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262 | 262 | proposal: /assets/docs/Aditya_Pandey_GSoC2025.pdf
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263 | 263 | mentors: Martin Vassilev, Jonas Rembser, Fons Rademakers, Vassil Vassilev
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264 | 264 |
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| 265 | +- name: Salvador de la Torre Gonzalez |
| 266 | + info: "Google Summer of Code 2025 Contributor" |
| 267 | + photo: salva_de_la_torre_gonzalez.jpg |
| 268 | + |
| 269 | + github: "https://github.com/salva24" |
| 270 | + linkedin: "https://www.linkedin.com/in/salva-de-la-torre-gonzalez-7299b6335/" |
| 271 | + education: "Mathematics and Computer Engineering, University of Seville, Spain" |
| 272 | + active: 1 |
| 273 | + projects: |
| 274 | + - title: "Agent-Based Simulation of CAR-T Cell Therapy Using BioDynaMo" |
| 275 | + status: Ongoing |
| 276 | + description: | |
| 277 | + Chimeric Antigen Receptor T-cell (CAR-T) therapy has shown great promise |
| 278 | + in treating hematological cancers by harnessing the immune system to target |
| 279 | + and eliminate tumor cells. However, its effectiveness in solid tumors remains |
| 280 | + limited due to challenges such as poor T-cell infiltration, immune suppression, |
| 281 | + and T-cell exhaustion. This project aims to develop a scalable, agent-based |
| 282 | + simulation of CAR-T therapy using BioDynaMo, a high-performance, open-source |
| 283 | + biological simulation platform. The simulation will model key aspects of CAR-T |
| 284 | + dynamics, including T-cell migration, tumor cell engagement, and the influence |
| 285 | + of microenvironmental factors like hypoxia, regulatory T-cells, and |
| 286 | + immunosuppressive cytokines. By simulating various tumor types, including solid |
| 287 | + tumors and leukemias, the model will explore treatment variables such as CAR-T |
| 288 | + dosage, timing of administration, and combination strategies like checkpoint |
| 289 | + inhibitors and cytokine support. The project will deliver a complete and |
| 290 | + well-documented BioDynaMo-based simulation modeling CAR-T cell therapy, |
| 291 | + custom analysis scripts for visualizing tumor regression and evaluating CAR-T |
| 292 | + efficacy, performance benchmarking across therapeutic strategies, and a detailed |
| 293 | + report summarizing insights and future directions. This approach will provide |
| 294 | + valuable insights for optimizing CAR-T therapies, particularly in complex tumor |
| 295 | + microenvironments. |
| 296 | + proposal: /assets/docs/de_la_torre_gonzalez_salvador_proposal_gsoc_2025.pdf |
| 297 | + mentors: Vassil Vassilev, Lukas Breitwieser |
| 298 | + |
265 | 299 | - name: "This could be you!"
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266 | 300 | photo: rock.jpg
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267 | 301 | info: See <a href="/careers">openings</a> for more info
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