diff --git a/adafruit_platformdetect/board.py b/adafruit_platformdetect/board.py
index 3057ca8d..ea98f2dd 100644
--- a/adafruit_platformdetect/board.py
+++ b/adafruit_platformdetect/board.py
@@ -129,6 +129,8 @@ def id(self) -> Optional[str]:
             board_id = self._beaglebone_id()
         elif chip_id == chips.MCP2221:
             board_id = boards.MICROCHIP_MCP2221
+        elif chip_id == chips.USB_ISS:
+            board_id = boards.MICROCHIP_USB_ISS
         elif chip_id == chips.BINHO:
             board_id = boards.BINHO_NOVA
         elif chip_id == chips.LPC4330:
@@ -1056,6 +1058,7 @@ def lazily_generate_conditions():
             yield self.board.QTPY_U2IF
             yield self.board.QT2040_TRINKEY_U2IF
             yield self.board.KB2040_U2IF
+            yield self.board.MICROCHIP_USB_ISS
             yield self.board.OS_AGNOSTIC_BOARD
 
         return any(condition for condition in lazily_generate_conditions())
@@ -1126,6 +1129,11 @@ def microchip_mcp2221(self) -> bool:
         """Check whether the current board is a Microchip MCP2221."""
         return self.id == boards.MICROCHIP_MCP2221
 
+    @property
+    def microchip_usb_iss(self) -> bool:
+        """Check whether the current board is a Microchip USB_ISS."""
+        return self.id == boards.MICROCHIP_USB_ISS
+
     @property
     def os_agnostic_board(self) -> bool:
         """Check whether the current board is an OS agnostic special case."""
diff --git a/adafruit_platformdetect/chip.py b/adafruit_platformdetect/chip.py
index 99588235..93bc3730 100644
--- a/adafruit_platformdetect/chip.py
+++ b/adafruit_platformdetect/chip.py
@@ -98,9 +98,13 @@ def id(
                     "BLINKA_MCP2221 environment variable "
                     + "set, but no MCP2221 device found"
                 )
+            if os.environ.get("BLINKA_USB_ISS"):
+                self._chip_id = chips.USB_ISS
+
             if os.environ.get("BLINKA_OS_AGNOSTIC"):
                 # we don't need to look for this chip, it's just a flag
                 self._chip_id = chips.OS_AGNOSTIC
+
                 return self._chip_id
             if os.environ.get("BLINKA_U2IF"):
                 import hid
diff --git a/adafruit_platformdetect/constants/boards.py b/adafruit_platformdetect/constants/boards.py
index b60de084..41a72f90 100644
--- a/adafruit_platformdetect/constants/boards.py
+++ b/adafruit_platformdetect/constants/boards.py
@@ -165,6 +165,7 @@
 LICHEEPI_4A = "LICHEEPI_4A"
 
 MICROCHIP_MCP2221 = "MICROCHIP_MCP2221"
+MICROCHIP_USB_ISS = "MICROCHIP_USB_ISS"
 
 # Linkspirte Pcduino based boards
 PCDUINO2 = "PCDUINO2"
diff --git a/adafruit_platformdetect/constants/chips.py b/adafruit_platformdetect/constants/chips.py
index fee42603..853014d0 100644
--- a/adafruit_platformdetect/constants/chips.py
+++ b/adafruit_platformdetect/constants/chips.py
@@ -77,6 +77,7 @@
 RP2040_U2IF = "RP2040_U2IF"
 D1_RISCV = "D1_RISCV"
 ATOM_J4105 = "ATOM_J4105"
+USB_ISS = "USB_ISS"
 TH1520 = "TH1520"
 
 BCM_RANGE = {"BCM2708", "BCM2709", "BCM2711", "BCM2712", "BCM2835", "BCM2837"}