext = ext
 
+is_windows = sys.platform.startswith('win32')
+is_macos = sys.platform.startswith('darwin')
 
 murmur3_ext = Extension('cassandra.cmurmur3',
                         sources=['cassandra/cmurmur3.c'])
 
+libev_includes = ['/usr/include/libev', '/usr/local/include', '/opt/local/include', '/usr/include']
+libev_libdirs = ['/usr/local/lib', '/opt/local/lib', '/usr/lib64']
+if is_macos:
+    libev_includes.extend(['/opt/homebrew/include', os.path.expanduser('~/homebrew/include')])
+    libev_libdirs.extend(['/opt/homebrew/lib'])
 libev_ext = Extension('cassandra.io.libevwrapper',
                       sources=['cassandra/io/libevwrapper.c'],
-                      include_dirs=['/usr/include/libev', '/usr/local/include', '/opt/local/include', '/opt/homebrew/include', os.path.expanduser('~/homebrew/include')],
+                      include_dirs=libev_includes,
                       libraries=['ev'],
-                      library_dirs=['/usr/local/lib', '/opt/local/lib'])
+                      library_dirs=libev_libdirs)
 
 platform_unsupported_msg = \
 """
@@ -169,8 +176,6 @@ def __init__(self, ext):
 =================================================================================
 """
 
-is_windows = os.name == 'nt'
-
 is_pypy = "PyPy" in sys.version
 if is_pypy:
     sys.stderr.write(pypy_unsupported_msg)