diff --git a/aws_lambda_powertools/event_handler/api_gateway.py b/aws_lambda_powertools/event_handler/api_gateway.py
index 962fd51ccf4..75301a8928c 100644
--- a/aws_lambda_powertools/event_handler/api_gateway.py
+++ b/aws_lambda_powertools/event_handler/api_gateway.py
@@ -177,6 +177,7 @@ def __init__(
         body: Union[str, bytes, None] = None,
         headers: Optional[Dict[str, Union[str, List[str]]]] = None,
         cookies: Optional[List[Cookie]] = None,
+        compress: Optional[bool] = None,
     ):
         """
 
@@ -199,6 +200,7 @@ def __init__(
         self.base64_encoded = False
         self.headers: Dict[str, Union[str, List[str]]] = headers if headers else {}
         self.cookies = cookies or []
+        self.compress = compress
         if content_type:
             self.headers.setdefault("Content-Type", content_type)
 
@@ -233,6 +235,38 @@ def _add_cache_control(self, cache_control: str):
         cache_control = cache_control if self.response.status_code == 200 else "no-cache"
         self.response.headers["Cache-Control"] = cache_control
 
+    @staticmethod
+    def _has_compression_enabled(
+        route_compression: bool, response_compression: Optional[bool], event: BaseProxyEvent
+    ) -> bool:
+        """
+        Checks if compression is enabled.
+
+        NOTE: Response compression takes precedence.
+
+        Parameters
+        ----------
+        route_compression: bool, optional
+            A boolean indicating whether compression is enabled or not in the route setting.
+        response_compression: bool, optional
+            A boolean indicating whether compression is enabled or not in the response setting.
+        event: BaseProxyEvent
+            The event object containing the request details.
+
+        Returns
+        -------
+        bool
+            True if compression is enabled and the "gzip" encoding is accepted, False otherwise.
+        """
+        encoding: str = event.get_header_value(name="accept-encoding", default_value="", case_sensitive=False)  # type: ignore[assignment] # noqa: E501
+        if "gzip" in encoding:
+            if response_compression is not None:
+                return response_compression  # e.g., Response(compress=False/True))
+            if route_compression:
+                return True  # e.g., @app.get(compress=True)
+
+        return False
+
     def _compress(self):
         """Compress the response body, but only if `Accept-Encoding` headers includes gzip."""
         self.response.headers["Content-Encoding"] = "gzip"
@@ -250,7 +284,9 @@ def _route(self, event: BaseProxyEvent, cors: Optional[CORSConfig]):
             self._add_cors(event, cors or CORSConfig())
         if self.route.cache_control:
             self._add_cache_control(self.route.cache_control)
-        if self.route.compress and "gzip" in (event.get_header_value("accept-encoding", "") or ""):
+        if self._has_compression_enabled(
+            route_compression=self.route.compress, response_compression=self.response.compress, event=event
+        ):
             self._compress()
 
     def build(self, event: BaseProxyEvent, cors: Optional[CORSConfig] = None) -> Dict[str, Any]:
diff --git a/aws_lambda_powertools/utilities/data_classes/common.py b/aws_lambda_powertools/utilities/data_classes/common.py
index a862c7da454..c778040906d 100644
--- a/aws_lambda_powertools/utilities/data_classes/common.py
+++ b/aws_lambda_powertools/utilities/data_classes/common.py
@@ -154,6 +154,7 @@ def get_query_string_value(self, name: str, default_value: Optional[str] = None)
             query_string_parameters=self.query_string_parameters, name=name, default_value=default_value
         )
 
+    # Maintenance: missing @overload to ensure return type is a str when default_value is set
     def get_header_value(
         self, name: str, default_value: Optional[str] = None, case_sensitive: Optional[bool] = False
     ) -> Optional[str]:
diff --git a/docs/core/event_handler/api_gateway.md b/docs/core/event_handler/api_gateway.md
index 0fafba80b47..ef544a57d0f 100644
--- a/docs/core/event_handler/api_gateway.md
+++ b/docs/core/event_handler/api_gateway.md
@@ -360,15 +360,24 @@ You can use the `Response` class to have full control over the response. For exa
 
 ### Compress
 
-You can compress with gzip and base64 encode your responses via `compress` parameter.
+You can compress with gzip and base64 encode your responses via `compress` parameter. You have the option to pass the `compress` parameter when working with a specific route or using the Response object.
+
+???+ info
+    The `compress` parameter used in the Response object takes precedence over the one used in the route.
 
 ???+ warning
     The client must send the `Accept-Encoding` header, otherwise a normal response will be sent.
 
-=== "compressing_responses.py"
+=== "compressing_responses_using_route.py"
 
     ```python hl_lines="17 27"
-     --8<-- "examples/event_handler_rest/src/compressing_responses.py"
+     --8<-- "examples/event_handler_rest/src/compressing_responses_using_route.py"
+    ```
+
+=== "compressing_responses_using_response.py"
+
+    ```python hl_lines="24"
+     --8<-- "examples/event_handler_rest/src/compressing_responses_using_response.py"
     ```
 
 === "compressing_responses.json"
diff --git a/examples/event_handler_rest/src/compressing_responses_using_response.py b/examples/event_handler_rest/src/compressing_responses_using_response.py
new file mode 100644
index 00000000000..b777ab40af9
--- /dev/null
+++ b/examples/event_handler_rest/src/compressing_responses_using_response.py
@@ -0,0 +1,31 @@
+import requests
+
+from aws_lambda_powertools import Logger, Tracer
+from aws_lambda_powertools.event_handler import (
+    APIGatewayRestResolver,
+    Response,
+    content_types,
+)
+from aws_lambda_powertools.logging import correlation_paths
+from aws_lambda_powertools.utilities.typing import LambdaContext
+
+tracer = Tracer()
+logger = Logger()
+app = APIGatewayRestResolver()
+
+
+@app.get("/todos")
+@tracer.capture_method
+def get_todos():
+    todos: requests.Response = requests.get("https://jsonplaceholder.typicode.com/todos")
+    todos.raise_for_status()
+
+    # for brevity, we'll limit to the first 10 only
+    return Response(status_code=200, content_type=content_types.APPLICATION_JSON, body=todos.json()[:10], compress=True)
+
+
+# You can continue to use other utilities just as before
+@logger.inject_lambda_context(correlation_id_path=correlation_paths.API_GATEWAY_REST)
+@tracer.capture_lambda_handler
+def lambda_handler(event: dict, context: LambdaContext) -> dict:
+    return app.resolve(event, context)
diff --git a/examples/event_handler_rest/src/compressing_responses.py b/examples/event_handler_rest/src/compressing_responses_using_route.py
similarity index 100%
rename from examples/event_handler_rest/src/compressing_responses.py
rename to examples/event_handler_rest/src/compressing_responses_using_route.py
diff --git a/tests/functional/event_handler/test_api_gateway.py b/tests/functional/event_handler/test_api_gateway.py
index c17422f8d94..9d2d3c5184e 100644
--- a/tests/functional/event_handler/test_api_gateway.py
+++ b/tests/functional/event_handler/test_api_gateway.py
@@ -366,6 +366,58 @@ def test_cors_preflight_body_is_empty_not_null():
     assert result["body"] == ""
 
 
+def test_override_route_compress_parameter():
+    # GIVEN a function that has compress=True
+    # AND an event with a "Accept-Encoding" that include gzip
+    # AND the Response object with compress=False
+    app = ApiGatewayResolver()
+    mock_event = {"path": "/my/request", "httpMethod": "GET", "headers": {"Accept-Encoding": "deflate, gzip"}}
+    expected_value = '{"test": "value"}'
+
+    @app.get("/my/request", compress=True)
+    def with_compression() -> Response:
+        return Response(200, content_types.APPLICATION_JSON, expected_value, compress=False)
+
+    def handler(event, context):
+        return app.resolve(event, context)
+
+    # WHEN calling the event handler
+    result = handler(mock_event, None)
+
+    # THEN then the response is not compressed
+    assert result["isBase64Encoded"] is False
+    assert result["body"] == expected_value
+    assert result["multiValueHeaders"].get("Content-Encoding") is None
+
+
+def test_response_with_compress_enabled():
+    # GIVEN a function
+    # AND an event with a "Accept-Encoding" that include gzip
+    # AND the Response object with compress=True
+    app = ApiGatewayResolver()
+    mock_event = {"path": "/my/request", "httpMethod": "GET", "headers": {"Accept-Encoding": "deflate, gzip"}}
+    expected_value = '{"test": "value"}'
+
+    @app.get("/my/request")
+    def route_without_compression() -> Response:
+        return Response(200, content_types.APPLICATION_JSON, expected_value, compress=True)
+
+    def handler(event, context):
+        return app.resolve(event, context)
+
+    # WHEN calling the event handler
+    result = handler(mock_event, None)
+
+    # THEN then gzip the response and base64 encode as a string
+    assert result["isBase64Encoded"] is True
+    body = result["body"]
+    assert isinstance(body, str)
+    decompress = zlib.decompress(base64.b64decode(body), wbits=zlib.MAX_WBITS | 16).decode("UTF-8")
+    assert decompress == expected_value
+    headers = result["multiValueHeaders"]
+    assert headers["Content-Encoding"] == ["gzip"]
+
+
 def test_compress():
     # GIVEN a function that has compress=True
     # AND an event with a "Accept-Encoding" that include gzip