diff --git a/src/cdk-experimental/popover-edit/constants.ts b/src/cdk-experimental/popover-edit/constants.ts
index 112f9ef9fc91..559e6cce66b7 100644
--- a/src/cdk-experimental/popover-edit/constants.ts
+++ b/src/cdk-experimental/popover-edit/constants.ts
@@ -23,3 +23,6 @@ export const EDIT_PANE_CLASS = 'cdk-edit-pane';
 
 /** Selector for finding the edit lens pane. */
 export const EDIT_PANE_SELECTOR = `.${EDIT_PANE_CLASS}, .mat-edit-pane`;
+
+/** Selector for table rows that should be skipped when moving focus. */
+export const SKIP_ROW_FOCUS_SELECTOR = '.cdk-popover-edit-skip-focus, .mat-popover-edit-skip-focus';
diff --git a/src/cdk-experimental/popover-edit/focus-dispatcher.ts b/src/cdk-experimental/popover-edit/focus-dispatcher.ts
index 0bd56469364d..da296af54343 100644
--- a/src/cdk-experimental/popover-edit/focus-dispatcher.ts
+++ b/src/cdk-experimental/popover-edit/focus-dispatcher.ts
@@ -11,7 +11,12 @@ import {LEFT_ARROW, UP_ARROW, RIGHT_ARROW, DOWN_ARROW} from '@angular/cdk/keycod
 import {Injectable, inject} from '@angular/core';
 import {PartialObserver} from 'rxjs';
 
-import {EDITABLE_CELL_SELECTOR, ROW_SELECTOR, TABLE_SELECTOR} from './constants';
+import {
+  EDITABLE_CELL_SELECTOR,
+  ROW_SELECTOR,
+  SKIP_ROW_FOCUS_SELECTOR,
+  TABLE_SELECTOR,
+} from './constants';
 import {closest} from './polyfill';
 
 /**
@@ -53,7 +58,11 @@ export class FocusDispatcher {
     const currentIndexWithinRow = Array.from(
       currentRow.querySelectorAll(EDITABLE_CELL_SELECTOR),
     ).indexOf(currentCell);
-    const newRowIndex = currentRowIndex + offset;
+
+    let newRowIndex = currentRowIndex + offset;
+    while (rows[newRowIndex]?.matches(SKIP_ROW_FOCUS_SELECTOR)) {
+      newRowIndex = newRowIndex + (offset > 0 ? 1 : -1);
+    }
 
     if (rows[newRowIndex]) {
       const rowToFocus = Array.from(
diff --git a/src/cdk-experimental/popover-edit/popover-edit.spec.ts b/src/cdk-experimental/popover-edit/popover-edit.spec.ts
index 6ad6476cdde2..c08a22b7c6fa 100644
--- a/src/cdk-experimental/popover-edit/popover-edit.spec.ts
+++ b/src/cdk-experimental/popover-edit/popover-edit.spec.ts
@@ -1044,6 +1044,103 @@ cdkPopoverEditTabOut`, fakeAsync(() => {
   }
 });
 
+@Component({
+  template: `
+  <div #table [dir]="direction">
+    <table cdk-table editable [dataSource]="dataSource" [multiTemplateDataRows]="true">
+      <ng-container cdkColumnDef="before">
+        <td cdk-cell *cdkCellDef="let element">
+          just a cell
+        </td>
+      </ng-container>
+
+      <ng-container cdkColumnDef="name">
+        <td cdk-cell *cdkCellDef="let element"
+            ${POPOVER_EDIT_DIRECTIVE_NAME}>
+          ${CELL_TEMPLATE}
+
+          <ng-template #nameEdit>
+            ${NAME_EDIT_TEMPLATE}
+          </ng-template>
+
+          <span *cdkIfRowHovered>
+            <button cdkEditOpen>Edit</button>
+          </span>
+        </td>
+      </ng-container>
+
+      <ng-container cdkColumnDef="weight">
+        <td cdk-cell *cdkCellDef="let element"
+            ${POPOVER_EDIT_DIRECTIVE_WEIGHT}>
+          {{element.weight}}
+
+          <ng-template #weightEdit>
+            ${WEIGHT_EDIT_TEMPLATE}
+          </ng-template>
+        </td>
+      </ng-container>
+
+      <ng-container cdkColumnDef="skip">
+        <td cdk-cell *cdkCellDef="let element" colspan="3"></td>
+      </ng-container>
+
+      <tr cdk-row *cdkRowDef="let row; columns: displayedColumns;"></tr>
+      <tr cdk-row *cdkRowDef="let row; columns: ['skip'];"
+          class="cdk-popover-edit-skip-focus"></tr>
+    </table>
+  <div>
+  `,
+  standalone: false,
+})
+class CdkTableWithSkipRows extends BaseTestComponent {
+  displayedColumns = ['before', 'name', 'weight'];
+  dataSource: ElementDataSource;
+
+  renderData() {
+    this.dataSource = new ElementDataSource();
+    this.cdr.markForCheck();
+  }
+}
+
+describe('CDK Popover Edit - with focus ignore rows', () => {
+  let component: CdkTableWithSkipRows;
+  let fixture: ComponentFixture<CdkTableWithSkipRows>;
+
+  const dispatchKey = (cell: HTMLElement, keyCode: number) =>
+    dispatchKeyboardEvent(cell, 'keydown', keyCode);
+
+  beforeEach(fakeAsync(() => {
+    TestBed.configureTestingModule({
+      imports: [CdkTableModule, CdkPopoverEditModule, FormsModule, BidiModule],
+      declarations: [CdkTableWithSkipRows],
+    });
+    fixture = TestBed.createComponent(CdkTableWithSkipRows);
+    component = fixture.componentInstance;
+    component.renderData();
+    fixture.detectChanges();
+    tick(10);
+    fixture.detectChanges();
+  }));
+
+  it('skips ignored rows when moving focus up', () => {
+    const rows = component.getRows();
+
+    getCells(rows[4])[1].focus();
+
+    dispatchKey(getCells(rows[4])[1], UP_ARROW);
+    expect(document.activeElement).toBe(getCells(rows[2])[1]);
+  });
+
+  it('skips ignored rows when moving focus down', () => {
+    const rows = component.getRows();
+
+    getCells(rows[0])[1].focus();
+
+    dispatchKey(getCells(rows[0])[1], DOWN_ARROW);
+    expect(document.activeElement).toBe(getCells(rows[2])[1]);
+  });
+});
+
 interface ChemicalElement {
   name: string;
   weight: number;