diff --git a/.github/workflows/ci_tests.yaml b/.github/workflows/ci_tests.yaml
index 86e3e8df..b1ccda1f 100644
--- a/.github/workflows/ci_tests.yaml
+++ b/.github/workflows/ci_tests.yaml
@@ -25,7 +25,6 @@ jobs:
           - os: macos-latest
             architecture: x64
         python:
-          - 3.5
           - 3.6
           - 3.7
           - 3.8
diff --git a/README.rst b/README.rst
index 6881c2e1..b472e75e 100644
--- a/README.rst
+++ b/README.rst
@@ -47,7 +47,7 @@ Getting Started
 Required Prerequisites
 ======================
 
-* Python 3.5+
+* Python 3.6+
 
 
 Installation
diff --git a/buildspec.yml b/buildspec.yml
index b2a19641..d6b651bd 100644
--- a/buildspec.yml
+++ b/buildspec.yml
@@ -3,8 +3,6 @@ version: 0.2
 batch:
   fast-fail: false
   build-list:
-    - identifier: python3_5
-      buildspec: codebuild/python3.5.yml
     - identifier: python3_6
       buildspec: codebuild/python3.6.yml
     - identifier: python3_7
diff --git a/codebuild/python3.5.yml b/codebuild/python3.5.yml
index f0916074..e69de29b 100644
--- a/codebuild/python3.5.yml
+++ b/codebuild/python3.5.yml
@@ -1,32 +0,0 @@
-version: 0.2
-
-env:
-  variables:
-    TOXENV: "py35-integ-slow"
-    AWS_ENCRYPTION_SDK_PYTHON_INTEGRATION_TEST_AWS_KMS_KEY_ID: >-
-      arn:aws:kms:us-west-2:658956600833:key/b3537ef1-d8dc-4780-9f5a-55776cbb2f7f
-    AWS_ENCRYPTION_SDK_PYTHON_INTEGRATION_TEST_AWS_KMS_KEY_ID_2: >-
-      arn:aws:kms:eu-central-1:658956600833:key/75414c93-5285-4b57-99c9-30c1cf0a22c2
-
-phases:
-  install:
-    runtime-versions:
-        python: latest
-  build:
-    commands:
-      # The specific versions are manually installed
-      # because they are not installed
-      # by default in CodeBuild containers.
-      # `pyenv` does not have
-      # a nice way to just install
-      # the latest patch version.
-      # I have selected the current latest patch
-      # rather than try
-      # and manage a one-liner or script.
-      # Testing every minor version
-      # is too extreme at this time.
-      # The choice of versions should be reviewed.
-      - pyenv install 3.5.10
-      - pyenv local 3.5.10
-      - pip install tox tox-pyenv
-      - tox
diff --git a/examples/tox.ini b/examples/tox.ini
index 67fa6318..ef7d4072 100644
--- a/examples/tox.ini
+++ b/examples/tox.ini
@@ -2,7 +2,7 @@
 
 [tox]
 envlist =
-    py{27,35,36,37,38,39}-examples
+    py{36,37,38,39}-examples
 
 [testenv:base-command]
 commands = python -m pytest --basetemp={envtmpdir} -l {posargs}
diff --git a/setup.py b/setup.py
index 5ae2a7ef..c696bfd2 100644
--- a/setup.py
+++ b/setup.py
@@ -48,7 +48,6 @@ def get_requirements():
         "License :: OSI Approved :: Apache Software License",
         "Programming Language :: Python",
         "Programming Language :: Python :: 3",
-        "Programming Language :: Python :: 3.5",
         "Programming Language :: Python :: 3.6",
         "Programming Language :: Python :: 3.7",
         "Programming Language :: Python :: 3.8",
diff --git a/tox.ini b/tox.ini
index 3c4a9e4e..1a9d21cc 100644
--- a/tox.ini
+++ b/tox.ini
@@ -1,6 +1,6 @@
 [tox]
 envlist =
-    py{35,36,37,38,39,310}-{local,integ,ddb,examples}-fast,
+    py{36,37,38,39,310}-{local,integ,ddb,examples}-fast,
     nocmk, sourcebuildcheck,
     docs, bandit, doc8, readme,
     flake8{,-tests,-examples}, pylint{,-tests,-examples},