diff --git a/cloudpickle/cloudpickle.py b/cloudpickle/cloudpickle.py
index b1107ba92..f3c0590de 100644
--- a/cloudpickle/cloudpickle.py
+++ b/cloudpickle/cloudpickle.py
@@ -635,11 +635,12 @@ def extract_func_data(self, func):
 
         base_globals = self.globals_ref.get(id(func.__globals__), None)
         if base_globals is None:
-            # For functions defined in __main__, use vars(__main__) for
-            # base_global. This is necessary to share the global variables
-            # across multiple functions in this module.
-            if func.__module__ == "__main__":
-                base_globals = "__main__"
+            # For functions defined in a well behaved module use
+            # vars(func.__module__) for base_globals. This is necessary to
+            # share the global variables across multiple pickled functions from
+            # this module.
+            if hasattr(func, '__module__') and func.__module__ is not None:
+                base_globals = func.__module__
             else:
                 base_globals = {}
         self.globals_ref[id(func.__globals__)] = base_globals
diff --git a/tests/cloudpickle_test.py b/tests/cloudpickle_test.py
index f1c3ea55b..534993e2c 100644
--- a/tests/cloudpickle_test.py
+++ b/tests/cloudpickle_test.py
@@ -47,6 +47,9 @@
 from .testutils import assert_run_python_script
 
 
+_TEST_GLOBAL_VARIABLE = "default_value"
+
+
 class RaiserOnPickle(object):
 
     def __init__(self, exc):
@@ -887,6 +890,39 @@ def f1():
                                         clone_func=clone_func)
             assert_run_python_script(textwrap.dedent(code))
 
+    def test_closure_interacting_with_a_global_variable(self):
+        global _TEST_GLOBAL_VARIABLE
+        orig_value = _TEST_GLOBAL_VARIABLE
+        try:
+            def f0():
+                global _TEST_GLOBAL_VARIABLE
+                _TEST_GLOBAL_VARIABLE = "changed_by_f0"
+
+            def f1():
+                return _TEST_GLOBAL_VARIABLE
+
+            cloned_f0 = cloudpickle.loads(cloudpickle.dumps(
+                f0, protocol=self.protocol))
+            cloned_f1 = cloudpickle.loads(cloudpickle.dumps(
+                f1, protocol=self.protocol))
+            pickled_f1 = cloudpickle.dumps(f1, protocol=self.protocol)
+
+            # Change the value of the global variable
+            cloned_f0()
+
+            # Ensure that the global variable is the same for another function
+            result_f1 = cloned_f1()
+            assert result_f1 == "changed_by_f0", result_f1
+            assert f1() == result_f1
+
+            # Ensure that unpickling the global variable does not change its
+            # value
+            result_pickled_f1 = cloudpickle.loads(pickled_f1)()
+            assert result_pickled_f1 == "changed_by_f0", result_pickled_f1
+        finally:
+            _TEST_GLOBAL_VARIABLE = orig_value
+
+
     @pytest.mark.skipif(sys.version_info >= (3, 0),
                         reason="hardcoded pickle bytes for 2.7")
     def test_function_pickle_compat_0_4_0(self):