diff --git a/src/CommunityToolkit.Mvvm.SourceGenerators/ComponentModel/Models/PropertyInfo.cs b/src/CommunityToolkit.Mvvm.SourceGenerators/ComponentModel/Models/PropertyInfo.cs
index 2bf62d0de..8c3bca4da 100644
--- a/src/CommunityToolkit.Mvvm.SourceGenerators/ComponentModel/Models/PropertyInfo.cs
+++ b/src/CommunityToolkit.Mvvm.SourceGenerators/ComponentModel/Models/PropertyInfo.cs
@@ -20,6 +20,7 @@ namespace CommunityToolkit.Mvvm.SourceGenerators.ComponentModel.Models;
 /// <param name="IsOldPropertyValueDirectlyReferenced">Whether the old property value is being directly referenced.</param>
 /// <param name="IsReferenceTypeOrUnconstraindTypeParameter">Indicates whether the property is of a reference type or an unconstrained type parameter.</param>
 /// <param name="IncludeMemberNotNullOnSetAccessor">Indicates whether to include nullability annotations on the setter.</param>
+/// <param name="IncludeRequiresUnreferencedCodeOnSetAccessor">Indicates whether to annotate the setter as requiring unreferenced code.</param>
 /// <param name="ForwardedAttributes">The sequence of forwarded attributes for the generated property.</param>
 internal sealed record PropertyInfo(
     string TypeNameWithNullabilityAnnotations,
@@ -33,4 +34,5 @@ internal sealed record PropertyInfo(
     bool IsOldPropertyValueDirectlyReferenced,
     bool IsReferenceTypeOrUnconstraindTypeParameter,
     bool IncludeMemberNotNullOnSetAccessor,
+    bool IncludeRequiresUnreferencedCodeOnSetAccessor,
     EquatableArray<AttributeInfo> ForwardedAttributes);
diff --git a/src/CommunityToolkit.Mvvm.SourceGenerators/ComponentModel/ObservablePropertyGenerator.Execute.cs b/src/CommunityToolkit.Mvvm.SourceGenerators/ComponentModel/ObservablePropertyGenerator.Execute.cs
index 6aefd581a..d029295bd 100644
--- a/src/CommunityToolkit.Mvvm.SourceGenerators/ComponentModel/ObservablePropertyGenerator.Execute.cs
+++ b/src/CommunityToolkit.Mvvm.SourceGenerators/ComponentModel/ObservablePropertyGenerator.Execute.cs
@@ -297,6 +297,13 @@ public static bool TryGetInfo(
 
             token.ThrowIfCancellationRequested();
 
+            // We should generate [RequiresUnreferencedCode] on the setter if [NotifyDataErrorInfo] was used and the attribute is available
+            bool includeRequiresUnreferencedCodeOnSetAccessor =
+                notifyDataErrorInfo &&
+                semanticModel.Compilation.HasAccessibleTypeWithMetadataName("System.Diagnostics.CodeAnalysis.RequiresUnreferencedCodeAttribute");
+
+            token.ThrowIfCancellationRequested();
+
             // Prepare the effective property changing/changed names. For the property changing names,
             // there are two possible cases: if the mode is disabled, then there are no names to report
             // at all. If the mode is enabled, then the list is just the same as for property changed.
@@ -321,6 +328,7 @@ public static bool TryGetInfo(
                 isOldPropertyValueDirectlyReferenced,
                 isReferenceTypeOrUnconstraindTypeParameter,
                 includeMemberNotNullOnSetAccessor,
+                includeRequiresUnreferencedCodeOnSetAccessor,
                 forwardedAttributes.ToImmutable());
 
             diagnostics = builder.ToImmutable();
@@ -1044,6 +1052,19 @@ public static MemberDeclarationSyntax GetPropertySyntax(PropertyInfo propertyInf
                             AttributeArgument(LiteralExpression(SyntaxKind.StringLiteralExpression, Literal(propertyInfo.FieldName)))))));
             }
 
+            // Add the [RequiresUnreferencedCode] attribute if needed:
+            //
+            // [RequiresUnreferencedCode("The type of the current instance cannot be statically discovered.")]
+            // <SET_ACCESSOR>
+            if (propertyInfo.IncludeRequiresUnreferencedCodeOnSetAccessor)
+            {
+                setAccessor = setAccessor.AddAttributeLists(
+                    AttributeList(SingletonSeparatedList(
+                        Attribute(IdentifierName("global::System.Diagnostics.CodeAnalysis.RequiresUnreferencedCode"))
+                        .AddArgumentListArguments(
+                            AttributeArgument(LiteralExpression(SyntaxKind.StringLiteralExpression, Literal("The type of the current instance cannot be statically discovered.")))))));
+            }
+
             // Construct the generated property as follows:
             //
             // /// <inheritdoc cref="<FIELD_NAME>"/>
diff --git a/tests/CommunityToolkit.Mvvm.SourceGenerators.UnitTests/Test_SourceGeneratorsCodegen.cs b/tests/CommunityToolkit.Mvvm.SourceGenerators.UnitTests/Test_SourceGeneratorsCodegen.cs
index f98b7e917..c3e48fba6 100644
--- a/tests/CommunityToolkit.Mvvm.SourceGenerators.UnitTests/Test_SourceGeneratorsCodegen.cs
+++ b/tests/CommunityToolkit.Mvvm.SourceGenerators.UnitTests/Test_SourceGeneratorsCodegen.cs
@@ -2733,6 +2733,291 @@ internal static class __KnownINotifyPropertyChangedArgs
         VerifyGenerateSources(source, new[] { new ObservablePropertyGenerator() }, ("MyApp.MyViewModel.g.cs", result), ("__KnownINotifyPropertyChangingArgs.g.cs", null), ("__KnownINotifyPropertyChangedArgs.g.cs", changedArgs));
     }
 
+    [TestMethod]
+    public void ObservableProperty_NotifyDataErrorInfo_EmitsTrimAnnotationsWhenNeeded()
+    {
+        string source = """
+            using System.ComponentModel.DataAnnotations;
+            using CommunityToolkit.Mvvm.ComponentModel;
+
+            #nullable enable
+
+            namespace MyApp;
+            
+            partial class MyViewModel : ObservableValidator
+            {
+                [ObservableProperty]
+                [NotifyDataErrorInfo]
+                [Required]
+                private string? name;
+            }
+            """;
+
+#if NET6_0_OR_GREATER
+        string result = """
+            // <auto-generated/>
+            #pragma warning disable
+            #nullable enable
+            namespace MyApp
+            {
+                /// <inheritdoc/>
+                partial class MyViewModel
+                {
+                    /// <inheritdoc cref="name"/>
+                    [global::System.CodeDom.Compiler.GeneratedCode("CommunityToolkit.Mvvm.SourceGenerators.ObservablePropertyGenerator", <ASSEMBLY_VERSION>)]
+                    [global::System.Diagnostics.CodeAnalysis.ExcludeFromCodeCoverage]
+                    [global::System.ComponentModel.DataAnnotations.RequiredAttribute()]
+                    public string? Name
+                    {
+                        get => name;
+                        [global::System.Diagnostics.CodeAnalysis.RequiresUnreferencedCode("The type of the current instance cannot be statically discovered.")]
+                        set
+                        {
+                            if (!global::System.Collections.Generic.EqualityComparer<string?>.Default.Equals(name, value))
+                            {
+                                OnNameChanging(value);
+                                OnNameChanging(default, value);
+                                OnPropertyChanging(global::CommunityToolkit.Mvvm.ComponentModel.__Internals.__KnownINotifyPropertyChangingArgs.Name);
+                                name = value;
+                                ValidateProperty(value, "Name");
+                                OnNameChanged(value);
+                                OnNameChanged(default, value);
+                                OnPropertyChanged(global::CommunityToolkit.Mvvm.ComponentModel.__Internals.__KnownINotifyPropertyChangedArgs.Name);
+                            }
+                        }
+                    }
+
+                    /// <summary>Executes the logic for when <see cref="Name"/> is changing.</summary>
+                    /// <param name="value">The new property value being set.</param>
+                    /// <remarks>This method is invoked right before the value of <see cref="Name"/> is changed.</remarks>
+                    [global::System.CodeDom.Compiler.GeneratedCode("CommunityToolkit.Mvvm.SourceGenerators.ObservablePropertyGenerator", <ASSEMBLY_VERSION>)]
+                    partial void OnNameChanging(string? value);
+                    /// <summary>Executes the logic for when <see cref="Name"/> is changing.</summary>
+                    /// <param name="oldValue">The previous property value that is being replaced.</param>
+                    /// <param name="newValue">The new property value being set.</param>
+                    /// <remarks>This method is invoked right before the value of <see cref="Name"/> is changed.</remarks>
+                    [global::System.CodeDom.Compiler.GeneratedCode("CommunityToolkit.Mvvm.SourceGenerators.ObservablePropertyGenerator", <ASSEMBLY_VERSION>)]
+                    partial void OnNameChanging(string? oldValue, string? newValue);
+                    /// <summary>Executes the logic for when <see cref="Name"/> just changed.</summary>
+                    /// <param name="value">The new property value that was set.</param>
+                    /// <remarks>This method is invoked right after the value of <see cref="Name"/> is changed.</remarks>
+                    [global::System.CodeDom.Compiler.GeneratedCode("CommunityToolkit.Mvvm.SourceGenerators.ObservablePropertyGenerator", <ASSEMBLY_VERSION>)]
+                    partial void OnNameChanged(string? value);
+                    /// <summary>Executes the logic for when <see cref="Name"/> just changed.</summary>
+                    /// <param name="oldValue">The previous property value that was replaced.</param>
+                    /// <param name="newValue">The new property value that was set.</param>
+                    /// <remarks>This method is invoked right after the value of <see cref="Name"/> is changed.</remarks>
+                    [global::System.CodeDom.Compiler.GeneratedCode("CommunityToolkit.Mvvm.SourceGenerators.ObservablePropertyGenerator", <ASSEMBLY_VERSION>)]
+                    partial void OnNameChanged(string? oldValue, string? newValue);
+                }
+            }
+            """;
+#else
+        string result = """
+            // <auto-generated/>
+            #pragma warning disable
+            #nullable enable
+            namespace MyApp
+            {
+                /// <inheritdoc/>
+                partial class MyViewModel
+                {
+                    /// <inheritdoc cref="name"/>
+                    [global::System.CodeDom.Compiler.GeneratedCode("CommunityToolkit.Mvvm.SourceGenerators.ObservablePropertyGenerator", <ASSEMBLY_VERSION>)]
+                    [global::System.Diagnostics.CodeAnalysis.ExcludeFromCodeCoverage]
+                    [global::System.ComponentModel.DataAnnotations.RequiredAttribute()]
+                    public string? Name
+                    {
+                        get => name;
+                        set
+                        {
+                            if (!global::System.Collections.Generic.EqualityComparer<string?>.Default.Equals(name, value))
+                            {
+                                OnNameChanging(value);
+                                OnNameChanging(default, value);
+                                OnPropertyChanging(global::CommunityToolkit.Mvvm.ComponentModel.__Internals.__KnownINotifyPropertyChangingArgs.Name);
+                                name = value;
+                                ValidateProperty(value, "Name");
+                                OnNameChanged(value);
+                                OnNameChanged(default, value);
+                                OnPropertyChanged(global::CommunityToolkit.Mvvm.ComponentModel.__Internals.__KnownINotifyPropertyChangedArgs.Name);
+                            }
+                        }
+                    }
+
+                    /// <summary>Executes the logic for when <see cref="Name"/> is changing.</summary>
+                    /// <param name="value">The new property value being set.</param>
+                    /// <remarks>This method is invoked right before the value of <see cref="Name"/> is changed.</remarks>
+                    [global::System.CodeDom.Compiler.GeneratedCode("CommunityToolkit.Mvvm.SourceGenerators.ObservablePropertyGenerator", <ASSEMBLY_VERSION>)]
+                    partial void OnNameChanging(string? value);
+                    /// <summary>Executes the logic for when <see cref="Name"/> is changing.</summary>
+                    /// <param name="oldValue">The previous property value that is being replaced.</param>
+                    /// <param name="newValue">The new property value being set.</param>
+                    /// <remarks>This method is invoked right before the value of <see cref="Name"/> is changed.</remarks>
+                    [global::System.CodeDom.Compiler.GeneratedCode("CommunityToolkit.Mvvm.SourceGenerators.ObservablePropertyGenerator", <ASSEMBLY_VERSION>)]
+                    partial void OnNameChanging(string? oldValue, string? newValue);
+                    /// <summary>Executes the logic for when <see cref="Name"/> just changed.</summary>
+                    /// <param name="value">The new property value that was set.</param>
+                    /// <remarks>This method is invoked right after the value of <see cref="Name"/> is changed.</remarks>
+                    [global::System.CodeDom.Compiler.GeneratedCode("CommunityToolkit.Mvvm.SourceGenerators.ObservablePropertyGenerator", <ASSEMBLY_VERSION>)]
+                    partial void OnNameChanged(string? value);
+                    /// <summary>Executes the logic for when <see cref="Name"/> just changed.</summary>
+                    /// <param name="oldValue">The previous property value that was replaced.</param>
+                    /// <param name="newValue">The new property value that was set.</param>
+                    /// <remarks>This method is invoked right after the value of <see cref="Name"/> is changed.</remarks>
+                    [global::System.CodeDom.Compiler.GeneratedCode("CommunityToolkit.Mvvm.SourceGenerators.ObservablePropertyGenerator", <ASSEMBLY_VERSION>)]
+                    partial void OnNameChanged(string? oldValue, string? newValue);
+                }
+            }
+            """;
+#endif
+
+        VerifyGenerateSources(source, new[] { new ObservablePropertyGenerator() }, ("MyApp.MyViewModel.g.cs", result));
+    }
+
+    [TestMethod]
+    public void ObservableProperty_NotifyDataErrorInfo_EmitsTrimAnnotationsWhenNeeded_AppendToNullableAttribute()
+    {
+        string source = """
+            using System.ComponentModel.DataAnnotations;
+            using CommunityToolkit.Mvvm.ComponentModel;
+
+            #nullable enable
+
+            namespace MyApp;
+            
+            partial class MyViewModel : ObservableValidator
+            {
+                [ObservableProperty]
+                [NotifyDataErrorInfo]
+                [Required]
+                private string name;
+            }
+            """;
+
+#if NET6_0_OR_GREATER
+        string result = """
+            // <auto-generated/>
+            #pragma warning disable
+            #nullable enable
+            namespace MyApp
+            {
+                /// <inheritdoc/>
+                partial class MyViewModel
+                {
+                    /// <inheritdoc cref="name"/>
+                    [global::System.CodeDom.Compiler.GeneratedCode("CommunityToolkit.Mvvm.SourceGenerators.ObservablePropertyGenerator", <ASSEMBLY_VERSION>)]
+                    [global::System.Diagnostics.CodeAnalysis.ExcludeFromCodeCoverage]
+                    [global::System.ComponentModel.DataAnnotations.RequiredAttribute()]
+                    public string Name
+                    {
+                        get => name;
+                        [global::System.Diagnostics.CodeAnalysis.MemberNotNull("name")]
+                        [global::System.Diagnostics.CodeAnalysis.RequiresUnreferencedCode("The type of the current instance cannot be statically discovered.")]
+                        set
+                        {
+                            if (!global::System.Collections.Generic.EqualityComparer<string>.Default.Equals(name, value))
+                            {
+                                OnNameChanging(value);
+                                OnNameChanging(default, value);
+                                OnPropertyChanging(global::CommunityToolkit.Mvvm.ComponentModel.__Internals.__KnownINotifyPropertyChangingArgs.Name);
+                                name = value;
+                                ValidateProperty(value, "Name");
+                                OnNameChanged(value);
+                                OnNameChanged(default, value);
+                                OnPropertyChanged(global::CommunityToolkit.Mvvm.ComponentModel.__Internals.__KnownINotifyPropertyChangedArgs.Name);
+                            }
+                        }
+                    }
+
+                    /// <summary>Executes the logic for when <see cref="Name"/> is changing.</summary>
+                    /// <param name="value">The new property value being set.</param>
+                    /// <remarks>This method is invoked right before the value of <see cref="Name"/> is changed.</remarks>
+                    [global::System.CodeDom.Compiler.GeneratedCode("CommunityToolkit.Mvvm.SourceGenerators.ObservablePropertyGenerator", <ASSEMBLY_VERSION>)]
+                    partial void OnNameChanging(string value);
+                    /// <summary>Executes the logic for when <see cref="Name"/> is changing.</summary>
+                    /// <param name="oldValue">The previous property value that is being replaced.</param>
+                    /// <param name="newValue">The new property value being set.</param>
+                    /// <remarks>This method is invoked right before the value of <see cref="Name"/> is changed.</remarks>
+                    [global::System.CodeDom.Compiler.GeneratedCode("CommunityToolkit.Mvvm.SourceGenerators.ObservablePropertyGenerator", <ASSEMBLY_VERSION>)]
+                    partial void OnNameChanging(string? oldValue, string newValue);
+                    /// <summary>Executes the logic for when <see cref="Name"/> just changed.</summary>
+                    /// <param name="value">The new property value that was set.</param>
+                    /// <remarks>This method is invoked right after the value of <see cref="Name"/> is changed.</remarks>
+                    [global::System.CodeDom.Compiler.GeneratedCode("CommunityToolkit.Mvvm.SourceGenerators.ObservablePropertyGenerator", <ASSEMBLY_VERSION>)]
+                    partial void OnNameChanged(string value);
+                    /// <summary>Executes the logic for when <see cref="Name"/> just changed.</summary>
+                    /// <param name="oldValue">The previous property value that was replaced.</param>
+                    /// <param name="newValue">The new property value that was set.</param>
+                    /// <remarks>This method is invoked right after the value of <see cref="Name"/> is changed.</remarks>
+                    [global::System.CodeDom.Compiler.GeneratedCode("CommunityToolkit.Mvvm.SourceGenerators.ObservablePropertyGenerator", <ASSEMBLY_VERSION>)]
+                    partial void OnNameChanged(string? oldValue, string newValue);
+                }
+            }
+            """;
+#else
+        string result = """
+            // <auto-generated/>
+            #pragma warning disable
+            #nullable enable
+            namespace MyApp
+            {
+                /// <inheritdoc/>
+                partial class MyViewModel
+                {
+                    /// <inheritdoc cref="name"/>
+                    [global::System.CodeDom.Compiler.GeneratedCode("CommunityToolkit.Mvvm.SourceGenerators.ObservablePropertyGenerator", <ASSEMBLY_VERSION>)]
+                    [global::System.Diagnostics.CodeAnalysis.ExcludeFromCodeCoverage]
+                    [global::System.ComponentModel.DataAnnotations.RequiredAttribute()]
+                    public string Name
+                    {
+                        get => name;
+                        set
+                        {
+                            if (!global::System.Collections.Generic.EqualityComparer<string>.Default.Equals(name, value))
+                            {
+                                OnNameChanging(value);
+                                OnNameChanging(default, value);
+                                OnPropertyChanging(global::CommunityToolkit.Mvvm.ComponentModel.__Internals.__KnownINotifyPropertyChangingArgs.Name);
+                                name = value;
+                                ValidateProperty(value, "Name");
+                                OnNameChanged(value);
+                                OnNameChanged(default, value);
+                                OnPropertyChanged(global::CommunityToolkit.Mvvm.ComponentModel.__Internals.__KnownINotifyPropertyChangedArgs.Name);
+                            }
+                        }
+                    }
+
+                    /// <summary>Executes the logic for when <see cref="Name"/> is changing.</summary>
+                    /// <param name="value">The new property value being set.</param>
+                    /// <remarks>This method is invoked right before the value of <see cref="Name"/> is changed.</remarks>
+                    [global::System.CodeDom.Compiler.GeneratedCode("CommunityToolkit.Mvvm.SourceGenerators.ObservablePropertyGenerator", <ASSEMBLY_VERSION>)]
+                    partial void OnNameChanging(string value);
+                    /// <summary>Executes the logic for when <see cref="Name"/> is changing.</summary>
+                    /// <param name="oldValue">The previous property value that is being replaced.</param>
+                    /// <param name="newValue">The new property value being set.</param>
+                    /// <remarks>This method is invoked right before the value of <see cref="Name"/> is changed.</remarks>
+                    [global::System.CodeDom.Compiler.GeneratedCode("CommunityToolkit.Mvvm.SourceGenerators.ObservablePropertyGenerator", <ASSEMBLY_VERSION>)]
+                    partial void OnNameChanging(string? oldValue, string newValue);
+                    /// <summary>Executes the logic for when <see cref="Name"/> just changed.</summary>
+                    /// <param name="value">The new property value that was set.</param>
+                    /// <remarks>This method is invoked right after the value of <see cref="Name"/> is changed.</remarks>
+                    [global::System.CodeDom.Compiler.GeneratedCode("CommunityToolkit.Mvvm.SourceGenerators.ObservablePropertyGenerator", <ASSEMBLY_VERSION>)]
+                    partial void OnNameChanged(string value);
+                    /// <summary>Executes the logic for when <see cref="Name"/> just changed.</summary>
+                    /// <param name="oldValue">The previous property value that was replaced.</param>
+                    /// <param name="newValue">The new property value that was set.</param>
+                    /// <remarks>This method is invoked right after the value of <see cref="Name"/> is changed.</remarks>
+                    [global::System.CodeDom.Compiler.GeneratedCode("CommunityToolkit.Mvvm.SourceGenerators.ObservablePropertyGenerator", <ASSEMBLY_VERSION>)]
+                    partial void OnNameChanged(string? oldValue, string newValue);
+                }
+            }
+            """;
+#endif
+
+        VerifyGenerateSources(source, new[] { new ObservablePropertyGenerator() }, ("MyApp.MyViewModel.g.cs", result));
+    }
+
     /// <summary>
     /// Generates the requested sources
     /// </summary>